STRINGSTRING
scp-1 scp-1 ncr-1 ncr-1 ptd-2 ptd-2 ins-39 ins-39 wrt-3 wrt-3 daf-16 daf-16 qua-1 qua-1 daf-28 daf-28 grl-16 grl-16 grl-15 grl-15 wrt-1 wrt-1 ptr-23 ptr-23 ins-3 ins-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
scp-1SREBP Cleavage activating Protein (SCAP) homolog. (1087 aa)
ncr-1NPC intracellular cholesterol transporter 1 homolog 1; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family. (1383 aa)
ptd-2SSD domain-containing protein. (936 aa)
ins-39INSulin related. (126 aa)
wrt-3Warthog protein 3; Intercellular signal essential for a variety of patterning events during development. (179 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
qua-1Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. (1169 aa)
daf-28Uncharacterized protein. (97 aa)
grl-16Ground-like domain-containing protein. (453 aa)
grl-15Ground-like domain-containing protein. (169 aa)
wrt-1Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. (484 aa)
ptr-23SSD domain-containing protein. (983 aa)
ins-3Probable insulin-like peptide beta-type 3. (107 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (28%) [HD]