STRINGSTRING
sym-4 sym-4 cut-3 cut-3 nep-11 nep-11 rrf-3 rrf-3 dex-1 dex-1 sym-3 sym-3 C46A5.4 C46A5.4 dyf-7 dyf-7 noah-1 noah-1 lin-35 lin-35 rol-3 rol-3 pxn-1 pxn-1 mlt-7 mlt-7 ptr-23 ptr-23 nep-1 nep-1 vps-26 vps-26 nep-21 nep-21 T06D8.10 T06D8.10 nep-2 nep-2 unc-119 unc-119 snt-2 snt-2 mec-8 mec-8 F49B2.6 F49B2.6 nid-1 nid-1 vps-35 vps-35 sur-5 sur-5 pxn-2 pxn-2 snt-1 snt-1 ehbp-1 ehbp-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sym-4SYM-4. (1043 aa)
cut-3ZP domain-containing protein. (389 aa)
nep-11Neprilysin-11; Probable cell surface protease; Belongs to the peptidase M13 family. (848 aa)
rrf-3RNA-dependent RNA polymerase Family. (1765 aa)
dex-1Dendrite extension defective protein 1; Along with dyf-7, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development. (1137 aa)
sym-3C2 NT-type domain-containing protein. (305 aa)
C46A5.4Uncharacterized protein. (1537 aa)
dyf-7Protein dyf-7; Required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating and dauer formation. Along with dex-1, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development. (446 aa)
noah-1NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A). (1052 aa)
lin-35Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] (961 aa)
rol-3Protein roller-3; Thought to have a role in developmental establishment of posterior morphology. (2481 aa)
pxn-1Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa)
mlt-7Peroxidase mlt-7 heavy chain; Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens. (724 aa)
ptr-23SSD domain-containing protein. (983 aa)
nep-1Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. (754 aa)
vps-26Vacuolar protein sorting-associated protein 26; May play a role in vesicular protein sorting, similar to the yeast retromer proteins. (410 aa)
nep-21Neprilysin-21; Probable cell surface protease. (856 aa)
T06D8.10Uncharacterized protein. (1490 aa)
nep-2Neprilysin-2; Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity. (736 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
snt-2Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (369 aa)
mec-8Mec-8 protein. (312 aa)
F49B2.6Aminopeptidase. (1082 aa)
nid-1NIDogen (Basement membrane protein). (1584 aa)
vps-35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (821 aa)
sur-5Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA (By similarity). Negatively regulates let-60 Ras activity during vulval induction. Belongs to the ATP-dependent AMP-binding enzyme family. (700 aa)
pxn-2PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa)
snt-1Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa)
ehbp-1EH (Eps-15-homology) domain Binding Protein family. (901 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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