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ahr-1 ahr-1 gpr-1 gpr-1 cyp-13A12 cyp-13A12 mboa-7 mboa-7 fat-7 fat-7 cyp-37A1 cyp-37A1 elo-3 elo-3 abf-2 abf-2 rps-2 rps-2 cyp-33E1 cyp-33E1 cyp-33C1 cyp-33C1 pmk-1 pmk-1 cht-1 cht-1 col-179 col-179 fipr-22 fipr-22 ilys-2 ilys-2 clec-60 clec-60 glp-4 glp-4 fat-1 fat-1 let-49 let-49 tac-1 tac-1 elo-8 elo-8 ace-2 ace-2 cyp-29A3 cyp-29A3 fat-3 fat-3 fat-5 fat-5 hlh-30 hlh-30 fat-2 fat-2 fat-6 fat-6 spp-12 spp-12 skn-1 skn-1 cyp-29A2 cyp-29A2 pho-4 pho-4 fkh-2 fkh-2 sut-1 sut-1 spp-2 spp-2 daf-16 daf-16 cnc-4 cnc-4 sek-1 sek-1 pst-1 pst-1 nhr-49 nhr-49 spp-14 spp-14 cyp-14A2 cyp-14A2 asg-1 asg-1 adr-1 adr-1 lys-6 lys-6 lys-5 lys-5 elo-7 elo-7 clec-67 clec-67 abf-3 abf-3 hot-1 hot-1 pmk-3 pmk-3 pmk-2 pmk-2 cyp-33E2 cyp-33E2 elo-5 elo-5 rbf-1 rbf-1 ada-2 ada-2 cyp-37B1 cyp-37B1 rps-23 rps-23
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ahr-1Aryl hydrocarbon receptor protein 1; Probable ligand-activated transcriptional activator. Acts as a transcriptional regulator in GABAergic motor neuron cell fate specification and development. Promotes cell-type-specific expression of guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance. Has no role in carbon dioxide avoidance. (602 aa)
gpr-1G-protein regulator 1; In the 1-cell embryo, probably together with gpr-2, controls nuclear rotation and spindle elongation during mitosis. Complex of gpr-1 and gpr-2, in association with lin- 5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement. (525 aa)
cyp-13A12CYtochrome P450 family; Belongs to the cytochrome P450 family. (518 aa)
mboa-7Lysophospholipid acyltransferase 7; Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acyl-sn-glycero-3-phosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA or eicosapentaenoic acid (EPA) as the acyl donor. Prefers sn-2-LPI rather than sn-1-LPI as the acyl acceptor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. (453 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
cyp-37A1CYtochrome P450 family; Belongs to the cytochrome P450 family. (508 aa)
elo-3Putative fatty acid elongation protein 3; Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth. Belongs to the ELO family. (320 aa)
abf-2Antibacterial factor-related peptide 2; Exhibits antimicrobial activity against the Gram-positive bacteria B.subtilis IFO 3134, K.varians MAFF 118076 and S.aureus ATCC 6538P, the Gram-negative bacteria A.tumefaciens MAFF 1001, B.bacteriovorus MAFF 106101 and K.pneumoniae MAFF 519002, and the yeasts C.krusei MAFF 114085, K.thermotolerans MAFF 113848 and T.delbrueckii MAFF 113811. (85 aa)
rps-240S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (272 aa)
cyp-33E1CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa)
cyp-33C1CYtochrome P450 family; Belongs to the cytochrome P450 family. (495 aa)
pmk-1Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
cht-1Probable endochitinase. (617 aa)
col-179Col_cuticle_N domain-containing protein. (283 aa)
fipr-22FIP (Fungus-Induced Protein) Related. (191 aa)
ilys-2Invertebrate-type lysozyme 2; Has bacteriolytic activity against Gram-positive bacteria (By similarity). May play a role in resistance to Gram-positive bacterium S.aureus infection. (139 aa)
clec-60VWFA domain-containing protein. (406 aa)
glp-4Valine--tRNA ligase. (1050 aa)
fat-1Omega-3 fatty acid desaturase fat-1; Omega-3 fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linolenic acid (18:2n-6), dihomo-gamma-linoleic acid (DHGLA) (20:3n-6), and arachidonic acid (20:4n-6), to generate gamma linolenic acid (18:3n-3), eicosatetraenoic acid (20:4n-3) and eicosapentaenoic acid (20:5n-3) respectively. Although the enzyme has been suggested to act on glycerolipids, the precise nature of the fatty acid substrate is unknown. (402 aa)
let-49Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (253 aa)
