STRINGSTRING
SLG_01790 SLG_01790 SLG_01800 SLG_01800 xseA xseA desB desB SLG_03910 SLG_03910 SLG_05030 SLG_05030 rph rph SLG_05140 SLG_05140 SLG_05360 SLG_05360 rnhA rnhA SLG_06020 SLG_06020 SLG_06380 SLG_06380 SLG_06470 SLG_06470 tfdA tfdA ligY ligY SLG_08260 SLG_08260 SLG_08280 SLG_08280 ligD ligD ligF ligF ligE ligE tauD tauD SLG_10600 SLG_10600 SLG_10680 SLG_10680 SLG_11100 SLG_11100 SLG_11280 SLG_11280 SLG_11330 SLG_11330 pnp pnp SLG_11890 SLG_11890 phhA phhA SLG_12180 SLG_12180 SLG_12270 SLG_12270 SLG_12310 SLG_12310 tfdA-2 tfdA-2 ligC ligC ligB ligB ligA-2 ligA-2 ligJ ligJ ligK ligK ligI ligI ligM ligM SLG_13510 SLG_13510 SLG_14270 SLG_14270 SLG_15360 SLG_15360 SLG_15590 SLG_15590 SLG_16210 SLG_16210 SLG_16220 SLG_16220 SLG_16230 SLG_16230 SLG_16650 SLG_16650 SLG_17920 SLG_17920 SLG_18240 SLG_18240 SLG_18290 SLG_18290 SLG_18930 SLG_18930 SLG_19020 SLG_19020 SLG_19060 SLG_19060 SLG_19130 SLG_19130 rnhB rnhB SLG_23490 SLG_23490 desA desA SLG_27070 SLG_27070 SLG_27080 SLG_27080 SLG_27670 SLG_27670 SLG_28100 SLG_28100 SLG_28130 SLG_28130 SLG_28580 SLG_28580 SLG_28610 SLG_28610 SLG_28630 SLG_28630 tfdA-3 tfdA-3 SLG_29050 SLG_29050 SLG_29990 SLG_29990 SLG_30070 SLG_30070 SLG_30080 SLG_30080 xseB xseB SLG_31090 SLG_31090 SLG_31120 SLG_31120 SLG_31130 SLG_31130 SLG_31190 SLG_31190 SLG_31300 SLG_31300 SLG_31840 SLG_31840 cdd cdd SLG_32580 SLG_32580 ligP ligP surE surE SLG_33500 SLG_33500 SLG_34850 SLG_34850 SLG_35000 SLG_35000 dut dut rne rne SLG_37520 SLG_37520 SLG_37530 SLG_37530 SLG_38750 SLG_38750
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLG_01790Protocatechuate 4,5-dioxygenase alpha chain. (133 aa)
SLG_01800Protocatechuate 4,5-dioxygenase beta chain. (289 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (502 aa)
desBGallate dioxygenase. (418 aa)
SLG_03910Hypothetical protein. (603 aa)
SLG_05030Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (207 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa)
SLG_05140Putative helicase. (603 aa)
SLG_05360Putative dienelactone hydrolase. (238 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (152 aa)
SLG_06020dGTPase; Belongs to the dGTPase family. Type 2 subfamily. (386 aa)
SLG_06380Fumarylacetoacetase; Protein synonym:fumarylacetoacetate hydrolase. (432 aa)
SLG_06470Putative hydrolase. (287 aa)
tfdAAlpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase. (303 aa)
ligY2,2',3-trihydroxy-3'-methoxy-5, 5'-dicarboxybiphenyl meta-cleavage compound hydrolase. (332 aa)
SLG_08260Putative oxidoreductase. (184 aa)
SLG_08280Putative nucleotidase; Belongs to the 5'-nucleotidase family. (575 aa)
ligDC alpha-dehydrogenase; Catalyzes the C alpha dehydrogenation of arylglycerol-beta- aryl ether (C alpha alcohol type) (compound IV); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (305 aa)
ligFBeta-etherase; Lignin degradation enzyme. (257 aa)
ligEBeta-etherase; Able to degrade various dimeric lignin compounds. Catalyzes the unique and reductive cleavage of arylglycerol-beta-aryl ether; Belongs to the GST superfamily. (281 aa)
tauDPutative alpha-ketoglutarate-dependent taurine dioxygenase; Protein synonym:2-aminoethanesulfonate dioxygenase; protein synonym:sulfate starvation-induced protein 3. (291 aa)
SLG_10600Putative alkylsulfatase. (317 aa)
SLG_10680Carboxymethylenebutenolidase. (231 aa)
SLG_11100Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (338 aa)
SLG_11280Conserved hypothetical protein. (296 aa)
SLG_11330Aromatic ring hydroxylase. (482 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (780 aa)
SLG_11890Putative hydrolase. (283 aa)
phhAPhenylalanine 4-monooxygenase. (290 aa)
SLG_12180HpcH/HpaI aldolase/citrate lyase family protein; Belongs to the HpcH/HpaI aldolase family. (259 aa)
SLG_12270Hypothetical protein. (338 aa)
SLG_12310Conserved hypothetical membrane protein. (128 aa)
tfdA-2Alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase. (307 aa)
ligC4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase; Involved in the degradation of protocatechuate (PCA) via the PCA 4,5-cleavage pathway. Catalyzes the oxidation of the hemiacetal form of 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) to produce 2- pyrone-4,6-dicarboxylate (PDC). LigC has 10-times-higher affinity to NADP than to NAD. (315 aa)
ligBProtocatechuate 4,5-dioxygenase beta chain; Responsible for the aromatic ring fission of protocatechuate. (302 aa)
ligA-2Protocatechuate 4,5-dioxygenase alpha chain; Responsible for the aromatic ring fission of protocatechuate. (139 aa)
