node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdc-25.1 | cdc-25.2 | K06A5.7.2 | F16B4.8a.1 | M-phase inducer phosphatase cdc-25.1. | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. | 0.639 |
cdc-25.1 | cdc-25.3 | K06A5.7.2 | ZK637.11.1 | M-phase inducer phosphatase cdc-25.1. | M-phase inducer phosphatase cdc-25.3. | 0.617 |
cdc-25.1 | cdc-25.4 | K06A5.7.2 | R05H5.2.1 | M-phase inducer phosphatase cdc-25.1. | Rhodanese domain-containing protein. | 0.538 |
cdc-25.1 | vhp-1 | K06A5.7.2 | F08B1.1e.1 | M-phase inducer phosphatase cdc-25.1. | Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.479 |
cdc-25.2 | cdc-25.1 | F16B4.8a.1 | K06A5.7.2 | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. | M-phase inducer phosphatase cdc-25.1. | 0.639 |
cdc-25.2 | cdc-25.3 | F16B4.8a.1 | ZK637.11.1 | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. | M-phase inducer phosphatase cdc-25.3. | 0.532 |
cdc-25.2 | cdc-25.4 | F16B4.8a.1 | R05H5.2.1 | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. | Rhodanese domain-containing protein. | 0.593 |
cdc-25.3 | cdc-25.1 | ZK637.11.1 | K06A5.7.2 | M-phase inducer phosphatase cdc-25.3. | M-phase inducer phosphatase cdc-25.1. | 0.617 |
cdc-25.3 | cdc-25.2 | ZK637.11.1 | F16B4.8a.1 | M-phase inducer phosphatase cdc-25.3. | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. | 0.532 |
cdc-25.3 | cdc-25.4 | ZK637.11.1 | R05H5.2.1 | M-phase inducer phosphatase cdc-25.3. | Rhodanese domain-containing protein. | 0.611 |
cdc-25.4 | cdc-25.1 | R05H5.2.1 | K06A5.7.2 | Rhodanese domain-containing protein. | M-phase inducer phosphatase cdc-25.1. | 0.538 |
cdc-25.4 | cdc-25.2 | R05H5.2.1 | F16B4.8a.1 | Rhodanese domain-containing protein. | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. | 0.593 |
cdc-25.4 | cdc-25.3 | R05H5.2.1 | ZK637.11.1 | Rhodanese domain-containing protein. | M-phase inducer phosphatase cdc-25.3. | 0.611 |
lip-1 | vhp-1 | C05B10.1b.1 | F08B1.1e.1 | Dual specificity protein phosphatase lip-1; Dephosphorylates MAP kinase mpk-1. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.919 |
moc-3 | mpst-1 | F42G8.6.1 | D2023.5.1 | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | Putative thiosulfate sulfurtransferase mpst-1. | 0.956 |
moc-3 | mpst-2 | F42G8.6.1 | H12D21.4.1 | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | Sulfurtransferase. | 0.954 |
moc-3 | mpst-3 | F42G8.6.1 | H12D21.7b.1 | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | MercaptoPyruvate SulfurTransferase homolog. | 0.562 |
moc-3 | mpst-4 | F42G8.6.1 | F11G11.9.1 | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | Thiosulfate/3-mercaptopyruvate sulfurtransferase. | 0.954 |
moc-3 | mpst-5 | F42G8.6.1 | Y59H11AM.2.1 | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | Putative thiosulfate sulfurtransferase mpst-4. | 0.562 |
moc-3 | mpst-6 | F42G8.6.1 | Y59H11AM.3.1 | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | MercaptoPyruvate SulfurTransferase homolog. | 0.562 |