68 items (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	B0272.3	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (309 aa)
	B0303.3	Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. (448 aa)
	stdh-1	Putative steroid dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (314 aa)
	stdh-3	Putative steroid dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa)
	art-1	Probable very-long-chain enoyl-CoA reductase art-1; Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precurso [...] (308 aa)
	ech-1.1	Enoyl-CoA Hydratase. (755 aa)
	elo-4	Putative fatty acid elongation protein 4; Could be implicated in synthesis of very long chain fatty acids; Belongs to the ELO family. (291 aa)
	acs-17	Fatty Acid CoA Synthetase family. (718 aa)
	acox-1.5	Probable peroxisomal acyl-coenzyme A oxidase 1.5; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (659 aa)
	C50D2.9	PKS_AT domain-containing protein. (405 aa)
	acdh-1	Acyl CoA DeHydrogenase. (427 aa)
	let-767	Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (337 aa)
	elo-3	Putative fatty acid elongation protein 3; Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth. Belongs to the ELO family. (320 aa)
	maoc-1	MAO-C-like dehydratase domain. (298 aa)
	acdh-12	Acyl CoA DeHydrogenase. (613 aa)
	ech-8	Enoyl-CoA Hydratase. (437 aa)
	ech-9	Enoyl-CoA Hydratase. (434 aa)
	acox-1.1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (674 aa)
	acox-1.2	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
	acox-1.3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
	acox-1.4	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa)
	dhs-25	DeHydrogenases, Short chain. (248 aa)
	fat-7	Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
	F10G8.9	PKS_KS domain-containing protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (403 aa)
	stdh-2	Putative steroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa)
	elo-2	Elongation of very long chain fatty acids protein. (274 aa)
	stdh-4	Putative steroid dehydrogenase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (317 aa)
	acs-2	Fatty Acid CoA Synthetase family. (618 aa)
	fasn-1	Carrier domain-containing protein. (2613 aa)
	acs-4	Fatty Acid CoA Synthetase family. (731 aa)
	elo-5	Elongation of very long chain fatty acids protein 5; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). Belongs to the ELO family. (274 aa)
	elo-6	Elongation of very long chain fatty acids protein 6; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isoheptadecanoate (C17iso). (274 aa)
	ppt-1	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides. (298 aa)
	acs-16	AMP-binding domain-containing protein. (569 aa)
	acaa-2	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	F54C8.1	Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (298 aa)
	elo-1	Elongation of very long chain fatty acids protein. (288 aa)
	acox-3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
	acox-1.6	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
	acdh-8	Acyl CoA DeHydrogenase. (412 aa)
	acdh-3	Acyl CoA DeHydrogenase. (419 aa)
	dhs-28	SCP2 domain-containing protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (436 aa)
	acs-15	Fatty Acid CoA Synthetase family. (703 aa)
	cpt-2	Calponin-homology (CH) domain-containing protein. (646 aa)
	hacd-1	Hydroxy-Acyl-CoA Dehydrogenase. (299 aa)
	acs-18	AMP-binding domain-containing protein. (700 aa)
	T02G5.7	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
	kat-1	Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
	ech-6	Probable enoyl-CoA hydratase, mitochondrial. (288 aa)
	acs-3	AMP-binding domain-containing protein. (653 aa)
	ech-1.2	Enoyl-CoA Hydratase. (781 aa)
	acdh-10	Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family. (417 aa)
	acdh-4	Acyl CoA DeHydrogenase. (385 aa)
	hpo-8	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precu [...] (218 aa)
	acdh-7	Acyl CoA DeHydrogenase. (412 aa)
	fat-6	Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
	W03F9.4	Carn_acyltransf domain-containing protein. (746 aa)
	fat-5	Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
	pod-2	Uncharacterized protein. (2165 aa)
	mecr-1	Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (344 aa)
	ech-7	Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa)
	dhs-11	DeHydrogenases, Short chain. (244 aa)
	cpt-1	Carnitine Palmitoyl Transferase; Belongs to the carnitine/choline acetyltransferase family. (779 aa)
	Y48A6B.9	Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (346 aa)
	elo-9	Elongation of very long chain fatty acids protein. (286 aa)
	daf-22	Non-specific lipid-transfer protein-like 2; Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone. Belongs to the thiolase-like superfamily. Thiolase family. (412 aa)
	acs-13	AMP-binding domain-containing protein. (726 aa)
	acs-5	Fatty Acid CoA Synthetase family. (687 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0272.3	B0303.3	B0272.3.1	B0303.3.2	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family.	0.991
B0272.3	T02G5.7	B0272.3.1	T02G5.7.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.989
B0272.3	acaa-2	B0272.3.1	F53A2.7.2	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family.	0.991
B0272.3	acdh-1	B0272.3.1	C55B7.4a.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl CoA DeHydrogenase.	0.717
B0272.3	acdh-10	B0272.3.1	T08G2.3.2	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family.	0.867
B0272.3	acdh-12	B0272.3.1	E04F6.5a.2	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl CoA DeHydrogenase.	0.835
B0272.3	acdh-3	B0272.3.1	K06A5.6.2	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl CoA DeHydrogenase.	0.718
B0272.3	acdh-4	B0272.3.1	T10E9.9b.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl CoA DeHydrogenase.	0.710
B0272.3	acdh-7	B0272.3.1	T25G12.5.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl CoA DeHydrogenase.	0.825
B0272.3	acdh-8	B0272.3.1	K05F1.3.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl CoA DeHydrogenase.	0.724
B0272.3	acox-1.1	B0272.3.1	F08A8.1a.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.913
B0272.3	acox-1.2	B0272.3.1	F08A8.2.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.870
B0272.3	acox-1.3	B0272.3.1	F08A8.3.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.910
B0272.3	acox-1.4	B0272.3.1	F08A8.4.2	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.912
B0272.3	acox-1.5	B0272.3.1	C48B4.1.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Probable peroxisomal acyl-coenzyme A oxidase 1.5; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs.	0.912
B0272.3	acox-1.6	B0272.3.1	F59F4.1.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.868
B0272.3	acox-3	B0272.3.1	F58F9.7.3	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.917
B0272.3	acs-13	B0272.3.1	Y65B4BL.5c.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	AMP-binding domain-containing protein.	0.711
B0272.3	acs-15	B0272.3.1	R07C3.4.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Fatty Acid CoA Synthetase family.	0.711
B0272.3	acs-16	B0272.3.1	F47G6.2.1	Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	AMP-binding domain-containing protein.	0.853