STRINGSTRING
ubc-12 ubc-12 C17D12.5 C17D12.5 C28G1.10 C28G1.10 ubc-1 ubc-1 ubc-6 ubc-6 ubc-25 ubc-25 uev-3 uev-3 ubc-9 ubc-9 uev-1 uev-1 ubc-20 ubc-20 ubc-24 ubc-24 uev-2 uev-2 ubc-7 ubc-7 let-70 let-70 ubc-18 ubc-18 ubc-26 ubc-26 ubc-15 ubc-15 ubc-16 ubc-16 ubc-13 ubc-13 ubc-19 ubc-19 ubc-3 ubc-3 ubc-14 ubc-14 ubc-8 ubc-8 ubc-17 ubc-17 ubc-21 ubc-21 ubc-22 ubc-22 tsg-101 tsg-101
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ubc-12NEDD8-conjugating enzyme ubc-12; Accepts the ubiquitin-like protein NEDD8 from the uba-3-ula-1 E1 complex and catalyzes its covalent attachment to other proteins. Plays a role in male tail tip morphogenesis. (180 aa)
C17D12.5Uncharacterized protein. (139 aa)
C28G1.10UBIQUITIN_CONJUGAT_2 domain-containing protein. (203 aa)
ubc-1Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
ubc-6UBIQUITIN_CONJUGAT_2 domain-containing protein. (314 aa)
ubc-25Ubiquitin-conjugating enzyme E2 25; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Required for the maintenance of neuromuscular function. (387 aa)
uev-3Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination (By similarity). May modulate the activity of the p38 MAP kinase pnk-3. May have a role in axon termination and synaptic transmission at motor and mechanosensory neurons. Plays a role in intraflagellar transport in cilia and cilium length regulation ; Belongs to the ubiquitin-conjugating enzyme family. (368 aa)
ubc-9SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
uev-1Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...] (139 aa)
ubc-20UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
ubc-24UBIQUITIN_CONJUGAT_2 domain-containing protein. (160 aa)
uev-2UBIQUITIN_CONJUGAT_2 domain-containing protein. (230 aa)
ubc-7Probable ubiquitin-conjugating enzyme E2 7; Catalyzes the covalent attachment of ubiquitin to other proteins. (164 aa)
let-70Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Mediates the selective degradation of short- lived and abnormal proteins. Plays a role in the DNA damage response. In particular, in response to ionizing radiation, associates with the E3 ubiquitin-protein ligase brc-1-brd-1 heterodimer on chromatin to activate E3-ubiquitin ligase activity of the heterodimer, and thus its DNA damage repair mechanisms ; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
ubc-18UBIQUITIN_CONJUGAT_2 domain-containing protein. (153 aa)
ubc-26UBIQUITIN_CONJUGAT_2 domain-containing protein. (238 aa)
ubc-15UBIQUITIN_CONJUGAT_2 domain-containing protein. (551 aa)
ubc-16Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Together with ubc-18, required for the ubiquitination of membranous organelles, and the removal of paternal mitochondria from early embryos. (152 aa)
ubc-13Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. (151 aa)
ubc-19UBIQUITIN_CONJUGAT_2 domain-containing protein. (292 aa)
ubc-3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (243 aa)
ubc-14UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
ubc-8UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (216 aa)
ubc-17Probable ubiquitin-conjugating enzyme protein 17; Belongs to the ubiquitin-conjugating enzyme family. (728 aa)
ubc-21Probable ubiquitin-conjugating enzyme E2 21; Catalyzes the covalent attachment of ubiquitin to other proteins. (214 aa)
ubc-22UBiquitin Conjugating enzyme. (182 aa)
tsg-101Tumor Susceptibility Gene homolog. (425 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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