tac-1Transforming acid coiled-coil-containing protein 1; Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is requ [...] (260 aa)
elo-8Elongation of very long chain fatty acids protein. (292 aa)
ace-2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (629 aa)
cyp-29A3CYtochrome P450 family; Belongs to the cytochrome P450 family. (503 aa)
fat-3Delta(6)-fatty-acid desaturase fat-3; Delta(6) fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linoleic acid (Delta(9,12)- 18:2, or C18:2(n-6)) to gamma-linolenic acid (Delta(6,9,12)-18:3, or C18:3(n-6)). Plays a role in synaptic vesicle recycling by regulating synaptojanin unc-26 localization at synapses. (443 aa)
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
hlh-30BHLH domain-containing protein. (524 aa)
fat-2Delta(12) fatty acid desaturase fat-2; Catalyzes the desaturation of oleic acid (Delta(9)-18:1, or C18:1(n-9)) to linoleic acid (Delta(9,12)-18:2, or C18:2(n-6)). This desaturation event is essential for the synthesis of longer chain polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA, or C20:4(n-6)) and eicosapentaenoic acid (EPA, or C20:5(n-3)). (376 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
spp-12Saposin B-type domain-containing protein. (106 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
cyp-29A2CYtochrome P450 family. (503 aa)
pho-4Intestinal acid PHOsphatase; Belongs to the histidine acid phosphatase family. (452 aa)
fkh-2Fork-head domain-containing protein. (270 aa)
sut-1SUppressor of Tau pathology. (235 aa)
spp-2Saposin B-type domain-containing protein. (104 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
cnc-4CaeNaCin (Caenorhabditis bacteriocin). (66 aa)
sek-1Dual specificity mitogen-activated protein kinase kinase sek-1; Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir- 1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive [...] (336 aa)
pst-1Adenosine 3'-phospho 5'-phosphosulfate transporter 1; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity). (440 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
spp-14Saposin B-type domain-containing protein. (103 aa)
cyp-14A2CYtochrome P450 family; Belongs to the cytochrome P450 family. (492 aa)
asg-1Probable ATP synthase subunit g 1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism [...] (131 aa)
adr-1A-to-I RNA editing regulator adr-1; Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines. Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs. Represses editing efficiency of the Y75B8A.8 3' UTR in neurons. Required for correct expression and A-to-I editing of [...] (964 aa)
lys-6LYSozyme. (214 aa)
lys-5Lysozyme-like protein 5; Plays a role in resistance to Gram-positive bacteria S.aureus or B.thuringiensis infection. (215 aa)
elo-7Elongation of very long chain fatty acids protein. (309 aa)
clec-67C-type lectin domain-containing protein. (467 aa)
abf-3AntiBacterial Factor related. (89 aa)
hot-1Ly-6-related protein HOT-1. (218 aa)
pmk-3Mitogen-activated protein kinase pmk-3; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Involved in axon regeneration after injury, probably downstream of dlk-1 and mkk-4 and upstream of mak-2. May phosphorylate mak-2. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (474 aa)
pmk-2Mitogen-activated protein kinase pmk-2; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. (402 aa)
cyp-33E2CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa)
elo-5Elongation of very long chain fatty acids protein 5; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). Belongs to the ELO family. (274 aa)
rbf-1Rabphilin-1; Rab-3 effector. (1106 aa)
ada-2SANT domain-containing protein. (596 aa)
cyp-37B1CYtochrome P450 family; Belongs to the cytochrome P450 family. (509 aa)
rps-2340S ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family. (143 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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