node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C46A5.4 | T06D8.10 | C46A5.4.1 | T06D8.10.1 | Uncharacterized protein. | Uncharacterized protein. | 0.699 |
C46A5.4 | pxn-1 | C46A5.4.1 | ZK994.3.1 | Uncharacterized protein. | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. | 0.705 |
C46A5.4 | pxn-2 | C46A5.4.1 | K09C8.5.1 | Uncharacterized protein. | PeroXidasiN (Drosophila peroxidase) homolog. | 0.709 |
T06D8.10 | C46A5.4 | T06D8.10.1 | C46A5.4.1 | Uncharacterized protein. | Uncharacterized protein. | 0.699 |
T06D8.10 | pxn-1 | T06D8.10.1 | ZK994.3.1 | Uncharacterized protein. | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. | 0.707 |
T06D8.10 | pxn-2 | T06D8.10.1 | K09C8.5.1 | Uncharacterized protein. | PeroXidasiN (Drosophila peroxidase) homolog. | 0.711 |
cdt-1 | ndc-80 | Y54E10A.15.1 | W01B6.9.1 | CDT1 domain-containing protein. | Kinetochore protein ndc-80; Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores. Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolym [...] | 0.769 |
cdt-1 | ska-1 | Y54E10A.15.1 | Y106G6H.15.2 | CDT1 domain-containing protein. | Spindle and kinetochore-associated protein 1; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of micr [...] | 0.466 |
cpn-3 | cpn-4 | F28H1.2.1 | F49D11.8.1 | Calponin-homology (CH) domain-containing protein. | Calponin-homology (CH) domain-containing protein. | 0.403 |
cpn-3 | ska-1 | F28H1.2.1 | Y106G6H.15.2 | Calponin-homology (CH) domain-containing protein. | Spindle and kinetochore-associated protein 1; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of micr [...] | 0.469 |
cpn-4 | cpn-3 | F49D11.8.1 | F28H1.2.1 | Calponin-homology (CH) domain-containing protein. | Calponin-homology (CH) domain-containing protein. | 0.403 |
cpn-4 | pxn-1 | F49D11.8.1 | ZK994.3.1 | Calponin-homology (CH) domain-containing protein. | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. | 0.518 |
cpn-4 | ska-1 | F49D11.8.1 | Y106G6H.15.2 | Calponin-homology (CH) domain-containing protein. | Spindle and kinetochore-associated protein 1; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of micr [...] | 0.481 |
his-41 | his-48 | C50F4.5.1 | B0035.8.1 | Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.402 |
his-48 | his-41 | B0035.8.1 | C50F4.5.1 | Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.402 |
ndc-80 | cdt-1 | W01B6.9.1 | Y54E10A.15.1 | Kinetochore protein ndc-80; Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores. Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolym [...] | CDT1 domain-containing protein. | 0.769 |
ndc-80 | ska-1 | W01B6.9.1 | Y106G6H.15.2 | Kinetochore protein ndc-80; Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores. Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolym [...] | Spindle and kinetochore-associated protein 1; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of micr [...] | 0.922 |
pxn-1 | C46A5.4 | ZK994.3.1 | C46A5.4.1 | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. | Uncharacterized protein. | 0.705 |
pxn-1 | T06D8.10 | ZK994.3.1 | T06D8.10.1 | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. | Uncharacterized protein. | 0.707 |
pxn-1 | cpn-4 | ZK994.3.1 | F49D11.8.1 | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. | Calponin-homology (CH) domain-containing protein. | 0.518 |