node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act-5 | cav-1 | T25C8.2.2 | T13F2.8a.1 | ACTin. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. | 0.860 |
act-5 | gpd-2 | T25C8.2.2 | K10B3.8.2 | ACTin. | Glyceraldehyde-3-phosphate dehydrogenase 2. | 0.902 |
act-5 | tsg-101 | T25C8.2.2 | C09G12.9.1 | ACTin. | Tumor Susceptibility Gene homolog. | 0.735 |
act-5 | ubc-9 | T25C8.2.2 | F29B9.6.2 | ACTin. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. | 0.403 |
act-5 | vps-24 | T25C8.2.2 | T27F7.1.2 | ACTin. | Related to yeast Vacuolar Protein Sorting factor. | 0.579 |
cav-1 | act-5 | T13F2.8a.1 | T25C8.2.2 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. | ACTin. | 0.860 |
cav-1 | tsg-101 | T13F2.8a.1 | C09G12.9.1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. | Tumor Susceptibility Gene homolog. | 0.419 |
gpd-2 | act-5 | K10B3.8.2 | T25C8.2.2 | Glyceraldehyde-3-phosphate dehydrogenase 2. | ACTin. | 0.902 |
stam-1 | tsg-101 | C34G6.7a.1 | C09G12.9.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Tumor Susceptibility Gene homolog. | 0.991 |
stam-1 | vps-20 | C34G6.7a.1 | Y65B4A.3.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Related to yeast Vacuolar Protein Sorting factor. | 0.924 |
stam-1 | vps-24 | C34G6.7a.1 | T27F7.1.2 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Related to yeast Vacuolar Protein Sorting factor. | 0.927 |
stam-1 | vps-25 | C34G6.7a.1 | W02A11.2.2 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Related to yeast Vacuolar Protein Sorting factor. | 0.914 |
stam-1 | vps-28 | C34G6.7a.1 | Y87G2A.10a.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. | 0.959 |
stam-1 | vps-36 | C34G6.7a.1 | F17C11.8.2 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | GLUE N-terminal domain-containing protein. | 0.933 |
stam-1 | vps-4 | C34G6.7a.1 | Y34D9A.10.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Related to yeast Vacuolar Protein Sorting factor; Belongs to the AAA ATPase family. | 0.499 |
tsg-101 | act-5 | C09G12.9.1 | T25C8.2.2 | Tumor Susceptibility Gene homolog. | ACTin. | 0.735 |
tsg-101 | cav-1 | C09G12.9.1 | T13F2.8a.1 | Tumor Susceptibility Gene homolog. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. | 0.419 |
tsg-101 | stam-1 | C09G12.9.1 | C34G6.7a.1 | Tumor Susceptibility Gene homolog. | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | 0.991 |
tsg-101 | vps-20 | C09G12.9.1 | Y65B4A.3.1 | Tumor Susceptibility Gene homolog. | Related to yeast Vacuolar Protein Sorting factor. | 0.964 |
tsg-101 | vps-24 | C09G12.9.1 | T27F7.1.2 | Tumor Susceptibility Gene homolog. | Related to yeast Vacuolar Protein Sorting factor. | 0.980 |