Your Input: | |
| | arf-1.2 | ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. (181 aa) |
| | C01A2.4 | Uncharacterized protein. (207 aa) |
| | dyn-1 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa) |
| | pld-1 | Phospholipase. (1427 aa) |
| | snx-1 | PX domain-containing protein. (472 aa) |
| | mvb-12 | MVB (Yeast MultiVesicular Body sorting factor) related. (277 aa) |
| | wsp-1 | WASP (Actin cytoskeleton modulator) homolog. (781 aa) |
| | hgrs-1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. (729 aa) |
| | tsg-101 | Tumor Susceptibility Gene homolog. (425 aa) |
| | hsp-70 | Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa) |
| | gbf-1 | SEC7 domain-containing protein. (1975 aa) |
| | vps-22 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (269 aa) |
| | stam-1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa) |
| | arx-6 | Probable actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (169 aa) |
| | vps-45 | Related to yeast Vacuolar Protein Sorting factor. (547 aa) |
| | C46H11.3 | Probable actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (146 aa) |
| | cav-2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. Belongs to the caveolin family. (351 aa) |
| | vps-32.1 | Related to yeast Vacuolar Protein Sorting factor. (221 aa) |
| | vps-37 | VPS37 C-terminal domain-containing protein. (234 aa) |
| | rab-8 | RAB family. (211 aa) |
| | cap-1 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa) |
| | usp-50 | USP domain-containing protein; Belongs to the peptidase C19 family. (811 aa) |
| | rabn-5 | FYVE-type domain-containing protein. (414 aa) |
| | aps-2 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa) |
| | F07F6.4 | Uncharacterized protein F07F6.4; GTPase-activating protein for the ADP ribosylation factor family. (529 aa) |
| | pkc-3 | Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. (597 aa) |
| | F11F1.1 | DUF148 domain-containing protein; Belongs to the heat shock protein 70 family. (607 aa) |
| | git-1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. (670 aa) |
| | vps-36 | GLUE N-terminal domain-containing protein. (383 aa) |
| | grk-1 | G protein-coupled receptor kinase 1; Specifically phosphorylates the activated forms of G protein- coupled receptors; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (642 aa) |
| | did-2 | Doa4-Independent Degradation, homologous to yeast Did2. (205 aa) |
| | hsp-1 | Heat shock 70 kDa protein A. (640 aa) |
| | rab-5 | RAB family. (208 aa) |
| | F35A5.8 | BAR domain-containing protein. (366 aa) |
| | vps-60 | Related to yeast Vacuolar Protein Sorting factor. (217 aa) |
| | F44E5.4 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (645 aa) |
| | arf-1.1 | ADP-ribosylation factor 1-like 1; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family. (179 aa) |
| | rab-11.1 | Ras-related protein rab-11.1; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in regulating the meiotic maturation of oocytes. Plays a role in egg shell formation, regulating exocytosis of chondroitin proteoglycans following fertilization. Controls cor [...] (211 aa) |
| | arr-1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. (435 aa) |
| | par-3 | Partitioning defective protein 3; In cooperation with pkc-3, required for establishing cell polarity and regulating spindle orientation in the early embryo. Localization is crucial for recruiting par-6 and pkc-3 to the peripheral apical cortex and restricting par-2 to basolateral surfaces. Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cycles of embryogenesis, and also for epithelial cell polarity in the distal spermatheca. Regulates the asymmetric localization of csnk-1, ppk-1 and gpr-1/2 during the first [...] (1533 aa) |
| | ppk-1 | PIPK domain-containing protein. (611 aa) |
| | rfip-1 | FIP-RBD domain-containing protein. (471 aa) |
| | spg-20 | MIT domain-containing protein. (476 aa) |
| | arf-3 | ADP-ribosylation factor related (20.5 kD) (Arf-3); Belongs to the small GTPase superfamily. Arf family. (180 aa) |
| | amph-1 | AMPHiphysin homolog. (461 aa) |
| | ddl-1 | WASH complex subunit homolog 3; Belongs to the CCDC53 family. (189 aa) |
| | vps-35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (821 aa) |
| | K02B12.7 | Arf-GAP domain-containing protein. (423 aa) |
| | grp-1 | GTP exchange factor for ARFs 1; Promotes guanine-nucleotide exchange on ARF. Promotes the activation of ARF through replacement of GDP with GTP (By similarity). Plays a role in cell shedding during embryogenesis, probably by promoting the endocytosis of cell adhesion molecules. (393 aa) |
| | istr-1 | Increased Sodium Tolerance Related. (445 aa) |
| | arx-7 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa) |
| | bris-1 | SEC7 domain-containing protein. (640 aa) |
| | cap-2 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa) |
| | dab-1 | PID domain-containing protein. (492 aa) |
| | unc-116 | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. (815 aa) |
