node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
daf-16 | daf-28 | R13H8.1h.1 | Y116F11B.1.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Uncharacterized protein. | 0.809 |
daf-16 | ins-39 | R13H8.1h.1 | F21E9.4.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | INSulin related. | 0.422 |
daf-28 | daf-16 | Y116F11B.1.1 | R13H8.1h.1 | Uncharacterized protein. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.809 |
daf-28 | ins-3 | Y116F11B.1.1 | ZK75.3.1 | Uncharacterized protein. | Probable insulin-like peptide beta-type 3. | 0.765 |
daf-28 | ins-39 | Y116F11B.1.1 | F21E9.4.1 | Uncharacterized protein. | INSulin related. | 0.806 |
grl-15 | grl-16 | Y75B8A.20.1 | Y65B4BR.6b.1 | Ground-like domain-containing protein. | Ground-like domain-containing protein. | 0.468 |
grl-15 | qua-1 | Y75B8A.20.1 | T05C12.10.1 | Ground-like domain-containing protein. | Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. | 0.475 |
grl-15 | wrt-1 | Y75B8A.20.1 | ZK1290.12.1 | Ground-like domain-containing protein. | Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. | 0.935 |
grl-16 | grl-15 | Y65B4BR.6b.1 | Y75B8A.20.1 | Ground-like domain-containing protein. | Ground-like domain-containing protein. | 0.468 |
grl-16 | qua-1 | Y65B4BR.6b.1 | T05C12.10.1 | Ground-like domain-containing protein. | Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. | 0.441 |
grl-16 | wrt-1 | Y65B4BR.6b.1 | ZK1290.12.1 | Ground-like domain-containing protein. | Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. | 0.790 |
ins-3 | daf-28 | ZK75.3.1 | Y116F11B.1.1 | Probable insulin-like peptide beta-type 3. | Uncharacterized protein. | 0.765 |
ins-39 | daf-16 | F21E9.4.1 | R13H8.1h.1 | INSulin related. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.422 |
ins-39 | daf-28 | F21E9.4.1 | Y116F11B.1.1 | INSulin related. | Uncharacterized protein. | 0.806 |
ptd-2 | wrt-1 | F07C3.1.1 | ZK1290.12.1 | SSD domain-containing protein. | Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. | 0.680 |
ptd-2 | wrt-3 | F07C3.1.1 | F38E11.7a.1 | SSD domain-containing protein. | Warthog protein 3; Intercellular signal essential for a variety of patterning events during development. | 0.475 |
qua-1 | grl-15 | T05C12.10.1 | Y75B8A.20.1 | Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. | Ground-like domain-containing protein. | 0.475 |
qua-1 | grl-16 | T05C12.10.1 | Y65B4BR.6b.1 | Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. | Ground-like domain-containing protein. | 0.441 |
qua-1 | wrt-1 | T05C12.10.1 | ZK1290.12.1 | Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. | Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. | 0.623 |
wrt-1 | grl-15 | ZK1290.12.1 | Y75B8A.20.1 | Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. | Ground-like domain-containing protein. | 0.935 |