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| | gspd-1 | Glucose-6-phosphate 1-dehydrogenase; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes. (522 aa) |
| | rpia-1 | Probable-ribose 5-phosphate isomerase; Belongs to the ribose 5-phosphate isomerase family. (251 aa) |
| | sdha-1 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (646 aa) |
| | pdhb-1 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (352 aa) |
| | mel-32 | Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. (507 aa) |
| | icl-1 | Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family. (968 aa) |
| | sucl-1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (322 aa) |
| | mthf-1 | Probable methylenetetrahydrofolate reductase. (663 aa) |
| | C13B9.2 | Uncharacterized protein C13B9.2; Belongs to the glycerate kinase type-2 family. (458 aa) |
| | got-2.2 | Aspartate aminotransferase. (414 aa) |
| | cysl-1 | Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. (341 aa) |
| | ech-1.1 | Enoyl-CoA Hydratase. (755 aa) |
| | idhg-2 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (373 aa) |
| | dlat-2 | 2-oxoacid_dh domain-containing protein. (337 aa) |
| | C31C9.2 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa) |
| | C32F10.8 | Aminotran_1_2 domain-containing protein. (504 aa) |
| | sdha-2 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (640 aa) |
| | idh-2 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (435 aa) |
| | acs-19 | Acetyl-coenzyme A synthetase. (680 aa) |
| | idhb-1 | Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (379 aa) |
| | got-2.1 | Aspartate aminotransferase. (419 aa) |
| | C45E5.1 | Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily. (303 aa) |
| | acox-1.5 | Probable peroxisomal acyl-coenzyme A oxidase 1.5; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (659 aa) |
| | C50D2.7 | Probable ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6- phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity); Belongs to the ADP-dependent glucokinase family. (502 aa) |
| | pfk-1.2 | ATP-dependent 6-phosphofructokinase 2; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (756 aa) |
| | sucg-1 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (415 aa) |
| | C53A3.2 | PhosphoGlycolate Phosphatase Homolog. (349 aa) |
| | gcsh-1 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (148 aa) |
| | pyc-1 | Pyruvate carboxylase 1; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1175 aa) |
| | mce-1 | Mitochondrial methylmalonyl-CoA epimerase. (162 aa) |
| | aldo-2 | Fructose-bisphosphate aldolase 2. (366 aa) |
| | tkt-1 | Transket_pyr domain-containing protein. (618 aa) |
| | acox-1.1 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (674 aa) |
| | acox-1.2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa) |
| | acox-1.3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa) |
| | acox-1.4 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa) |
| | F08F8.7 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (227 aa) |
| | hach-1 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa) |
| | alh-8 | Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity); Belongs to the aldehyde dehydrogenase family. (523 aa) |
| | hxk-1 | Phosphotransferase; Belongs to the hexokinase family. (500 aa) |
| | mdh-2 | Probable malate dehydrogenase, mitochondrial. (341 aa) |
| | dlat-1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (507 aa) |
| | sucl-2 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (321 aa) |
| | gcst-1 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (402 aa) |
| | pyk-1 | Pyruvate kinase; Belongs to the pyruvate kinase family. (913 aa) |
| | F26D11.1 | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. (174 aa) |
| | F26H9.5 | Probable phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (370 aa) |
| | pcca-1 | Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...] (724 aa) |
| | sdhd-1 | Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (145 aa) |
| | gpd-4 | Glyceraldehyde-3-phosphate dehydrogenase 4. (341 aa) |
| | idhg-1 | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (396 aa) |
| | F41E6.5 | FMN hydroxy acid dehydrogenase domain-containing protein. (371 aa) |
| | sdhb-1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (298 aa) |
| | idha-1 | Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (358 aa) |
| | F44E7.2 | PhosphoGlycolate Phosphatase Homolog. (335 aa) |
| | mdh-1 | Malate dehydrogenase. (336 aa) |
| | suca-1 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (435 aa) |
| | gcsh-2 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (146 aa) |
| | pccb-1 | Propionyl Coenzyme A Carboxylase Beta subunit. (536 aa) |
