node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F10C2.4 | F12F6.7 | F10C2.4.1 | F12F6.7.2 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. | 0.999 |
F10C2.4 | R04F11.3 | F10C2.4.1 | R04F11.3.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Uncharacterized protein. | 0.909 |
F10C2.4 | T26A5.8 | F10C2.4.1 | T26A5.8.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | CBFD_NFYB_HMF domain-containing protein. | 0.923 |
F10C2.4 | Y53F4B.3 | F10C2.4.1 | Y53F4B.3.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | CBFD_NFYB_HMF domain-containing protein. | 0.863 |
F10C2.4 | apn-1 | F10C2.4.1 | T05H10.2.2 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | DNA-(apurinic or apyrimidinic site) lyase. | 0.453 |
F10C2.4 | crn-1 | F10C2.4.1 | Y47G6A.8.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.995 |
F10C2.4 | exo-3 | F10C2.4.1 | R09B3.1a.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. | 0.691 |
F10C2.4 | lig-1 | F10C2.4.1 | C29A12.3a.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.955 |
F10C2.4 | nth-1 | F10C2.4.1 | R10E4.5d.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.621 |
F10C2.4 | pcn-1 | F10C2.4.1 | W03D2.4.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.997 |
F10C2.4 | pole-1 | F10C2.4.1 | F33H2.5.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.976 |
F10C2.4 | pole-2 | F10C2.4.1 | F08B4.5.1 | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | Probable DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.965 |
F12F6.7 | F10C2.4 | F12F6.7.2 | F10C2.4.1 | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. | DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). | 0.999 |
F12F6.7 | R04F11.3 | F12F6.7.2 | R04F11.3.1 | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. | Uncharacterized protein. | 0.908 |
F12F6.7 | T26A5.8 | F12F6.7.2 | T26A5.8.1 | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. | CBFD_NFYB_HMF domain-containing protein. | 0.940 |
F12F6.7 | Y53F4B.3 | F12F6.7.2 | Y53F4B.3.1 | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. | CBFD_NFYB_HMF domain-containing protein. | 0.859 |
F12F6.7 | apn-1 | F12F6.7.2 | T05H10.2.2 | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. | DNA-(apurinic or apyrimidinic site) lyase. | 0.435 |
F12F6.7 | crn-1 | F12F6.7.2 | Y47G6A.8.1 | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.959 |
F12F6.7 | exo-3 | F12F6.7.2 | R09B3.1a.1 | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. | DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. | 0.762 |
F12F6.7 | lig-1 | F12F6.7.2 | C29A12.3a.1 | Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. | DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.801 |