(19 nodes) 2-Oxocarboxylic acid metabolism network (Caenorhabditis elegans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C06A6.4	M20_dimer domain-containing protein. (411 aa)
	C10C5.3	M20_dimer domain-containing protein. (399 aa)
	C10C5.4	M20_dimer domain-containing protein. (397 aa)
	C10C5.5	M20_dimer domain-containing protein. (397 aa)
	got-2.2	Aspartate aminotransferase. (414 aa)
	idhg-2	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (373 aa)
	C32F10.8	Aminotran_1_2 domain-containing protein. (504 aa)
	idh-2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (435 aa)
	idhb-1	Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (379 aa)
	got-2.1	Aspartate aminotransferase. (419 aa)
	idhg-1	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (396 aa)
	idha-1	Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (358 aa)
	aco-2	Probable aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (777 aa)
	idh-1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (435 aa)
	bcat-1	Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (415 aa)
	got-1.2	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system. (408 aa)
	cts-1	Probable citrate synthase, mitochondrial. (468 aa)
	Y44A6D.5	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (393 aa)
	aco-1	Probable cytoplasmic aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (887 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C06A6.4	C32F10.8	C06A6.4b.2	C32F10.8a.4	M20_dimer domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.483
C10C5.3	C10C5.4	C10C5.3.1	C10C5.4.1	M20_dimer domain-containing protein.	M20_dimer domain-containing protein.	0.555
C10C5.3	C10C5.5	C10C5.3.1	C10C5.5.1	M20_dimer domain-containing protein.	M20_dimer domain-containing protein.	0.568
C10C5.3	C32F10.8	C10C5.3.1	C32F10.8a.4	M20_dimer domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.466
C10C5.4	C10C5.3	C10C5.4.1	C10C5.3.1	M20_dimer domain-containing protein.	M20_dimer domain-containing protein.	0.555
C10C5.4	C10C5.5	C10C5.4.1	C10C5.5.1	M20_dimer domain-containing protein.	M20_dimer domain-containing protein.	0.413
C10C5.4	C32F10.8	C10C5.4.1	C32F10.8a.4	M20_dimer domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.466
C10C5.5	C10C5.3	C10C5.5.1	C10C5.3.1	M20_dimer domain-containing protein.	M20_dimer domain-containing protein.	0.568
C10C5.5	C10C5.4	C10C5.5.1	C10C5.4.1	M20_dimer domain-containing protein.	M20_dimer domain-containing protein.	0.413
C10C5.5	C32F10.8	C10C5.5.1	C32F10.8a.4	M20_dimer domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.466
C32F10.8	C06A6.4	C32F10.8a.4	C06A6.4b.2	Aminotran_1_2 domain-containing protein.	M20_dimer domain-containing protein.	0.483
C32F10.8	C10C5.3	C32F10.8a.4	C10C5.3.1	Aminotran_1_2 domain-containing protein.	M20_dimer domain-containing protein.	0.466
C32F10.8	C10C5.4	C32F10.8a.4	C10C5.4.1	Aminotran_1_2 domain-containing protein.	M20_dimer domain-containing protein.	0.466
C32F10.8	C10C5.5	C32F10.8a.4	C10C5.5.1	Aminotran_1_2 domain-containing protein.	M20_dimer domain-containing protein.	0.466
C32F10.8	Y44A6D.5	C32F10.8a.4	Y44A6D.5.1	Aminotran_1_2 domain-containing protein.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.552
C32F10.8	aco-2	C32F10.8a.4	F54H12.1a.1	Aminotran_1_2 domain-containing protein.	Probable aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	0.575
C32F10.8	bcat-1	C32F10.8a.4	K02A4.1.1	Aminotran_1_2 domain-containing protein.	Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.567
C32F10.8	cts-1	C32F10.8a.4	T20G5.2.1	Aminotran_1_2 domain-containing protein.	Probable citrate synthase, mitochondrial.	0.541
C32F10.8	got-1.2	C32F10.8a.4	T01C8.5.1	Aminotran_1_2 domain-containing protein.	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system.	0.981
C32F10.8	got-2.1	C32F10.8a.4	C44E4.3.1	Aminotran_1_2 domain-containing protein.	Aspartate aminotransferase.	0.997