STRINGSTRING
lron-15 lron-15 sid-1 sid-1 C34E7.4 C34E7.4 meg-4 meg-4 sym-1 sym-1 ptr-4 ptr-4 ptr-5 ptr-5 ptr-6 ptr-6 drh-3 drh-3 prg-1 prg-1 glp-1 glp-1 daf-12 daf-12 unc-54 unc-54 F11E6.9 F11E6.9 col-165 col-165 prde-1 prde-1 cut-3 cut-3 ekl-1 ekl-1 daf-6 daf-6 hch-1 hch-1 agr-1 agr-1 clec-78 clec-78 noah-2 noah-2 meg-3 meg-3 ptr-10 ptr-10 che-14 che-14 hpl-2 hpl-2 meg-1 meg-1 dcr-1 dcr-1 daf-16 daf-16 sma-9 sma-9 ptr-15 ptr-15 daf-9 daf-9 ptr-16 ptr-16 alg-3 alg-3 Y110A7A.7 Y110A7A.7 fog-2 fog-2 sri-40 sri-40 Y37A1B.7 Y37A1B.7 ptr-18 ptr-18 rps-4 rps-4 pqn-94 pqn-94 wrt-1 wrt-1 wrt-10 wrt-10 ptr-23 ptr-23 pgl-1 pgl-1 alg-4 alg-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lron-15ELRR (Extracellular Leucine-Rich Repeat) ONly. (1275 aa)
sid-1Systemic RNA interference defective protein 1; Plays a role in RNA-mediated gene silencing by acting cell- autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent. Belongs to the SID1 family. (776 aa)
C34E7.4Uncharacterized protein. (248 aa)
meg-4Uncharacterized protein. (832 aa)
sym-1SYM-1 protein. (680 aa)
ptr-4SSD domain-containing protein. (960 aa)
ptr-5SSD domain-containing protein. (961 aa)
ptr-6SSD domain-containing protein. (982 aa)
drh-3Dicer Related Helicase. (1119 aa)
prg-1Piwi-like protein; Belongs to the argonaute family. (824 aa)
glp-1Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. (1295 aa)
daf-12Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
F11E6.9Uncharacterized protein. (130 aa)
col-165Col_cuticle_N domain-containing protein. (335 aa)
prde-1piRNA biogenesis factor prde-1; Nuclear factor required for the production of piwi- interacting RNA (piRNA) precursors. Specifically required for piRNAs produced from loci associated with the Ruby motif. Promotes binding of the transcription factor snpc-4 at piRNA genomic clusters. Required for normal fertility. (526 aa)
cut-3ZP domain-containing protein. (389 aa)
ekl-1Uncharacterized protein. (606 aa)
daf-6SSD domain-containing protein. (913 aa)
hch-1Zinc metalloproteinase nas-34; Metalloprotease (By similarity). Required for normal hatching and migration of neuroblasts. May act by degrading eggshell proteins at hatching. (605 aa)
agr-1AGRin (Synaptic protein) homolog family member. (1473 aa)
clec-78C-type LECtin. (3514 aa)
noah-2NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A). (741 aa)
meg-3Uncharacterized protein. (862 aa)
ptr-10SSD domain-containing protein. (900 aa)
che-14SSD domain-containing protein. (917 aa)
hpl-2Chromo domain-containing protein. (303 aa)
meg-1Uncharacterized protein. (636 aa)
dcr-1Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. (1910 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
sma-9SMAll. (2232 aa)
ptr-15SSD domain-containing protein. (840 aa)
daf-9Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] (572 aa)
ptr-16SSD domain-containing protein. (898 aa)
alg-3Argonaute (Plant)-Like protein. (1035 aa)
Y110A7A.7Lipase_3 domain-containing protein. (312 aa)
fog-2F-box domain-containing protein. (327 aa)
sri-40Serpentine Receptor, class I. (320 aa)
Y37A1B.7Uncharacterized protein. (175 aa)
ptr-18SSD domain-containing protein. (895 aa)
rps-440S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family. (259 aa)
pqn-94Prion-like-(Q/N-rich)-domain-bearing protein. (109 aa)
wrt-1Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. (484 aa)
wrt-10WaRThog (Hedgehog-like family). (258 aa)
ptr-23SSD domain-containing protein. (983 aa)
pgl-1Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...] (771 aa)
alg-4Putative protein tag-76. (1040 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (12%) [HD]