STRINGSTRING
B0303.4 B0303.4 C16C8.11 C16C8.11 C16C8.13 C16C8.13 C16C8.14 C16C8.14 C16C8.16 C16C8.16 ZK688.5 ZK688.5 rad-23 rad-23 ubq-2 ubq-2 prp-21 prp-21 T28A11.22 T28A11.22 smo-1 smo-1 K10C2.12 K10C2.12 ubl-1 ubl-1 F56F3.4 F56F3.4 F52C6.3 F52C6.3 F52C6.2 F52C6.2 ned-8 ned-8 tag-353 tag-353 ubq-1 ubq-1 ubql-1 ubql-1 F14D2.11 F14D2.11 rps-30 rps-30 C16C8.5 C16C8.5 C16C8.4 C16C8.4 C16C8.20 C16C8.20 usp-14 usp-14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B0303.4Uncharacterized protein B0303.4. (616 aa)
C16C8.11Ubiquitin-like domain-containing protein. (214 aa)
C16C8.13Ubiquitin-like domain-containing protein. (244 aa)
C16C8.14Ubiquitin-like domain-containing protein. (233 aa)
C16C8.16Ubiquitin-like domain-containing protein. (267 aa)
ZK688.5Uncharacterized protein ZK688.5. (1620 aa)
rad-23Uncharacterized protein. (323 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
prp-21Yeast PRP (Splicing factor) related. (655 aa)
T28A11.22Ubiquitin-like domain-containing protein. (170 aa)
smo-1Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa)
K10C2.12Ubiquitin-like domain-containing protein. (88 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
F56F3.4Uncharacterized protein. (341 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
ned-8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. (77 aa)
tag-353Ubiquitin-like domain-containing protein. (361 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
ubql-1Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] (502 aa)
F14D2.11Ubiquitin-like domain-containing protein. (195 aa)
rps-3040S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (130 aa)
C16C8.5Ubiquitin-like domain-containing protein. (180 aa)
C16C8.4Ubiquitin-like domain-containing protein. (226 aa)
C16C8.20Ubiquitin-like domain-containing protein. (145 aa)
usp-14Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity). Belongs to the peptidase C19 family. USP14/UBP6 subfamily. (489 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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