STRINGSTRING
B0272.3 B0272.3 B0303.3 B0303.3 stdh-1 stdh-1 stdh-3 stdh-3 art-1 art-1 ech-1.1 ech-1.1 elo-4 elo-4 let-767 let-767 elo-3 elo-3 ech-8 ech-8 ech-9 ech-9 stdh-2 stdh-2 elo-2 elo-2 stdh-4 stdh-4 elo-5 elo-5 elo-6 elo-6 ppt-1 ppt-1 acaa-2 acaa-2 F54C8.1 F54C8.1 elo-1 elo-1 hacd-1 hacd-1 ech-6 ech-6 ech-1.2 ech-1.2 hpo-8 hpo-8 mecr-1 mecr-1 ech-7 ech-7 Y48A6B.9 Y48A6B.9 elo-9 elo-9
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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B0272.3Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (309 aa)
B0303.3Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. (448 aa)
stdh-1Putative steroid dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (314 aa)
stdh-3Putative steroid dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa)
art-1Probable very-long-chain enoyl-CoA reductase art-1; Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precurso [...] (308 aa)
ech-1.1Enoyl-CoA Hydratase. (755 aa)
elo-4Putative fatty acid elongation protein 4; Could be implicated in synthesis of very long chain fatty acids; Belongs to the ELO family. (291 aa)
let-767Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (337 aa)
elo-3Putative fatty acid elongation protein 3; Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth. Belongs to the ELO family. (320 aa)
ech-8Enoyl-CoA Hydratase. (437 aa)
ech-9Enoyl-CoA Hydratase. (434 aa)
stdh-2Putative steroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa)
elo-2Elongation of very long chain fatty acids protein. (274 aa)
stdh-4Putative steroid dehydrogenase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (317 aa)
elo-5Elongation of very long chain fatty acids protein 5; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). Belongs to the ELO family. (274 aa)
elo-6Elongation of very long chain fatty acids protein 6; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isoheptadecanoate (C17iso). (274 aa)
ppt-1Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides. (298 aa)
acaa-2ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
F54C8.1Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (298 aa)
elo-1Elongation of very long chain fatty acids protein. (288 aa)
hacd-1Hydroxy-Acyl-CoA Dehydrogenase. (299 aa)
ech-6Probable enoyl-CoA hydratase, mitochondrial. (288 aa)
ech-1.2Enoyl-CoA Hydratase. (781 aa)
hpo-8Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precu [...] (218 aa)
mecr-1Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (344 aa)
ech-7Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa)
Y48A6B.9Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (346 aa)
elo-9Elongation of very long chain fatty acids protein. (286 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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