Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]

Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.

Autophagy-related protein 3.

Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.

Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...]

Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.

Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.

Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.

ATG11 domain-containing protein.

Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.

Ubiquitin-like protein atg-12; Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin- like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg- 3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg- 3-atg-16 complex, required for lgg-1 lipidation; the comple [...]

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]

Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]

Autophagy-related protein 3.

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]

Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...]

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]

Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]

ATG11 domain-containing protein.

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]

Ubiquitin-like protein atg-12; Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin- like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg- 3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg- 3-atg-16 complex, required for lgg-1 lipidation; the comple [...]

Autophagy-related protein 3.

Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.

Autophagy-related protein 3.

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]

Autophagy-related protein 3.

Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...]

Autophagy-related protein 3.

Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.

Autophagy-related protein 3.

ATG11 domain-containing protein.

Autophagy-related protein 3.

Ubiquitin-like protein atg-12; Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin- like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg- 3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg- 3-atg-16 complex, required for lgg-1 lipidation; the comple [...]

Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...]

Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.

Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...]

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]