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kin-3 kin-3 B0280.9 B0280.9 C05C8.5 C05C8.5 C05D11.9 C05D11.9 C08B6.8 C08B6.8 C15C6.4 C15C6.4 nxf-1 nxf-1 nxf-2 nxf-2 nola-3 nola-3 eif-6 eif-6 C48B6.2 C48B6.2 C53H9.2 C53H9.2 E02H1.6 E02H1.6 F13H8.2 F13H8.2 drsh-1 drsh-1 F27C1.6 F27C1.6 F30A10.9 F30A10.9 pqe-1 pqe-1 nath-10 nath-10 F55F10.1 F55F10.1 F55F8.3 F55F8.3 H35B03.2 H35B03.2 nst-1 nst-1 ran-1 ran-1 K01G5.5 K01G5.5 nol-56 nol-56 K10C3.5 K10C3.5 riok-1 riok-1 M28.5 M28.5 rbm-28 rbm-28 fib-1 fib-1 kin-10 kin-10 nog-1 nog-1 ngp-1 ngp-1 T25G3.3 T25G3.3 nol-58 nol-58 sbds-1 sbds-1 riok-2 riok-2 Y23H5B.5 Y23H5B.5 Y39A1A.14 Y39A1A.14 xrn-1 xrn-1 Y45F10D.7 Y45F10D.7 Y48A6B.3 Y48A6B.3 xrn-2 xrn-2 mac-1 mac-1 nol-6 nol-6 Y53C12B.1 Y53C12B.1 Y54E10BR.4 Y54E10BR.4 Y56A3A.33 Y56A3A.33 Y61A9LA.10 Y61A9LA.10 Y62E10A.24 Y62E10A.24 Y66A7A.2 Y66A7A.2 Y66H1A.4 Y66H1A.4 nxt-1 nxt-1 Y75B8A.7 Y75B8A.7 ZC434.4 ZC434.4 ZK1127.5 ZK1127.5 toe-1 toe-1 ZK632.14 ZK632.14 xpo-1 xpo-1 ZK795.3 ZK795.3
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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kin-3Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2. (360 aa)
B0280.9U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family. (429 aa)
C05C8.5Exonuclease domain-containing protein. (594 aa)
C05D11.9Uncharacterized protein C05D11.9. (752 aa)
C08B6.8Probable oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. (193 aa)
C15C6.4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (198 aa)
nxf-1Nuclear RNA export factor 1; Involved in RNA export from the nucleus to the cytoplasm; Belongs to the NXF family. (609 aa)
nxf-2Nuclear RNA export factor 2; May be involved in the export of cellular mRNA to the cytoplasm; Belongs to the NXF family. (405 aa)
nola-3Putative H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (64 aa)
eif-6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing. (246 aa)
C48B6.2Putative 40S ribosomal protein S4-like. (183 aa)
C53H9.2CP-type G domain-containing protein. (554 aa)
E02H1.6Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. (182 aa)
F13H8.2WD_REPEATS_REGION domain-containing protein. (929 aa)
drsh-1Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family. (1086 aa)
F27C1.6Uncharacterized protein. (647 aa)
F30A10.9PINc domain-containing protein. (196 aa)
pqe-1Putative RNA exonuclease pqe-1; Putative RNA exonuclease which protects neurons from the toxic effects of expanded poly-Q disease proteins. It is unknown whether this is via participation in the pathogenic mechanism underlying poly-Q-induced neurodegeneration or if it is by acting as a genetic modifier of the age of onset or progression of neurodegeneration. Regulates gene expression in neurons. (1647 aa)
nath-10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1043 aa)
F55F10.1VWFA domain-containing protein. (4362 aa)
F55F8.3Periodic tryptophan protein 2 homolog; Belongs to the WD repeat PWP2 family. (910 aa)
H35B03.2Uncharacterized protein. (387 aa)
nst-1Guanine nucleotide-binding protein-like 3 homolog; May play a role in regulating cellular proliferation in both germline and somatic tissues. (556 aa)
ran-1GTP-binding nuclear protein ran-1; Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. (215 aa)
K01G5.5Putative H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the pseudouridine synthase TruB family. (445 aa)
nol-56Nucleolar protein 56; Required for 60S ribosomal subunit synthesis. Belongs to the NOP5/NOP56 family. (486 aa)
K10C3.5Tr-type G domain-containing protein. (894 aa)
riok-1Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). Plays a role in oogenesis by regulating germ cell proliferation, progression through diplotene and diakinesis stages and oocyte maturation. Regulates germline development probably by regulating the phosphorylation of mpk- 1. Involved in larval development. ECO:0 [...] (506 aa)
M28.5NHP2-like protein 1 homolog; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity); Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
rbm-28RNA Binding Motif protein homolog. (608 aa)
fib-1rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (By similarity). Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl- L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein [...] (352 aa)
kin-10Casein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2; Belongs to the casein kinase 2 subunit beta family. (235 aa)
nog-1Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Has a role in regulating longevity, growth and brood size. May regulate fat storage via the insulin/IGF pathway. (681 aa)
ngp-1Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (651 aa)
T25G3.360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (513 aa)
nol-58Nop domain-containing protein. (487 aa)
sbds-1Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with K10C3.5b/EFL1, triggers the GTP-dependent release of ribosome maturation factors from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). (253 aa)
riok-2Serine/threonine-protein kinase RIO2; Required for larval development. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (529 aa)
Y23H5B.5WD_REPEATS_REGION domain-containing protein. (561 aa)
Y39A1A.14Ribosomal RNA small subunit methyltransferase nep-1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3- carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre- ribosomes; Belongs to the class IV-like SAM-binding methyltransferase superfami [...] (231 aa)
xrn-15'-3' exoribonuclease 1. (1591 aa)
Y45F10D.7Uncharacterized protein. (924 aa)
Y48A6B.3Putative H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (163 aa)
xrn-25'-3' exoribonuclease 2 homolog; Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle. (975 aa)
mac-1Protein mac-1; Probably together with ced-9, plays a modest role in preventing ced-4 and caspase ced-3-mediated apoptosis. Belongs to the AAA ATPase family. (813 aa)
nol-6Nucleolar protein 6. (1058 aa)
Y53C12B.1WD_REPEATS_REGION domain-containing protein. (793 aa)
Y54E10BR.4RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (364 aa)
Y56A3A.33Exonuclease domain-containing protein. (365 aa)
Y61A9LA.10Bms1-type G domain-containing protein. (1055 aa)
Y62E10A.24Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (130 aa)
Y66A7A.2Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (158 aa)
Y66H1A.4Probable H/ACA ribonucleoprotein complex subunit 1-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (244 aa)
nxt-1NTF2-related export protein; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). (137 aa)
Y75B8A.7U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (648 aa)
ZC434.4Ribosomal RNA-processing protein 7 homolog; Belongs to the RRP7 family. (270 aa)
ZK1127.5Probable RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity); Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily. (379 aa)
toe-1HEAT repeat-containing protein 1 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity); Belongs to the HEATR1/UTP10 family. (1650 aa)
ZK632.14Alba domain-containing protein. (206 aa)
xpo-1Importin N-terminal domain-containing protein. (1080 aa)
ZK795.3Brix domain-containing protein ZK795.3. (292 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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