STRINGSTRING
bpl-1 bpl-1 pmk-1 pmk-1 jnk-1 jnk-1 maoc-1 maoc-1 acox-1.1 acox-1.1 fat-7 fat-7 daf-12 daf-12 acs-2 acs-2 fasn-1 fasn-1 mek-1 mek-1 nhr-49 nhr-49 sek-1 sek-1 cpt-2 cpt-2 mdt-15 mdt-15 daf-16 daf-16 fat-4 fat-4 skn-1 skn-1 dbl-1 dbl-1 fat-6 fat-6 fat-5 fat-5 daf-2 daf-2 daf-22 daf-22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bpl-1BPL/LPL catalytic domain-containing protein. (1215 aa)
pmk-1Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
jnk-1Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] (463 aa)
maoc-1MAO-C-like dehydratase domain. (298 aa)
acox-1.1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (674 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
daf-12Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa)
acs-2Fatty Acid CoA Synthetase family. (618 aa)
fasn-1Carrier domain-containing protein. (2613 aa)
mek-1Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] (347 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
sek-1Dual specificity mitogen-activated protein kinase kinase sek-1; Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir- 1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive [...] (336 aa)
cpt-2Calponin-homology (CH) domain-containing protein. (646 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
fat-4Delta(5) fatty acid desaturase fat-4; Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) to generate arachidonic acid (20:4n-6). Also acts on a number of other substrates, including fatty acids that do not contain a double bond at the 8 position; Belongs to the fatty acid desaturase type 1 family. (447 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
dbl-1TGF_BETA_2 domain-containing protein. (365 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
daf-22Non-specific lipid-transfer protein-like 2; Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone. Belongs to the thiolase-like superfamily. Thiolase family. (412 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.