STRINGSTRING
bre-5 bre-5 asp-4 asp-4 nra-2 nra-2 cal-4 cal-4 cmd-1 cmd-1 act-5 act-5 ncx-1 ncx-1 crt-1 crt-1 mca-3 mca-3 plk-2 plk-2 nck-1 nck-1 unc-32 unc-32 B0563.7 B0563.7 erm-1 erm-1 tax-6 tax-6 clp-1 clp-1 cal-1 cal-1 cal-2 cal-2 cdh-8 cdh-8 vha-12 vha-12 rab-5 rab-5 itr-1 itr-1 cal-7 cal-7 soc-1 soc-1 K03A1.4 K03A1.4 dbn-1 dbn-1 unc-68 unc-68 sca-1 sca-1 tra-3 tra-3 cal-3 cal-3 sek-1 sek-1 inx-16 inx-16
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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bre-5Beta-1,3-galactosyltransferase bre-5; Transfers N-acetylgalactosamine onto mannose groups of carbohydrate substrates. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3, and bre-4. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2. (322 aa)
asp-4Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family. (444 aa)
nra-2Nicalin; Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER). In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER. Specifically, may promote the inclusion of alpha subunits unc-38 and unc-29 into L-AChR. Regulates L- AChR sensitivity to agonists such as nicotine and levamisole at neuro- muscular junctions. In touch neurons, may prevent ER exit of incorrectly folded mec-4-mec-10 ion channel ; Belongs to the [...] (563 aa)
cal-4CALmodulin related genes. (236 aa)
cmd-1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
act-5ACTin. (375 aa)
ncx-1Sodium-calcium exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (880 aa)
crt-1Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegen [...] (395 aa)
mca-3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1234 aa)
plk-2Serine/threonine-protein kinase plk-2; Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor- [...] (632 aa)
nck-1NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. (395 aa)
unc-32Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development. (905 aa)
B0563.7Uncharacterized calcium-binding protein B0563.7. (229 aa)
erm-1FERM domain-containing protein. (564 aa)
tax-6Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] (545 aa)
clp-1Calpain clp-1; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates (By similarity). Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle. Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death. (780 aa)
cal-1Calmodulin-like protein; This protein resembles calmodulin in sequence but possibly resembles troponin C in function. (180 aa)
cal-2CALmodulin related genes. (171 aa)
cdh-8CaDHerin family. (1684 aa)
vha-12Probable V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). Required for necrotic cell death and epidermal cell fusion. (491 aa)
rab-5RAB family. (208 aa)
itr-1Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa)
cal-7EF-hand domain-containing protein. (179 aa)
soc-1Multisubstrate adapter protein soc-1; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases. Plays a role in fluid homeostasis, probably downstream of receptor egl-15 and upstream of let-60/Ras. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole and gamma- aminobutyric acid (GABA)receptor-mediated sensitivity to muscimol. Regulates synaptic levels of nAchR receptor subunit lev-1 and unc-38, and GABA receptor subunit unc-49 in the nerve cord, probably downstream of egl-15. Regulates motility. During the [...] (430 aa)
K03A1.4EF-hand domain-containing protein. (184 aa)
dbn-1Drebrin-like protein. (643 aa)
unc-68Uncharacterized protein. (5202 aa)
sca-1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa)
tra-3Calpain-5; Required for the correct female sexual development of the soma and germline in hermaphrodite animals, while being fully dispensable in males. Has calcium-dependent proteolytic activity and is involved in the cleavage of tra-2, for which it acts as a potentiator. Capable of calcium-dependent autolysis. Part of the necrosis cell death pathway. Required for necrosis of intestinal cells induced by B.thuringiensis endotoxin Cry6Aa ; Belongs to the peptidase C2 family. (648 aa)
cal-3CALmodulin related genes. (234 aa)
sek-1Dual specificity mitogen-activated protein kinase kinase sek-1; Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir- 1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive [...] (336 aa)
inx-16Innexin-16; Structural component of the gap junctions (By similarity). Required for signals downstream of defecation clock. Belongs to the pannexin family. (372 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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