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cht-1 cht-1 deb-1 deb-1 gdi-1 gdi-1 cht-4 cht-4 elt-1 elt-1 atn-1 atn-1 afd-1 afd-1 act-5 act-5 myo-2 myo-2 cht-2 cht-2 vab-7 vab-7 zyx-1 zyx-1 lim-9 lim-9 nmy-2 nmy-2 unc-97 unc-97 nhr-171 nhr-171 pxl-1 pxl-1 sax-7 sax-7 sdz-1 sdz-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cht-1Probable endochitinase. (617 aa)
deb-1Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa)
gdi-1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (459 aa)
cht-4Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (360 aa)
elt-1Transcription factor elt-1; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof. During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage. The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres. Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion. Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif. Probably represses ex [...] (488 aa)
atn-1AcTiniN. (920 aa)
afd-1PDZ domain-containing protein. (1660 aa)
act-5ACTin. (375 aa)
myo-2Myosin-2; Muscle contraction. (1947 aa)
cht-2CHiTinase; Belongs to the glycosyl hydrolase 18 family. (626 aa)
vab-7Homeobox protein vab-7; Required for posterior-specific pattern formation in the embryo and may have a role in regulating egl-5 expression. (247 aa)
zyx-1Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development. (647 aa)
lim-9LIM domain family. (793 aa)
nmy-2Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2003 aa)
unc-97LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons. (348 aa)
nhr-171Nuclear Hormone Receptor family. (386 aa)
pxl-1Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. (413 aa)
sax-7Fibronectin type-III domain-containing protein. (1331 aa)
sdz-1Skn-1 dependent zygotic transcript 1 protein; May have a role in mesendoderm development during embryogenesis. (239 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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