STRINGSTRING
rnh-1.3 rnh-1.3 mcm-3 mcm-3 lig-1 lig-1 rfc-3 rfc-3 rfc-1 rfc-1 pole-2 pole-2 F10C2.4 F10C2.4 F12F6.7 F12F6.7 rpa-1 rpa-1 F21D5.6 F21D5.6 rfc-4 rfc-4 mcm-7 mcm-7 pole-1 pole-1 dna-2 dna-2 F44B9.8 F44B9.8 pri-1 pri-1 rfc-2 rfc-2 rpa-4 rpa-4 rpa-2 rpa-2 div-1 div-1 R04F11.3 R04F11.3 mcm-5 mcm-5 rnh-2 rnh-2 T24C4.5 T24C4.5 T26A5.8 T26A5.8 pri-2 pri-2 pcn-1 pcn-1 mcm-2 mcm-2 mcm-4 mcm-4 pola-1 pola-1 crn-1 crn-1 Y53F4B.3 Y53F4B.3 ZK1127.13 ZK1127.13 mcm-6 mcm-6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rnh-1.3RNase H domain-containing protein. (139 aa)
mcm-3MCM domain-containing protein; Belongs to the MCM family. (812 aa)
lig-1DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (773 aa)
rfc-3RFC (DNA replication factor) family. (354 aa)
rfc-1Replication factor C subunit 1. (839 aa)
pole-2Probable DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (521 aa)
F10C2.4DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). (1081 aa)
F12F6.7Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. (451 aa)
rpa-1Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa)
F21D5.6RNase_H2-Ydr279 domain-containing protein. (290 aa)
rfc-4Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity). (334 aa)
mcm-7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (730 aa)
pole-1DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2144 aa)
dna-2Yeast DNA helicase/endonuclease family. (1069 aa)
F44B9.8Probable replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. (368 aa)
pri-1DNA primase small subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (410 aa)
rfc-2AAA domain-containing protein. (334 aa)
rpa-4RPA_C domain-containing protein. (293 aa)
rpa-2RPA_C domain-containing protein. (288 aa)
div-1DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. Required for the distribution of pie-1 in cell divsion. (581 aa)
R04F11.3Uncharacterized protein. (385 aa)
mcm-5DNA replication licensing factor mcm-5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (759 aa)
rnh-2Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). (297 aa)
T24C4.5DNA primase; Belongs to the eukaryotic-type primase small subunit family. (318 aa)
T26A5.8CBFD_NFYB_HMF domain-containing protein. (137 aa)
pri-2DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (503 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
mcm-2DNA helicase; Belongs to the MCM family. (881 aa)
mcm-4DNA replication licensing factor mcm-4; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (823 aa)
pola-1DNA polymerase. (1456 aa)
crn-1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
Y53F4B.3CBFD_NFYB_HMF domain-containing protein. (179 aa)
ZK1127.13Uncharacterized protein. (128 aa)
mcm-6DNA replication licensing factor mcm-6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (810 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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