STRINGSTRING
ace-1 ace-1 ace-2 ace-2 hsp-16.2 hsp-16.2 ace-4 ace-4 gpx-4 gpx-4 spe-4 spe-4 skn-1 skn-1 gpx-5 gpx-5 gpx-3 gpx-3 hop-1 hop-1 E01A2.1 E01A2.1 ldh-1 ldh-1 gpx-1 gpx-1 sel-12 sel-12 gcs-1 gcs-1 gpx-8 gpx-8 gpx-7 gpx-7 gpx-2 gpx-2 daf-16 daf-16 gpx-6 gpx-6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ace-1Acetylcholinesterase 1; Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine. (620 aa)
ace-2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (629 aa)
hsp-16.2Heat shock protein Hsp-16.2; Belongs to the small heat shock protein (HSP20) family. (145 aa)
ace-4Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa)
gpx-4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (126 aa)
spe-4Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
gpx-5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
gpx-3Glutathione peroxidase 3; Belongs to the glutathione peroxidase family. (224 aa)
hop-1Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa)
E01A2.1Aldo_ket_red domain-containing protein. (290 aa)
ldh-1L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. LDH family. (336 aa)
gpx-1Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (163 aa)
sel-12Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa)
gcs-1Glutamate--cysteine ligase; Plays a role in resistance to arsenite. May play a role in the oxidative stress response induced by reactive oxygen species produced during infection by pathogenic bacteria. Together with trxr-1, required for the reduction of disulfide groups in the cuticle during molting. (654 aa)
gpx-8Glutathione PeroXidase. (145 aa)
gpx-7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
gpx-2Glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (179 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
gpx-6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (188 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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