Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C34B7.2 | daf-18 | C34B7.2.1 | T07A9.6.1 | SAC domain-containing protein. | Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly, [...] | 0.471 |
| C34B7.2 | mtm-1 | C34B7.2.1 | Y110A7A.5.1 | SAC domain-containing protein. | Myotubularin-related protein 1; Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles. Negatively regulates phagocytosis of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex. In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane. Essential for embryonic and larval development. May promote migration of distal tip cells ; B [...] | 0.972 |
| C34B7.2 | mtm-3 | C34B7.2.1 | T24A11.1a.1 | SAC domain-containing protein. | Myotubularin-related protein 3; Preferentially dephosphorylates phosphatidylinositol 3- phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation. Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination. | 0.975 |
| C34B7.2 | mtm-6 | C34B7.2.1 | F53A2.8b.2 | SAC domain-containing protein. | Myotubularin-related protein 6; May dephosphorylate phosphatidylinositol-3-phosphate (PI3P). In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels. Regulates fluid phase endocytosis in coelomocytes. Controls the endosomal localization of sorting nexin snx-3 and the levels of sorting receptor mig-14. By regulating the retrograde transport of mig-14, may be involved in the secretion of Wnt ligands such as egl-20. Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast d [...] | 0.964 |
| C34B7.2 | pifk-1 | C34B7.2.1 | F35H12.4.1 | SAC domain-containing protein. | PhosphoInositide Four Kinase (PI-4 Kinase); Belongs to the PI3/PI4-kinase family. | 0.471 |
| C34B7.2 | piki-1 | C34B7.2.1 | F39B1.1.1 | SAC domain-containing protein. | Phosphatidylinositol 3-kinase piki-1; Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3- phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes; Belongs to the PI3/PI4-kinase family. | 0.531 |
| C34B7.2 | ppk-3 | C34B7.2.1 | VF11C1L.1.1 | SAC domain-containing protein. | PIP Kinase. | 0.996 |
| C34B7.2 | unc-26 | C34B7.2.1 | JC8.10b.1 | SAC domain-containing protein. | Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. | 0.483 |
| C34B7.2 | vps-34 | C34B7.2.1 | B0025.1a.1 | SAC domain-containing protein. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] | 0.955 |
| C54E4.5 | inos-1 | C54E4.5.1 | VF13D12L.1.1 | Uncharacterized protein. | Inos-1-P_synth domain-containing protein. | 0.518 |
| C54E4.5 | pisy-1 | C54E4.5.1 | Y46G5A.5.1 | Uncharacterized protein. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. | 0.906 |
| C56A3.8 | W09C5.7 | C56A3.8a.1 | W09C5.7a.1 | PI3K/PI4K domain-containing protein. | SAC domain-containing protein. | 0.901 |
| C56A3.8 | Y75B8A.24 | C56A3.8a.1 | Y75B8A.24.1 | PI3K/PI4K domain-containing protein. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.990 |
| C56A3.8 | ZC8.6 | C56A3.8a.1 | ZC8.6.1 | PI3K/PI4K domain-containing protein. | PI3K/PI4K domain-containing protein. | 0.922 |
| C56A3.8 | daf-18 | C56A3.8a.1 | T07A9.6.1 | PI3K/PI4K domain-containing protein. | Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly, [...] | 0.906 |
| C56A3.8 | egl-8 | C56A3.8a.1 | B0348.4d.1 | PI3K/PI4K domain-containing protein. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] | 0.900 |
| C56A3.8 | inpp-1 | C56A3.8a.1 | T25B9.10b.1 | PI3K/PI4K domain-containing protein. | IPPc domain-containing protein. | 0.910 |
| C56A3.8 | mtm-1 | C56A3.8a.1 | Y110A7A.5.1 | PI3K/PI4K domain-containing protein. | Myotubularin-related protein 1; Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles. Negatively regulates phagocytosis of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex. In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane. Essential for embryonic and larval development. May promote migration of distal tip cells ; B [...] | 0.902 |
| C56A3.8 | mtm-3 | C56A3.8a.1 | T24A11.1a.1 | PI3K/PI4K domain-containing protein. | Myotubularin-related protein 3; Preferentially dephosphorylates phosphatidylinositol 3- phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation. Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination. | 0.903 |
| C56A3.8 | mtm-6 | C56A3.8a.1 | F53A2.8b.2 | PI3K/PI4K domain-containing protein. | Myotubularin-related protein 6; May dephosphorylate phosphatidylinositol-3-phosphate (PI3P). In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels. Regulates fluid phase endocytosis in coelomocytes. Controls the endosomal localization of sorting nexin snx-3 and the levels of sorting receptor mig-14. By regulating the retrograde transport of mig-14, may be involved in the secretion of Wnt ligands such as egl-20. Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast d [...] | 0.908 |
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