STRINGSTRING
syx-5 syx-5 rpl-2 rpl-2 rpl-19 rpl-19 hsp-70 hsp-70 copd-1 copd-1 hsp-3 hsp-3 rps-13 rps-13 tomm-40 tomm-40 unc-11 unc-11 atp-2 atp-2 C37C3.2 C37C3.2 elo-4 elo-4 hsp-90 hsp-90 dnj-7 dnj-7 fat-7 fat-7 hsp-1 hsp-1 rpl-26 rpl-26 vps-35 vps-35 math-33 math-33 sec-12 sec-12 sgt-1 sgt-1 pde-2 pde-2 rpl-9 rpl-9 xbp-1 xbp-1 rps-16 rps-16 rps-19 rps-19 nuo-2 nuo-2 vps-26 vps-26 act-5 act-5 hsp-16.11 hsp-16.11 hsp-16.48 hsp-16.48 hsp-16.1 hsp-16.1 fat-6 fat-6 fat-5 fat-5 pod-2 pod-2 tomm-22 tomm-22 sec-23 sec-23 xrn-1 xrn-1 hsp-16.2 hsp-16.2 nuo-3 nuo-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
syx-5Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (413 aa)
rpl-260S ribosomal protein L8. (260 aa)
rpl-1960S ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (198 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
copd-1Probable coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (515 aa)
hsp-3Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa)
rps-1340S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (151 aa)
tomm-40Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria. Specifically required for nnt-1 accumulation in the mitochondria and may be involved in the secretion of daf-28/insulin from the mitochondria. Required for embryonic and larval development. (301 aa)
unc-11Phosphatidylinositol-binding clathrin assembly protein unc-11; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. Belongs to the PICALM/SNAP91 family. (657 aa)
atp-2ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (538 aa)
C37C3.2Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). (436 aa)
elo-4Putative fatty acid elongation protein 4; Could be implicated in synthesis of very long chain fatty acids; Belongs to the ELO family. (291 aa)
hsp-90Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa)
dnj-7DNaJ domain (Prokaryotic heat shock protein). (491 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
hsp-1Heat shock 70 kDa protein A. (640 aa)
rpl-2660S ribosomal protein L26. (142 aa)
vps-35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (821 aa)
math-33Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. (1138 aa)
sec-12WD_REPEATS_REGION domain-containing protein. (425 aa)
sgt-1Small Glutamine-rich Tetratrico repeat protein. (337 aa)
pde-2Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size. (831 aa)
rpl-960S ribosomal protein L9; Belongs to the universal ribosomal protein uL6 family. (189 aa)
xbp-1BZIP domain-containing protein. (335 aa)
rps-1640S ribosomal protein S16. (144 aa)
rps-1940S ribosomal protein S19; Belongs to the eukaryotic ribosomal protein eS19 family. (146 aa)
nuo-2Complex1_30kDa domain-containing protein; Belongs to the complex I 30 kDa subunit family. (268 aa)
vps-26Vacuolar protein sorting-associated protein 26; May play a role in vesicular protein sorting, similar to the yeast retromer proteins. (410 aa)
act-5ACTin. (375 aa)
hsp-16.11Heat shock protein Hsp-16.1/Hsp-16.11. (145 aa)
hsp-16.48Heat shock protein Hsp-16.48/Hsp-16.49; Belongs to the small heat shock protein (HSP20) family. (143 aa)
hsp-16.1Heat shock protein Hsp-16.1/Hsp-16.11. (145 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
pod-2Uncharacterized protein. (2165 aa)
tomm-22Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with the peripheral receptor tomm-20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. (109 aa)
sec-23Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (821 aa)
xrn-15'-3' exoribonuclease 1. (1591 aa)
hsp-16.2Heat shock protein Hsp-16.2; Belongs to the small heat shock protein (HSP20) family. (145 aa)
nuo-3NADH Ubiquinone Oxidoreductase. (131 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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