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egl-8 egl-8 B0563.7 B0563.7 tax-6 tax-6 ser-7 ser-7 orai-1 orai-1 cal-1 cal-1 C14B9.8 C14B9.8 cal-2 cal-2 trhr-1 trhr-1 sphk-1 sphk-1 lfe-2 lfe-2 C47E12.2 C47E12.2 egl-19 egl-19 tkr-2 tkr-2 cca-1 cca-1 nmr-1 nmr-1 acy-1 acy-1 F25B4.7 F25B4.7 plc-1 plc-1 itr-1 itr-1 csq-1 csq-1 cal-7 cal-7 mgl-2 mgl-2 gar-2 gar-2 cnb-1 cnb-1 ser-1 ser-1 ant-1.3 ant-1.3 mcu-1 mcu-1 K03A1.4 K03A1.4 cmk-1 cmk-1 K09A9.6 K09A9.6 unc-68 unc-68 sca-1 sca-1 unc-43 unc-43 egl-30 egl-30 cal-3 cal-3 mca-2 mca-2 vdac-1 vdac-1 plc-4 plc-4 gsa-1 gsa-1 R07E3.4 R07E3.4 cup-5 cup-5 ant-1.4 ant-1.4 plc-3 plc-3 pde-1 pde-1 cal-4 cal-4 cmd-1 cmd-1 T22F3.12 T22F3.12 ckr-1 ckr-1 ant-1.1 ant-1.1 ant-1.2 ant-1.2 mca-1 mca-1 ncx-1 ncx-1 gar-3 gar-3 Y50D7A.3 Y50D7A.3 stim-1 stim-1 Y67D8A.2 Y67D8A.2 mca-3 mca-3 mlck-1 mlck-1 let-23 let-23 kin-1 kin-1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
egl-81-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] (1512 aa)
B0563.7Uncharacterized calcium-binding protein B0563.7. (229 aa)
tax-6Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] (545 aa)
ser-7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (435 aa)
orai-1Protein orai; Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function. Belongs to the Orai family. (297 aa)
cal-1Calmodulin-like protein; This protein resembles calmodulin in sequence but possibly resembles troponin C in function. (180 aa)
C14B9.8Probable phosphorylase b kinase regulatory subunit alpha; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (By similarity). (1232 aa)
cal-2CALmodulin related genes. (171 aa)
trhr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (395 aa)
sphk-1Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). (473 aa)
lfe-2Inositol-trisphosphate 3-kinase homolog; Probably by regulating inositol 1,4,5-trisphosphate levels, negatively regulates posterior body wall muscle contractions required for defecation and let-23 signaling pathway that controls spermathecal dilation and ovulation. May also regulate ovulation downstream of actin cross-linker fln-1. (494 aa)
C47E12.2Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (306 aa)
egl-19Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1877 aa)
tkr-2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa)
cca-1Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1885 aa)
nmr-1NMDA-type ionotropic glutamate receptor NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1025 aa)
acy-1Adenylyl CYclase. (1253 aa)
F25B4.7Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (306 aa)
plc-11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. plc-1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity (By similarity). By activating IP3 receptor itr-1-mediated intracellular Ca(2+) release via the production of IP3, regulates ovulation by controlling contraction and/or dilation of the di [...] (1898 aa)
itr-1Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa)
csq-1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (417 aa)
cal-7EF-hand domain-containing protein. (179 aa)
mgl-2G_PROTEIN_RECEP_F3_4 domain-containing protein. (1035 aa)
gar-2Muscarinic acetylcholine receptor gar-2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o) alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholin [...] (667 aa)
cnb-1Protein phosphatase 2B regulatory subunit cnb-1; Regulatory subunit of tax-6/calcineurin A, a calcium- dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg- laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Negatively regulates lifespan. Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle [...] (171 aa)
ser-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (683 aa)
ant-1.3Mitochondrial adenine nucleotide translocase 1.3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
mcu-1Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Required for rapid mitochondrial calcium uptake and mitochondrial reactive oxygen species (mtROS) production after wounding. (333 aa)
K03A1.4EF-hand domain-containing protein. (184 aa)
cmk-1Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade which results in transcriptional activation. Transcriptional activation occurs at least in part through phosphorylation of crh-1. Regulates gene expression, sensory morphology, and function of the AFD thermosensory neurons. Involved in long-term adaptation of AFD neurons to temperatures warmer than the initial acclimatized cultivation temperature. Acts in the FLP thermal nociceptors to moderate the responsiveness to noxious [...] (348 aa)
K09A9.6TPR_REGION domain-containing protein. (920 aa)
unc-68Uncharacterized protein. (5202 aa)
sca-1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa)
unc-43Calcium/calmodulin-dependent protein kinase type II; Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the [...] (681 aa)
egl-30Heterotrimeric G protein alpha subunit. (355 aa)
cal-3CALmodulin related genes. (234 aa)
mca-2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1158 aa)
vdac-1Probable voltage-dependent anion-selective channel; Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. (283 aa)
plc-4Phosphoinositide phospholipase C. (751 aa)
gsa-1G protein, Subunit Alpha. (378 aa)
R07E3.4Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
cup-5PKD_channel domain-containing protein. (668 aa)
ant-1.4Mitochondrial adenine nucleotide translocase 1.4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
plc-31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca(2+) oscillations via IP3-mediated activation of IP3 receptor itr-1. In intestinal epithelial cells, regulates Ca(2+) oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation [...] (1350 aa)
pde-1Probable 3',5'-cyclic phosphodiesterase pde-1; Redundantly with pde-5, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels. (664 aa)
cal-4CALmodulin related genes. (236 aa)
cmd-1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
T22F3.12Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (174 aa)
ckr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (421 aa)
ant-1.1Adenine Nucleotide Translocator; Belongs to the mitochondrial carrier (TC 2.A.29) family. (300 aa)
ant-1.2Adenine Nucleotide Translocator; Belongs to the mitochondrial carrier (TC 2.A.29) family. (300 aa)
mca-1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1252 aa)
ncx-1Sodium-calcium exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (880 aa)
gar-3Muscarinic acetylcholine receptor gar-3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion. (611 aa)
Y50D7A.3Protein kinase domain-containing protein. (485 aa)
stim-1Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemostasis. (530 aa)
Y67D8A.2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1238 aa)
mca-3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1234 aa)
mlck-1Protein kinase domain-containing protein. (1211 aa)
let-23Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] (1335 aa)
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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