| | aco-2 | Probable aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (777 aa) |
| | ipgm-1 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (539 aa) |
| | acox-3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa) |
| | cysl-4 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa) |
| | idh-1 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (435 aa) |
| | acox-1.6 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa) |
| | fum-1 | Probable fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (501 aa) |
| | H24K24.3 | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (By similarity). Plays a role in the calcium flux to the cytoplasm in the ASJ sensory neurons upon removal of a nitric oxide stimulus. (386 aa) |
| | K01C8.1 | ACT domain-containing protein. (499 aa) |
| | fbp-1 | FBPase domain-containing protein; Belongs to the FBPase class 1 family. (341 aa) |
| | K09H11.7 | PhosphoGlycolate Phosphatase Homolog; Belongs to the HAD-like hydrolase superfamily. (322 aa) |
| | gpd-3 | Glyceraldehyde-3-phosphate dehydrogenase 3. (341 aa) |
| | gpd-2 | Glyceraldehyde-3-phosphate dehydrogenase 2. (341 aa) |
| | cysl-2 | Bifunctional L-3-cyanoalanine synthase/cysteine synthase; Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide. Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from either S-sulfocysteine or O- acetylserine and hydrogen sulfide. By catalyzing the assimilation of cyanide produced by P.aeruginosa, mediates resistance to infection. Involved in fertility, growth and aging. Does not mediate surv [...] (337 aa) |
| | dld-1 | Dihydrolipoyl dehydrogenase, mitochondrial. (495 aa) |
| | cysl-3 | Cysteine synthase 3; Primarily catalyzes the formation of cysteine and acetate from O-acetylserine and hydrogen sulfide. Can also catalyze the formation of cysteine and acetate from S-sulfocysteine and hydrogen sulfide and the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide. Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa) |
| | gldc-1 | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (979 aa) |
| | R151.2 | Pribosyltran_N domain-containing protein. (446 aa) |
| | got-1.2 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system. (408 aa) |
| | T02G5.7 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa) |
| | kat-1 | Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family. (407 aa) |
| | pgk-1 | Probable phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (417 aa) |
| | aldo-1 | Fructose-bisphosphate aldolase 1. (365 aa) |
| | ech-6 | Probable enoyl-CoA hydratase, mitochondrial. (288 aa) |
| | pdha-1 | Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (414 aa) |
| | mev-1 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). Mediates resistance to enteropathogenic E.coli infection. Belongs to the cytochrome b560 family. (182 aa) |
| | ech-1.2 | Enoyl-CoA Hydratase. (781 aa) |
| | gpd-1 | Glyceraldehyde-3-phosphate dehydrogenase 1. (341 aa) |
| | agxt-1 | Serine--pyruvate aminotransferase. (405 aa) |
| | cts-1 | Probable citrate synthase, mitochondrial. (468 aa) |
| | enol-1 | Enolase; Belongs to the enolase family. (465 aa) |
| | ogdh-1 | 2-oxoglutarate dehydrogenase, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (1029 aa) |
| | T25B9.9 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa) |
| | dlst-1 | Lipoyl-binding domain-containing protein. (463 aa) |
| | W02H5.8 | Uncharacterized protein. (578 aa) |
| | ech-7 | Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa) |
| | tpi-1 | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (247 aa) |
| | tald-1 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (319 aa) |
| | men-1 | Malic enzyme. (620 aa) |
| | Y48G10A.1 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (280 aa) |
| | Y51H7C.9 | ACT domain-containing protein. (448 aa) |
| | ctl-3 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (512 aa) |
| | ctl-2 | Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. (500 aa) |
| | ctl-1 | Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. (497 aa) |
| | Y57G11C.3 | Putative 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. (269 aa) |
| | Y62E10A.13 | Uncharacterized protein. (287 aa) |
| | pfk-1.1 | ATP-dependent 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (814 aa) |
| | gpi-1 | Glucose-6-phosphate isomerase; Belongs to the GPI family. (586 aa) |
| | mmcm-1 | Probable methylmalonyl-CoA mutase, mitochondrial; Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (By similarity). (744 aa) |
| | aco-1 | Probable cytoplasmic aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (887 aa) |
| | pyk-2 | Pyruvate kinase; Belongs to the pyruvate kinase family. (515 aa) |
| | gdh-1 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (536 aa) |
