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sucl-1 sucl-1 ech-1.1 ech-1.1 C32E8.9 C32E8.9 acs-19 acs-19 acox-1.5 acox-1.5 sucg-1 sucg-1 mce-1 mce-1 acox-1.1 acox-1.1 acox-1.2 acox-1.2 acox-1.3 acox-1.3 acox-1.4 acox-1.4 hach-1 hach-1 ldh-1 ldh-1 alh-8 alh-8 sucl-2 sucl-2 bckd-1B bckd-1B pcca-1 pcca-1 mlcd-1 mlcd-1 suca-1 suca-1 pccb-1 pccb-1 acox-3 acox-3 acox-1.6 acox-1.6 gta-1 gta-1 dld-1 dld-1 T02G5.7 T02G5.7 kat-1 kat-1 ech-6 ech-6 ech-1.2 ech-1.2 pod-2 pod-2 ech-7 ech-7 bckd-1A bckd-1A mmcm-1 mmcm-1 dbt-1 dbt-1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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gene fusions
gene co-occurrence
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textmining
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sucl-1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (322 aa)
ech-1.1Enoyl-CoA Hydratase. (755 aa)
C32E8.9Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (268 aa)
acs-19Acetyl-coenzyme A synthetase. (680 aa)
acox-1.5Probable peroxisomal acyl-coenzyme A oxidase 1.5; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (659 aa)
sucg-1Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (415 aa)
mce-1Mitochondrial methylmalonyl-CoA epimerase. (162 aa)
acox-1.1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (674 aa)
acox-1.2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
acox-1.3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
acox-1.4Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa)
hach-13-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
ldh-1L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. LDH family. (336 aa)
alh-8Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity); Belongs to the aldehyde dehydrogenase family. (523 aa)
sucl-2Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (321 aa)
bckd-1BTransket_pyr domain-containing protein. (366 aa)
pcca-1Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...] (724 aa)
mlcd-1MaLonyl CoA Decarboxylase. (442 aa)
suca-1Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (435 aa)
pccb-1Propionyl Coenzyme A Carboxylase Beta subunit. (536 aa)
acox-3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
acox-1.6Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
gta-1Probable 4-aminobutyrate aminotransferase, mitochondrial. (483 aa)
dld-1Dihydrolipoyl dehydrogenase, mitochondrial. (495 aa)
T02G5.7Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
kat-1Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
ech-6Probable enoyl-CoA hydratase, mitochondrial. (288 aa)
ech-1.2Enoyl-CoA Hydratase. (781 aa)
pod-2Uncharacterized protein. (2165 aa)
ech-7Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa)
bckd-1A2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required for the production of the monomethyl branched-chain fatty acids (mmBCFAs) isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). (432 aa)
mmcm-1Probable methylmalonyl-CoA mutase, mitochondrial; Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (By similarity). (744 aa)
dbt-12-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2) (By similarity). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxyl [...] (448 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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