Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| F35B12.10 | dbl-1 | F35B12.10c.1 | T25F10.2.1 | CTCK domain-containing protein. | TGF_BETA_2 domain-containing protein. | 0.956 |
| R04A9.7 | let-92 | R04A9.7.1 | F38H4.9.2 | Uncharacterized protein; Belongs to the protein kinase superfamily. | Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...] | 0.924 |
| R04A9.7 | paa-1 | R04A9.7.1 | F48E8.5.2 | Uncharacterized protein; Belongs to the protein kinase superfamily. | Probable serine/threonine-protein phosphatase PP2A regulatory subunit; Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1. During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase sign [...] | 0.904 |
| R04A9.7 | rsks-1 | R04A9.7.1 | Y47D3A.16.1 | Uncharacterized protein; Belongs to the protein kinase superfamily. | Ribosomal protein S6 kinase beta; Serine/threonine-protein kinase which regulates mRNA translation. Negatively regulates lifespan and resistance to starvation, oxidative stress, protein aggregation and P.aeruginosa-mediated infection. May regulate these processes by preventing the activation of transcription factor hif-1. Required, probably downstream of let-363/TOR, for the establishment of the proper number of germline progenitors by promoting cell cycle progression and preventing differentiation during larval development. Regulates germ cell size. In addition required for sperm prod [...] | 0.904 |
| R04A9.7 | skr-7 | R04A9.7.1 | Y47D7A.1.1 | Uncharacterized protein; Belongs to the protein kinase superfamily. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.795 |
| R04A9.7 | skr-8 | R04A9.7.1 | C52D10.9.1 | Uncharacterized protein; Belongs to the protein kinase superfamily. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.809 |
| R04A9.7 | skr-9 | R04A9.7.1 | C52D10.7.1 | Uncharacterized protein; Belongs to the protein kinase superfamily. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.810 |
| cbp-1 | dbl-1 | R10E11.1b.1 | T25F10.2.1 | Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. | TGF_BETA_2 domain-containing protein. | 0.470 |
| cul-1 | cul-6 | D2045.6.1 | K08E7.7a.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.907 |
| cul-1 | efl-1 | D2045.6.1 | Y102A5C.18.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | E2F_TDP domain-containing protein; Belongs to the E2F/DP family. | 0.633 |
| cul-1 | let-92 | D2045.6.1 | F38H4.9.2 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...] | 0.635 |
| cul-1 | lin-35 | D2045.6.1 | C32F10.2.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | 0.749 |
| cul-1 | paa-1 | D2045.6.1 | F48E8.5.2 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | Probable serine/threonine-protein phosphatase PP2A regulatory subunit; Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1. During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase sign [...] | 0.551 |
| cul-1 | rbx-1 | D2045.6.1 | ZK287.5.2 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.999 |
| cul-1 | rho-1 | D2045.6.1 | Y51H4A.3a.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] | 0.608 |
| cul-1 | skr-1 | D2045.6.1 | F46A9.5.4 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. | 0.999 |
| cul-1 | skr-10 | D2045.6.1 | Y105C5B.13.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.997 |
| cul-1 | skr-12 | D2045.6.1 | C52D10.6.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.995 |
| cul-1 | skr-13 | D2045.6.1 | C52D10.8.1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.996 |
| cul-1 | skr-14 | D2045.6.1 | Y47D7A.8.3 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. | 0.996 |
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