STRINGSTRING
gna-1 gna-1 C01F1.3 C01F1.3 cht-1 cht-1 C05C8.7 C05C8.7 C36A4.4 C36A4.4 tag-335 tag-335 gale-1 gale-1 bre-1 bre-1 sqv-1 sqv-1 gfat-1 gfat-1 hxk-1 hxk-1 F21D5.1 F21D5.1 gfat-2 gfat-2 sqv-4 sqv-4 chs-2 chs-2 F52B11.2 F52B11.2 gmd-2 gmd-2 F59B2.3 F59B2.3 K03H1.13 K03H1.13 K08E3.5 K08E3.5 ger-1 ger-1 R05F9.6 R05F9.6 T03F6.3 T03F6.3 T05H4.4 T05H4.4 hpo-19 hpo-19 hex-1 hex-1 chs-1 chs-1 W06B4.2 W06B4.2 cht-4 cht-4 Y43F4B.5 Y43F4B.5 Y47D9A.1 Y47D9A.1 Y52B11A.3 Y52B11A.3 gpi-1 gpi-1 ZK1058.3 ZK1058.3 ZK632.4 ZK632.4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gna-1Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily. (165 aa)
C01F1.3NAD(P)-bd_dom domain-containing protein. (631 aa)
cht-1Probable endochitinase. (617 aa)
C05C8.7Uncharacterized protein. (467 aa)
C36A4.4Probable UDP-N-acetylglucosamine pyrophosphorylase. (484 aa)
tag-335Mannose-1-phosphate guanyltransferase beta; Belongs to the transferase hexapeptide repeat family. (365 aa)
gale-1UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] (349 aa)
bre-1GDP-mannose 4,6 dehydratase 1; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. Involved in susceptibility to pore- forming crystal toxins in conjunction with bre-2, bre-3, bre-4, and bre-5. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of N-glycans to which Cgl2 binds. Has a role in determining brood size. Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (399 aa)
sqv-1NAD(P)-bd_dom domain-containing protein. (467 aa)
gfat-1Glutamine-Fructose 6-phosphate AminoTransferase homolog. (725 aa)
hxk-1Phosphotransferase; Belongs to the hexokinase family. (500 aa)
F21D5.1Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (550 aa)
gfat-2Glutamine-Fructose 6-phosphate AminoTransferase homolog. (710 aa)
sqv-4UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (481 aa)
chs-2Chitin synthase chs-2; May be involved in chitin synthesis in the pharynx during larval development; Belongs to the chitin synthase family. Class IV subfamily. (1700 aa)
F52B11.2Probable phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions; Belongs to the eukaryotic PMM family. (254 aa)
gmd-2GDP-mannose 4,6 dehydratase 2; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (382 aa)
F59B2.3N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family. (418 aa)
K03H1.13Fucokinase domain-containing protein. (464 aa)
K08E3.5UTP--glucose-1-phosphate uridylyltransferase. (522 aa)
ger-1GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. (315 aa)
R05F9.6Uncharacterized protein; Belongs to the phosphohexose mutase family. (568 aa)
T03F6.3Probable glucosamine-6-phosphate isomerase. (267 aa)
T05H4.4NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (303 aa)
hpo-19NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (309 aa)
hex-1Beta-hexosaminidase A; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose. (555 aa)
chs-1Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell. (1322 aa)
W06B4.2BcrAD_BadFG domain-containing protein. (521 aa)
cht-4Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (360 aa)
Y43F4B.5Uncharacterized protein; Belongs to the phosphohexose mutase family. (595 aa)
Y47D9A.1NTP_transferase domain-containing protein. (401 aa)
Y52B11A.3Uncharacterized protein. (552 aa)
gpi-1Glucose-6-phosphate isomerase; Belongs to the GPI family. (586 aa)
ZK1058.3Probable galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (352 aa)
ZK632.4Probable mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (416 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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