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cup-5 cup-5 C29E4.10 C29E4.10 gba-1 gba-1 pgp-2 pgp-2 slc-17.2 slc-17.2 sul-3 sul-3 sul-2 sul-2 ncr-1 ncr-1 ppt-1 ppt-1 sul-1 sul-1 K09E4.4 K09E4.4 asah-1 asah-1 R04B3.2 R04B3.2 gana-1 gana-1 lipl-3 lipl-3 asp-4 asp-4 eri-1 eri-1 lipl-5 lipl-5 rab-35 rab-35 hpo-13 hpo-13 mlt-8 mlt-8 lrk-1 lrk-1 pgrn-1 pgrn-1 cln-3.2 cln-3.2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cup-5PKD_channel domain-containing protein. (668 aa)
C29E4.10Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. (645 aa)
gba-1Putative glucosylceramidase 1. (523 aa)
pgp-2p-GlycoProtein related. (1296 aa)
slc-17.2Uncharacterized transporter slc-17.2. (493 aa)
sul-3Sulfatase domain-containing protein. (488 aa)
sul-2Sulfatase domain-containing protein. (452 aa)
ncr-1NPC intracellular cholesterol transporter 1 homolog 1; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family. (1383 aa)
ppt-1Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides. (298 aa)
sul-1Putative extracellular sulfatase Sulf-1 homolog. (709 aa)
K09E4.4Uncharacterized protein. (715 aa)
asah-1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. (393 aa)
R04B3.2Putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. (363 aa)
gana-1Alpha-galactosidase. (451 aa)
lipl-3Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (404 aa)
asp-4Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family. (444 aa)
eri-13'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. (582 aa)
lipl-5Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (403 aa)
rab-35RAB family. (209 aa)
hpo-13Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (959 aa)
mlt-8Uncharacterized protein. (268 aa)
lrk-1Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2393 aa)
pgrn-1ProGRaNulin homolog. (358 aa)
cln-3.2Battenin. (435 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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