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cpr-6 cpr-6 daf-2 daf-2 cpr-5 cpr-5 W07B8.4 W07B8.4 cpr-8 cpr-8 cpr-3 cpr-3 tra-3 tra-3 F57F5.1 F57F5.1 cpr-4 cpr-4 sph-1 sph-1 cpr-2 cpr-2 F32H5.1 F32H5.1 cpr-1 cpr-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cpr-6Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family. (379 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
cpr-5Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family. (344 aa)
W07B8.4Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
cpr-8Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
cpr-3Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa)
tra-3Calpain-5; Required for the correct female sexual development of the soma and germline in hermaphrodite animals, while being fully dispensable in males. Has calcium-dependent proteolytic activity and is involved in the cleavage of tra-2, for which it acts as a potentiator. Capable of calcium-dependent autolysis. Part of the necrosis cell death pathway. Required for necrosis of intestinal cells induced by B.thuringiensis endotoxin Cry6Aa ; Belongs to the peptidase C2 family. (648 aa)
F57F5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (351 aa)
cpr-4Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa)
sph-1MARVEL domain-containing protein. (227 aa)
cpr-2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa)
F32H5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (356 aa)
cpr-1Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family. (329 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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