STRINGSTRING
mel-32 mel-32 C05D11.5 C05D11.5 icl-1 icl-1 C13B9.2 C13B9.2 gln-6 gln-6 acs-19 acs-19 gln-1 gln-1 C45E5.1 C45E5.1 C53A3.2 C53A3.2 gcsh-1 gcsh-1 afmd-1 afmd-1 mce-1 mce-1 mdh-2 mdh-2 gcst-1 gcst-1 gln-5 gln-5 pcca-1 pcca-1 F41E6.5 F41E6.5 F44E7.2 F44E7.2 mdh-1 mdh-1 gcsh-2 gcsh-2 pccb-1 pccb-1 aco-2 aco-2 gln-2 gln-2 K09H11.7 K09H11.7 dld-1 dld-1 gldc-1 gldc-1 T02G5.7 T02G5.7 kat-1 kat-1 agxt-1 agxt-1 cts-1 cts-1 gln-3 gln-3 ctl-3 ctl-3 ctl-2 ctl-2 ctl-1 ctl-1 mmcm-1 mmcm-1 aco-1 aco-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mel-32Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. (507 aa)
C05D11.5Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. (262 aa)
icl-1Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family. (968 aa)
C13B9.2Uncharacterized protein C13B9.2; Belongs to the glycerate kinase type-2 family. (458 aa)
gln-6Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (368 aa)
acs-19Acetyl-coenzyme A synthetase. (680 aa)
gln-1Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (385 aa)
C45E5.1Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily. (303 aa)
C53A3.2PhosphoGlycolate Phosphatase Homolog. (349 aa)
gcsh-1Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (148 aa)
afmd-1Abhydrolase_3 domain-containing protein. (271 aa)
mce-1Mitochondrial methylmalonyl-CoA epimerase. (162 aa)
mdh-2Probable malate dehydrogenase, mitochondrial. (341 aa)
gcst-1Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (402 aa)
gln-5Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (369 aa)
pcca-1Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...] (724 aa)
F41E6.5FMN hydroxy acid dehydrogenase domain-containing protein. (371 aa)
F44E7.2PhosphoGlycolate Phosphatase Homolog. (335 aa)
mdh-1Malate dehydrogenase. (336 aa)
gcsh-2Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (146 aa)
pccb-1Propionyl Coenzyme A Carboxylase Beta subunit. (536 aa)
aco-2Probable aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (777 aa)
gln-2Probable glutamine synthetase. (367 aa)
K09H11.7PhosphoGlycolate Phosphatase Homolog; Belongs to the HAD-like hydrolase superfamily. (322 aa)
dld-1Dihydrolipoyl dehydrogenase, mitochondrial. (495 aa)
gldc-1Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (979 aa)
T02G5.7Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
kat-1Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
agxt-1Serine--pyruvate aminotransferase. (405 aa)
cts-1Probable citrate synthase, mitochondrial. (468 aa)
gln-3Glutamine synthetase. (388 aa)
ctl-3Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (512 aa)
ctl-2Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. (500 aa)
ctl-1Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. (497 aa)
mmcm-1Probable methylmalonyl-CoA mutase, mitochondrial; Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (By similarity). (744 aa)
aco-1Probable cytoplasmic aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (887 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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