| | cdc-42 | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa) |
| | alx-1 | Apoptosis-linked gene 2-interacting protein X 1; Required for lin-12 degradation after it has been internalised in the vulval precursor cells. (882 aa) |
| | R12C12.5 | Uncharacterized protein. (236 aa) |
| | dpy-23 | AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...] (441 aa) |
| | epn-1 | ENTH domain-containing protein. (469 aa) |
| | unc-57 | Endophilin-A homolog; Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis. By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion. In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels. Plays a minor role in responses to mechanical stimuli. Plays a minor role in unc- 26/synaptojanin localization to synapses. (381 aa) |
| | T05E7.3 | Uncharacterized protein. (997 aa) |
| | eea-1 | FYVE-type domain-containing protein. (1205 aa) |
| | cav-1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (235 aa) |
| | apa-2 | AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa) |
| | vps-26 | Vacuolar protein sorting-associated protein 26; May play a role in vesicular protein sorting, similar to the yeast retromer proteins. (410 aa) |
| | chc-1 | Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family. (1681 aa) |
| | rab-10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa) |
| | T24B8.2 | Charged Multivesicular Body Protein homolog. (411 aa) |
| | par-6 | Partitioning defective protein 6; Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis. Required for localizing/ maintaining par-3 at the cell periphery. Regulates mes-1 expression and/or localization pattern during early embryogenesis. Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca. Plays a role in endosome and Golgi body positioning. Belongs to the PAR6 family. (309 aa) |
| | vps-24 | Related to yeast Vacuolar Protein Sorting factor. (208 aa) |
| | ppk-3 | PIP Kinase. (1497 aa) |
| | vps-25 | Related to yeast Vacuolar Protein Sorting factor. (183 aa) |
| | grk-2 | G protein-coupled receptor kinase 2; Specifically phosphorylates the activated forms of G protein- coupled receptors (By similarity). Required in adult sensory neurons for chemotaxis. Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations. Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin. Acts in head acetylcholine neurons to pos [...] (707 aa) |
| | rab-7 | RAB family. (209 aa) |
| | rab-11.2 | RAB family. (198 aa) |
| | snx-3 | PX domain-containing protein. (162 aa) |
| | rme-1 | Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa) |
| | W09D10.1 | Arf-GAP domain-containing protein. (495 aa) |
| | arf-6 | ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family. (175 aa) |
| | cnt-1 | Arf-GAP with ANK repeat and PH domain-containing protein cnt-1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6. (826 aa) |
| | crp-1 | Cdc-42 Related Protein. (187 aa) |
| | vps-4 | Related to yeast Vacuolar Protein Sorting factor; Belongs to the AAA ATPase family. (430 aa) |
| | arx-5 | Probable actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa) |
| | cnt-2 | Arf-GAP with ANK repeat and PH domain-containing protein cnt-2; GTPase-activating protein for the ADP ribosylation factor family (Probable). During neurogenesis, involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell probably by controlling endocytosis. In oocytes, involved in vitellogenin vit-2 uptake by regulating receptor rme-2 endocytosis; Belongs to the centaurin gamma-like family. (1107 aa) |
| | rabs-5 | FYVE-type domain-containing protein. (565 aa) |
| | vps-2 | Related to yeast Vacuolar Protein Sorting factor. (237 aa) |
| | rab-35 | RAB family. (209 aa) |
| | ddl-2 | WASH_WAHD domain-containing protein. (497 aa) |
| | rho-1 | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa) |
| | Y53F4B.21 | Uncharacterized protein. (1145 aa) |
| | snx-6 | PX domain-containing protein. (478 aa) |
| | vps-20 | Related to yeast Vacuolar Protein Sorting factor. (208 aa) |
| | wwp-1 | E3 ubiquitin-protein ligase. (794 aa) |
| | agef-1 | SEC7 domain-containing protein. (1594 aa) |
| | arx-4 | Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (301 aa) |
| | apb-1 | AP complex subunit beta. (955 aa) |
| | arx-3 | Actin-related protein 2/3 complex subunit. (375 aa) |
| | vps-28 | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa) |
| | src-1 | Tyrosine protein-kinase src-1; Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal muscle organization in the adult. Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion. Plays a role in the migration of the QR neuroblast, a precursor of the A [...] (537 aa) |
| | Y92H12A.2 | E3 ubiquitin-protein ligase. (724 aa) |
| | let-23 | Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] (1335 aa) |
| | vps-29 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (191 aa) |
| | ehs-1 | Eps15 (Endocytosis protein) Homologous Sequence. (796 aa) |
