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| | dnj-1 | DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily. (401 aa) |
| | pdi-6 | Protein disulfide-isomerase A6 homolog; May function as a chaperone that inhibits aggregation of misfolded proteins (By similarity). May negatively regulate the unfolded protein response (UPR) through binding to UPR sensors ; Belongs to the protein disulfide isomerase family. (440 aa) |
| | jnk-1 | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] (463 aa) |
| | ufd-3 | Ubiquitin fusion degradation protein 3 homolog; Plays a role in protein ubiquitination, sorting and degradation through its association with cdc-48.1 and/or cdc-48.2. (860 aa) |
| | cdc-48.1 | Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] (809 aa) |
| | skr-17 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa) |
| | pdi-2 | Protein disulfide-isomerase 2; Involved in cuticle formation. May play a role in the unfolded protein response. Belongs to the protein disulfide isomerase family. (493 aa) |
| | hsp-70 | Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa) |
| | pdi-1 | Protein disulfide-isomerase 1; Belongs to the protein disulfide isomerase family. (485 aa) |
| | C14B9.2 | Probable protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. (618 aa) |
| | hsp-3 | Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa) |
| | C18E9.2 | Uncharacterized protein. (364 aa) |
| | tram-1 | Translocating chain-associated membrane protein; Belongs to the TRAM family. (373 aa) |
| | hsp-110 | Heat shock protein 110. (776 aa) |
| | ire-1 | Serine/threonine-protein kinase/endoribonuclease ire-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 upon ER str [...] (967 aa) |
| | cdc-48.2 | Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] (810 aa) |
| | skr-16 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa) |
| | C47E12.3 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (568 aa) |
| | hsp-90 | Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa) |
| | skr-12 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) |
| | skr-9 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | skr-13 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) |
| | skr-8 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | mans-2 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase C52E4.5; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (By similarity). (590 aa) |
| | dnj-7 | DNaJ domain (Prokaryotic heat shock protein). (491 aa) |
| | ubc-6 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (314 aa) |
| | mans-1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (540 aa) |
| | cul-1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa) |
| | F10C2.5 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (781 aa) |
| | F11F1.1 | DUF148 domain-containing protein; Belongs to the heat shock protein 70 family. (607 aa) |
| | sec-24.1 | Yeast SEC homolog. (1126 aa) |
| | mogs-1 | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically. (796 aa) |
| | ubql-1 | Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] (502 aa) |
| | ufd-1 | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway (By similarity). In association with npl-4.1 and/or npl-4.2 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with npl-4.1 and/or npl-4.2, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradati [...] (342 aa) |
| | ubxn-1 | UBX domain-containing protein 1; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. (299 aa) |
| | cup-2 | Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. (245 aa) |
| | hsp-1 | Heat shock 70 kDa protein A. (640 aa) |
| | hrdl-1 | E3 ubiquitin-protein ligase hrd-like protein 1; Proposed to have a role in neuroprotection. (579 aa) |
| | atx-3 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...] (317 aa) |
| | emo-1 | Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family. (68 aa) |
| | dnj-12 | DNaJ domain (Prokaryotic heat shock protein). (402 aa) |
| | aagr-3 | DUF5110 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (924 aa) |
| | hsp-4 | Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family. (657 aa) |
| | F44E5.4 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (645 aa) |
| | skr-3 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa) |
| | sel-1 | Suppressor/Enhancer of Lin-12. (685 aa) |
| | atf-6 | BZIP domain-containing protein. (589 aa) |
| | skr-2 | SKp1 Related (Ubiquitin ligase complex component). (174 aa) |
| | skr-1 | Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa) |
| | pek-1 | Eukaryotic translation initiation factor 2-alpha kinase pek-1; Phosphorylates the alpha subunit of eukaryotic translation- initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. May phosphorylate eIF2alpha during hypoxia. Proposed to have a role in alleviating endoplasmic reticulum stress ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1077 aa) |
| | skr-5 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa) |
| | uggt-1 | UDP-Glucose Glycoprotein glucosylTransferase. (1493 aa) |
| | aagr-4 | Gal_mutarotas_2 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (903 aa) |
| | skr-15 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa) |
| | F54F2.9 | Uncharacterized protein F54F2.9. (414 aa) |
| | sel-11 | E3 ubiquitin-protein ligase hrd-1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play [...] (610 aa) |
| | marc-6 | RING-CH-type domain-containing protein. (1025 aa) |
| | skr-18 | Skp1 domain-containing protein; Belongs to the SKP1 family. (183 aa) |
| | png-1 | Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta- aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native protein [...] (606 aa) |
| | dad-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across th [...] (113 aa) |
| | bag-1 | BAG family molecular chaperone regulator 1; May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner. (210 aa) |
| | ubc-7 | Probable ubiquitin-conjugating enzyme E2 7; Catalyzes the covalent attachment of ubiquitin to other proteins. (164 aa) |
| | nsy-1 | Mitogen-activated protein kinase kinase kinase nsy-1; Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacteri [...] (1498 aa) |
| | npl-4.1 | Nuclear protein localization protein 4 homolog 1; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] (529 aa) |
| | npl-4.2 | Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...] (529 aa) |
| | ubxn-6 | UBX domain-containing protein 6; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. Involved in the lysosomal clearance of cellular material in diet restricted conditions. (437 aa) |
