STRINGSTRING
fat-5 fat-5 fat-6 fat-6 fat-2 fat-2 hlh-30 hlh-30 fat-3 fat-3 ptc-3 ptc-3 mig-1 mig-1 acdh-11 acdh-11 hsp-16.2 hsp-16.2 sbp-1 sbp-1 hsf-1 hsf-1 fat-1 fat-1 ptr-23 ptr-23 hsp-70 hsp-70 dpy-8 dpy-8 ptr-4 ptr-4 nhr-64 nhr-64 hsp-90 hsp-90 str-2 str-2 fat-7 fat-7 elo-2 elo-2 acs-2 acs-2 dpy-7 dpy-7 ptr-24 ptr-24 mul-1 mul-1 hsp-17 hsp-17 dgat-2 dgat-2 nhr-80 nhr-80 rde-1 rde-1 nhr-49 nhr-49 osm-8 osm-8 mdt-15 mdt-15 rol-6 rol-6 fat-4 fat-4 dpy-10 dpy-10 dpy-9 dpy-9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
fat-2Delta(12) fatty acid desaturase fat-2; Catalyzes the desaturation of oleic acid (Delta(9)-18:1, or C18:1(n-9)) to linoleic acid (Delta(9,12)-18:2, or C18:2(n-6)). This desaturation event is essential for the synthesis of longer chain polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA, or C20:4(n-6)) and eicosapentaenoic acid (EPA, or C20:5(n-3)). (376 aa)
hlh-30BHLH domain-containing protein. (524 aa)
fat-3Delta(6)-fatty-acid desaturase fat-3; Delta(6) fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linoleic acid (Delta(9,12)- 18:2, or C18:2(n-6)) to gamma-linolenic acid (Delta(6,9,12)-18:3, or C18:3(n-6)). Plays a role in synaptic vesicle recycling by regulating synaptojanin unc-26 localization at synapses. (443 aa)
ptc-3Protein patched homolog 3; Regulates osmosis during embryonic development. Required for larval development and in particular is involved in larval molting. Belongs to the patched family. (1367 aa)
mig-1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
acdh-11Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. (617 aa)
hsp-16.2Heat shock protein Hsp-16.2; Belongs to the small heat shock protein (HSP20) family. (145 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
hsf-1HSF_DOMAIN domain-containing protein. (671 aa)
fat-1Omega-3 fatty acid desaturase fat-1; Omega-3 fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linolenic acid (18:2n-6), dihomo-gamma-linoleic acid (DHGLA) (20:3n-6), and arachidonic acid (20:4n-6), to generate gamma linolenic acid (18:3n-3), eicosatetraenoic acid (20:4n-3) and eicosapentaenoic acid (20:5n-3) respectively. Although the enzyme has been suggested to act on glycerolipids, the precise nature of the fatty acid substrate is unknown. (402 aa)
ptr-23SSD domain-containing protein. (983 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
dpy-8Col_cuticle_N domain-containing protein. (452 aa)
ptr-4SSD domain-containing protein. (960 aa)
nhr-64Nuclear hormone receptor family member nhr-64; Orphan nuclear receptor. (375 aa)
hsp-90Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa)
str-2Seven transmembrane receptor 2. (358 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
elo-2Elongation of very long chain fatty acids protein. (274 aa)
acs-2Fatty Acid CoA Synthetase family. (618 aa)
dpy-7Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape. (318 aa)
ptr-24SSD domain-containing protein. (892 aa)
mul-1Mucin Like protein. (259 aa)
hsp-17SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (149 aa)
dgat-2Acyl-CoA:DiacylGlycerol AcylTransferase. (345 aa)
nhr-80Nuclear Hormone Receptor family. (504 aa)
rde-1RNA interference promoting factor RDE-1. (1020 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
osm-8Osmotic avoidance abnormal protein 8; Negative regulator of the osmotic stress response. Acts via the transmembrane protein ptr-23. (331 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
fat-4Delta(5) fatty acid desaturase fat-4; Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) to generate arachidonic acid (20:4n-6). Also acts on a number of other substrates, including fatty acids that do not contain a double bond at the 8 position; Belongs to the fatty acid desaturase type 1 family. (447 aa)
dpy-10Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa)
dpy-9Col_cuticle_N domain-containing protein. (315 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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