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pdhb-1 pdhb-1 icl-1 icl-1 dlat-2 dlat-2 acs-19 acs-19 pyc-1 pyc-1 alh-9 alh-9 ldh-1 ldh-1 mdh-2 mdh-2 dlat-1 dlat-1 pyk-1 pyk-1 F32D8.12 F32D8.12 alh-11 alh-11 mdh-1 mdh-1 alh-1 alh-1 fum-1 fum-1 alh-2 alh-2 dld-1 dld-1 pck-2 pck-2 T02G5.7 T02G5.7 kat-1 kat-1 pdha-1 pdha-1 alh-4 alh-4 alh-5 alh-5 pck-1 pck-1 pod-2 pod-2 Y17G7B.3 Y17G7B.3 men-1 men-1 alh-12 alh-12 pyk-2 pyk-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pdhb-1Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (352 aa)
icl-1Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family. (968 aa)
dlat-22-oxoacid_dh domain-containing protein. (337 aa)
acs-19Acetyl-coenzyme A synthetase. (680 aa)
pyc-1Pyruvate carboxylase 1; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1175 aa)
alh-9Putative aldehyde dehydrogenase family 7 member A1 homolog; Belongs to the aldehyde dehydrogenase family. (531 aa)
ldh-1L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. LDH family. (336 aa)
mdh-2Probable malate dehydrogenase, mitochondrial. (341 aa)
dlat-1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (507 aa)
pyk-1Pyruvate kinase; Belongs to the pyruvate kinase family. (913 aa)
F32D8.12FAD-binding PCMH-type domain-containing protein. (474 aa)
alh-11Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (687 aa)
mdh-1Malate dehydrogenase. (336 aa)
alh-1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (510 aa)
fum-1Probable fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (501 aa)
alh-2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (514 aa)
dld-1Dihydrolipoyl dehydrogenase, mitochondrial. (495 aa)
pck-2Phosphoenolypyruvate CarboxyKinase. (654 aa)
T02G5.7Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
kat-1Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
pdha-1Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (414 aa)
alh-4Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
alh-5Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (437 aa)
pck-1PEPCK_GTP domain-containing protein. (651 aa)
pod-2Uncharacterized protein. (2165 aa)
Y17G7B.3Lactamase_B domain-containing protein. (260 aa)
men-1Malic enzyme. (620 aa)
alh-12Aldedh domain-containing protein. (499 aa)
pyk-2Pyruvate kinase; Belongs to the pyruvate kinase family. (515 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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