STRINGSTRING
ligV ligV desB desB gst gst ligZ ligZ ligD ligD ligF ligF ligE ligE ligG ligG ligC ligC ligJ ligJ ligK ligK ligI ligI ligM ligM pcaC pcaC pobA pobA phaG phaG desZ desZ pcaC-2 pcaC-2 desA desA ferA ferA pcaF pcaF gst-2 gst-2 gst-3 gst-3 gst-4 gst-4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
ligVVanillin dehydrogenase; Belongs to the aldehyde dehydrogenase family. (480 aa)
desBGallate dioxygenase. (418 aa)
gstGlutathione S-transferase; Belongs to the GST superfamily. (299 aa)
ligZ2,2',3-trihydroxy-3'-methoxy-5, 5'-dicarboxybiphenyl dioxygenase. (336 aa)
ligDC alpha-dehydrogenase; Catalyzes the C alpha dehydrogenation of arylglycerol-beta- aryl ether (C alpha alcohol type) (compound IV); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (305 aa)
ligFBeta-etherase; Lignin degradation enzyme. (257 aa)
ligEBeta-etherase; Able to degrade various dimeric lignin compounds. Catalyzes the unique and reductive cleavage of arylglycerol-beta-aryl ether; Belongs to the GST superfamily. (281 aa)
ligGGlutathione S-transferase. (265 aa)
ligC4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase; Involved in the degradation of protocatechuate (PCA) via the PCA 4,5-cleavage pathway. Catalyzes the oxidation of the hemiacetal form of 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) to produce 2- pyrone-4,6-dicarboxylate (PDC). LigC has 10-times-higher affinity to NADP than to NAD. (315 aa)
ligJ4-oxalomesaconate hydratase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydration of the double bond of (3Z)-2-keto-4-carboxy-3-hexenedioate (KCH) to (4S)-4- carboxy-4-hydroxy-2-oxoadipate (CHA, also named (2S)-2-hydroxy-4- oxobutane-1,2,4-tricarboxylate). Is involved in the catabolism of both vanillate and syringate. (341 aa)
ligK4-hydroxy-4-methyl-2-oxoadipate aldolase; Contributes to the degradation of lignin, being involved in the final step of the protocatechuate 4,5-cleavage pathway. Catalyzes the conversion of 4-carboxy-4-hydroxy-2-oxoadipate (CHA, also named 2- hydroxy-4-oxobutane-1,2,4-tricarboxylate) to pyruvate and oxaloacetate but also the decarboxylation of oxaloacetate to pyruvate and CO2. Is essential for catabolism and utilization of vanillate and syringate. Is also able to catalyze the formation of 4-hydroxy- 4-methyl-2-oxoglutarate (HMG) from two molecules of pyruvate ; Belongs to the LigK/PcmE [...] (228 aa)
ligI2-pyrone-4,6-dicarboxylic acid hydrolase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions. Also catalyzes the reverse reaction. Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate. Belongs to the metallo-dependent hydrolases superfamily. PDC hydrola [...] (293 aa)
ligMvanillate/3-O-methylgallate O-demethylase; Involved in the catabolism of vanillate and syringate. Catalyzes the transfer of a methyl moiety from vanillate or 3-O- methylgallate (3MGA) to tetrahydrofolate, forming protocatechuate (PCA) or gallate, respectively, and methyl-tetrahydrofolate. Has similar activities with both substrates. Cannot use syringate. Uses an ordered, sequential kinetic mechanism. (471 aa)
pcaC4-carboxymuconolactone decarboxylase. (124 aa)
pobAP-hydroxybenzoate 3-monooxygenase. (391 aa)
phaGPutative K(+)/H(+) antiporter subunit G. (135 aa)
desZ3-O-methylgallate 3,4-dioxygenase. (330 aa)
pcaC-24-carboxymuconolactone decarboxylase. (150 aa)
desASyringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. (462 aa)
ferAferuloyl-CoA synthetase. (709 aa)
pcaFProtein synonym:3-ketoacyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
gst-2Glutathione S-transferase. (229 aa)
gst-3Glutathione S-transferase. (223 aa)
gst-4Glutathione S-transferase; Belongs to the GST superfamily. (206 aa)
Your Current Organism:
Sphingobium sp. SYK6
NCBI taxonomy Id: 627192
Other names: S. sp. SYK-6, Sphingobium sp. SYK-6
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