STRINGSTRING
pola-1 pola-1 rpl-2 rpl-2 ntl-2 ntl-2 atf-7 atf-7 hsp-70 hsp-70 elt-2 elt-2 pal-1 pal-1 nhr-46 nhr-46 numr-2 numr-2 numr-1 numr-1 rrf-3 rrf-3 unc-54 unc-54 F15E6.3 F15E6.3 gst-38 gst-38 gcs-1 gcs-1 xrep-4 xrep-4 gpdh-1 gpdh-1 sun-1 sun-1 let-711 let-711 F57B9.3 F57B9.3 sta-2 sta-2 elt-3 elt-3 rde-1 rde-1 nhr-49 nhr-49 unc-119 unc-119 cdc-42 cdc-42 daf-16 daf-16 rol-6 rol-6 cyp-13A8 cyp-13A8 cyp-34A1 cyp-34A1 skn-1 skn-1 act-5 act-5 hlh-30 hlh-30 Y37B11A.2 Y37B11A.2 arx-5 arx-5 hsf-1 hsf-1 daf-2 daf-2 ntl-3 ntl-3 ccf-1 ccf-1 arx-3 arx-3 ccr-4 ccr-4 hizr-1 hizr-1 gst-30 gst-30
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pola-1DNA polymerase. (1456 aa)
rpl-260S ribosomal protein L8. (260 aa)
ntl-2NOT2_3_5 domain-containing protein. (444 aa)
atf-7BZIP domain-containing protein. (509 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
elt-2Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...] (433 aa)
pal-1Homeobox protein pal-1; Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. [...] (270 aa)
nhr-46Nuclear Hormone Receptor family. (576 aa)
numr-2NUclear localized Metal Responsive. (281 aa)
numr-1NUclear localized Metal Responsive. (281 aa)
rrf-3RNA-dependent RNA polymerase Family. (1765 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
F15E6.3RRM-type RNA binding protein. (118 aa)
gst-38Glutathione S-Transferase. (209 aa)
gcs-1Glutamate--cysteine ligase; Plays a role in resistance to arsenite. May play a role in the oxidative stress response induced by reactive oxygen species produced during infection by pathogenic bacteria. Together with trxr-1, required for the reduction of disulfide groups in the cuticle during molting. (654 aa)
xrep-4F-box domain-containing protein. (361 aa)
gpdh-1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (374 aa)
sun-1Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. (473 aa)
let-711Not1 domain-containing protein. (2641 aa)
F57B9.3Uncharacterized protein; Belongs to the DEAD box helicase family. (394 aa)
sta-2Signal transducer and activator of transcription b; Carries out a dual function: signal transduction and activation of transcription (By similarity). By regulating the up- regulation in the epidermis of antimicrobial peptides nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment. Belongs to the transcription factor STAT family. (567 aa)
elt-3GATA-type domain-containing protein. (317 aa)
rde-1RNA interference promoting factor RDE-1. (1020 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
cyp-13A8Putative cytochrome P450 CYP13A8; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (509 aa)
cyp-34A1CYtochrome P450 family; Belongs to the cytochrome P450 family. (504 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
act-5ACTin. (375 aa)
hlh-30BHLH domain-containing protein. (524 aa)
Y37B11A.2DNA polymerase. (1303 aa)
arx-5Probable actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
hsf-1HSF_DOMAIN domain-containing protein. (671 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
ntl-3NOT2_3_5 domain-containing protein. (701 aa)
ccf-1CCR4-NOT transcription complex subunit 7; Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression; Belongs to the CAF1 family. (310 aa)
arx-3Actin-related protein 2/3 complex subunit. (375 aa)
ccr-4Endo/exonuclease/phosphatase domain-containing protein. (677 aa)
hizr-1High zinc activated nuclear receptor protein; Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated. (413 aa)
gst-30Glutathione S-Transferase. (213 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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