| | pdi-3 | Protein disulfide-isomerase. (488 aa) |
| | unc-23 | BAG domain-containing protein. (458 aa) |
| | sec-12 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | dnj-14 | J domain-containing protein. (217 aa) |
| | cdc-48.3 | ATPase family protein 2 homolog; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression. Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit. Controls ER transition into she [...] (724 aa) |
| | ile-1 | L-type lectin-like domain-containing protein. (492 aa) |
| | mek-1 | Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] (347 aa) |
| | pdr-1 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (386 aa) |
| | cul-6 | Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa) |
| | skr-21 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (176 aa) |
| | ostd-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (280 aa) |
| | let-70 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Mediates the selective degradation of short- lived and abnormal proteins. Plays a role in the DNA damage response. In particular, in response to ionizing radiation, associates with the E3 ubiquitin-protein ligase brc-1-brd-1 heterodimer on chromatin to activate E3-ubiquitin ligase activity of the heterodimer, and thus its DNA damage repair mechanisms ; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | skr-19 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (155 aa) |
| | skr-20 | SKp1 Related (Ubiquitin ligase complex component). (173 aa) |
| | R151.6 | Derlin-2; May be required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Its precise function remains unclear, but its ability to complement der1 mutations in C.cerevisiae, suggests a similar function in the degradation of ER misfolded proteins. (237 aa) |
| | xbp-1 | BZIP domain-containing protein. (335 aa) |
| | mans-3 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (584 aa) |
| | atf-5 | BZIP domain-containing protein. (208 aa) |
| | ile-2 | L-type lectin-like domain-containing protein. (347 aa) |
| | trap-2 | Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (188 aa) |
| | dnj-19 | DNaJ domain (Prokaryotic heat shock protein). (439 aa) |
| | enpl-1 | Endoplasmin homolog; Molecular chaperone that functions in the processing and transport of secreted proteins; Belongs to the heat shock protein 90 family. (760 aa) |
| | ufd-2 | Ubiquitin conjugation factor E4 ufd-2; Acts as an E4 ubiquitin ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. The elongation of preexisting ubiquitin chains preferentially targets ubiquitin 'Lys-29' and 'Lys-48' residues. Also functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Probably by regulating protein ubiquitination at DNA damage repair sites, coordinates DNA double- strand-break repair and apoptosis in the germline. Required for germline apoptosis in response to DNA damage downstream of cep [...] (984 aa) |
| | kgb-1 | GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] (390 aa) |
| | ostb-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (445 aa) |
| | chn-1 | C-term of Hsp70-iNteracting protein (CHIP family). (266 aa) |
| | stt-3 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] (757 aa) |
| | T14G8.3 | Uncharacterized protein. (921 aa) |
| | dnj-20 | DnaJ homolog dnj-20. (355 aa) |
| | skn-1 | Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa) |
| | ribo-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (586 aa) |
| | T24H7.2 | Uncharacterized protein. (925 aa) |
| | skr-10 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa) |
| | Y105E8A.2 | Uncharacterized protein. (535 aa) |
| | ero-1 | Endoplasmic reticulum oxidoreductin-1; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). (513 aa) |
| | ubc-26 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (238 aa) |
| | ubc-15 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (551 aa) |
| | sec-23 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (821 aa) |
| | eif-2alpha | S1 motif domain-containing protein. (342 aa) |
| | skr-6 | SKp1 Related (Ubiquitin ligase complex component). (106 aa) |
| | crt-1 | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegen [...] (395 aa) |
| | trap-3 | TRanslocon-Associated Protein. (178 aa) |
| | Y38F2AR.9 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (81 aa) |
| | skr-7 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | skr-14 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa) |
| | dnj-27 | DNaJ domain (Prokaryotic heat shock protein). (788 aa) |
| | Y49E10.4 | Uncharacterized protein; Belongs to the protein disulfide isomerase family. (436 aa) |
| | dnj-28 | DNaJ domain (Prokaryotic heat shock protein). (494 aa) |
| | Y54G2A.18 | 4D656. (213 aa) |
| | Y56A3A.2 | Peptidase_M50 domain-containing protein. (616 aa) |
| | trap-4 | TRanslocon-Associated Protein. (159 aa) |
| | sec-61 | Plug_translocon domain-containing protein. (473 aa) |
| | skr-4 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa) |
| | dnj-29 | J domain-containing protein. (752 aa) |
| | trap-1 | TRanslocon-Associated Protein. (257 aa) |
| | npp-20 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa) |
| | gcn-2 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] (1699 aa) |
| | ubc-14 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | ubxn-2 | UBX domain-containing protein 2; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase. Also, regulates spindle orientation in the one-cell embryo by controlling [...] (301 aa) |
| | mans-4 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (532 aa) |
| | kgb-2 | Mitogen-activated protein kinase. (332 aa) |
| | ZC506.1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (931 aa) |
| | sec-24.2 | Yeast SEC homolog. (984 aa) |
| | ZK1307.8 | Uncharacterized protein. (507 aa) |
| | sar-1 | GTP-binding protein SAR1; Involved in transport from the endoplasmic reticulum to the Golgi apparatus; Belongs to the small GTPase superfamily. SAR1 family. (193 aa) |
| | rad-23 | Uncharacterized protein. (323 aa) |
| | rbx-1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. (110 aa) |
| | ubxn-4 | UBX domain-containing protein 4; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. May play a role in the ER- associated protein degradation pathway (ERAD) possibly acting as a platform to recruit both ubql-1 and cdc-48.1 and/or cdc-48.2 to the ER during ERAD. (469 aa) |
| | cnx-1 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death. (619 aa) |
| | ZK686.3 | Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation acro [...] (331 aa) |