ligJ4-oxalomesaconate hydratase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydration of the double bond of (3Z)-2-keto-4-carboxy-3-hexenedioate (KCH) to (4S)-4- carboxy-4-hydroxy-2-oxoadipate (CHA, also named (2S)-2-hydroxy-4- oxobutane-1,2,4-tricarboxylate). Is involved in the catabolism of both vanillate and syringate. (341 aa)
ligK4-hydroxy-4-methyl-2-oxoadipate aldolase; Contributes to the degradation of lignin, being involved in the final step of the protocatechuate 4,5-cleavage pathway. Catalyzes the conversion of 4-carboxy-4-hydroxy-2-oxoadipate (CHA, also named 2- hydroxy-4-oxobutane-1,2,4-tricarboxylate) to pyruvate and oxaloacetate but also the decarboxylation of oxaloacetate to pyruvate and CO2. Is essential for catabolism and utilization of vanillate and syringate. Is also able to catalyze the formation of 4-hydroxy- 4-methyl-2-oxoglutarate (HMG) from two molecules of pyruvate ; Belongs to the LigK/PcmE [...] (228 aa)
ligI2-pyrone-4,6-dicarboxylic acid hydrolase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions. Also catalyzes the reverse reaction. Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate. Belongs to the metallo-dependent hydrolases superfamily. PDC hydrola [...] (293 aa)
ligMvanillate/3-O-methylgallate O-demethylase; Involved in the catabolism of vanillate and syringate. Catalyzes the transfer of a methyl moiety from vanillate or 3-O- methylgallate (3MGA) to tetrahydrofolate, forming protocatechuate (PCA) or gallate, respectively, and methyl-tetrahydrofolate. Has similar activities with both substrates. Cannot use syringate. Uses an ordered, sequential kinetic mechanism. (471 aa)
SLG_13510Conserved hypothetical protein. (502 aa)
SLG_14270Conserved hypothetical protein. (343 aa)
SLG_15360Putative hydrolase. (308 aa)
SLG_15590Putative nucleosidase. (168 aa)
SLG_16210Xanthine dehydrogenase accessory factor. (305 aa)
SLG_16220Oxidoreductase. (156 aa)
SLG_16230Putative oxidoreductase. (735 aa)
SLG_16650Aromatic-ring-hydroxylating dioxygenase beta subunit. (170 aa)
SLG_17920Nucleoside triphosphate pyrophosphohydrolase. (258 aa)
SLG_18240Putative hydrolase. (555 aa)
SLG_18290Putative hydrolase. (562 aa)
SLG_18930Putative hydrolase. (279 aa)
SLG_19020Aminocarboxymuconate-semialdehyde decarboxylase. (349 aa)
SLG_19060Putative aldolase. (221 aa)
SLG_19130Putative hydrolase. (264 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (193 aa)
SLG_23490Conserved hypothetical protein. (120 aa)
desASyringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. (462 aa)
SLG_27070Putative oxidoreductase. (316 aa)
SLG_27080Xanthine dehydrogenase. (211 aa)
SLG_27670Putative R-2,4-dichlorophenoxypropionate dioxygenase. (317 aa)
SLG_28100Putative metal-dependent hydrolase. (292 aa)
SLG_28130Conserved hypothetical protein. (268 aa)
SLG_28580Putative fumarylacetoacetase. (429 aa)
SLG_28610Conserved hypothetical protein. (311 aa)
SLG_28630Glyoxalase-family protein. (302 aa)
tfdA-3Alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase. (291 aa)
SLG_29050Putative helicase; Belongs to the DEAD box helicase family. (472 aa)
SLG_29990Putative helicase; Belongs to the DEAD box helicase family. (588 aa)
SLG_30070[2Fe-2S]-binding protein. (169 aa)
SLG_30080Putative oxidoreductase. (328 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (81 aa)
SLG_31090Conserved hypothetical protein. (572 aa)
SLG_31120Putative hydrolase. (571 aa)
SLG_31130Conserved hypothetical protein. (566 aa)
SLG_31190Conserved hypothetical protein. (286 aa)
SLG_31300Putative hydrolase. (283 aa)
SLG_31840Putative hydrolase; Belongs to the Nudix hydrolase family. (301 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (152 aa)
SLG_32580Putative hydrolase. (555 aa)
ligPBeta-etherase. (281 aa)
surE5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (254 aa)
SLG_33500Conserved hypothetical protein. (225 aa)
SLG_34850Putative hydrolase. (269 aa)
SLG_35000Putative hydrolase. (351 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (156 aa)
rnePutative ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (919 aa)
SLG_37520Protocatechuate 4,5-dioxygenase beta chain. (286 aa)
SLG_37530Protocatechuate 4,5-dioxygenase alpha chain. (124 aa)
SLG_38750Isoquinoline 1-oxidoreductase beta subunit. (759 aa)
Your Current Organism:
Sphingobium sp. SYK6
NCBI taxonomy Id: 627192
Other names: S. sp. SYK-6, Sphingobium sp. SYK-6
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.