node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
desA | desZ | SLG_25000 | SLG_19030 | Syringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. | 3-O-methylgallate 3,4-dioxygenase. | 0.932 |
desA | ferA | SLG_25000 | SLG_25020 | Syringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. | feruloyl-CoA synthetase. | 0.667 |
desA | ligI | SLG_25000 | SLG_12570 | Syringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. | 2-pyrone-4,6-dicarboxylic acid hydrolase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions. Also catalyzes the reverse reaction. Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate. Belongs to the metallo-dependent hydrolases superfamily. PDC hydrola [...] | 0.426 |
desA | ligJ | SLG_25000 | SLG_12520 | Syringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. | 4-oxalomesaconate hydratase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydration of the double bond of (3Z)-2-keto-4-carboxy-3-hexenedioate (KCH) to (4S)-4- carboxy-4-hydroxy-2-oxoadipate (CHA, also named (2S)-2-hydroxy-4- oxobutane-1,2,4-tricarboxylate). Is involved in the catabolism of both vanillate and syringate. | 0.504 |
desA | ligK | SLG_25000 | SLG_12550 | Syringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. | 4-hydroxy-4-methyl-2-oxoadipate aldolase; Contributes to the degradation of lignin, being involved in the final step of the protocatechuate 4,5-cleavage pathway. Catalyzes the conversion of 4-carboxy-4-hydroxy-2-oxoadipate (CHA, also named 2- hydroxy-4-oxobutane-1,2,4-tricarboxylate) to pyruvate and oxaloacetate but also the decarboxylation of oxaloacetate to pyruvate and CO2. Is essential for catabolism and utilization of vanillate and syringate. Is also able to catalyze the formation of 4-hydroxy- 4-methyl-2-oxoglutarate (HMG) from two molecules of pyruvate ; Belongs to the LigK/PcmE [...] | 0.560 |
desA | ligM | SLG_25000 | SLG_12740 | Syringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. | vanillate/3-O-methylgallate O-demethylase; Involved in the catabolism of vanillate and syringate. Catalyzes the transfer of a methyl moiety from vanillate or 3-O- methylgallate (3MGA) to tetrahydrofolate, forming protocatechuate (PCA) or gallate, respectively, and methyl-tetrahydrofolate. Has similar activities with both substrates. Cannot use syringate. Uses an ordered, sequential kinetic mechanism. | 0.909 |
desA | pobA | SLG_25000 | SLG_16860 | Syringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. | P-hydroxybenzoate 3-monooxygenase. | 0.516 |
desB | desZ | SLG_03330 | SLG_19030 | Gallate dioxygenase. | 3-O-methylgallate 3,4-dioxygenase. | 0.488 |
desB | ligC | SLG_03330 | SLG_12490 | Gallate dioxygenase. | 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase; Involved in the degradation of protocatechuate (PCA) via the PCA 4,5-cleavage pathway. Catalyzes the oxidation of the hemiacetal form of 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) to produce 2- pyrone-4,6-dicarboxylate (PDC). LigC has 10-times-higher affinity to NADP than to NAD. | 0.870 |
desB | ligI | SLG_03330 | SLG_12570 | Gallate dioxygenase. | 2-pyrone-4,6-dicarboxylic acid hydrolase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions. Also catalyzes the reverse reaction. Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate. Belongs to the metallo-dependent hydrolases superfamily. PDC hydrola [...] | 0.983 |
desB | ligJ | SLG_03330 | SLG_12520 | Gallate dioxygenase. | 4-oxalomesaconate hydratase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydration of the double bond of (3Z)-2-keto-4-carboxy-3-hexenedioate (KCH) to (4S)-4- carboxy-4-hydroxy-2-oxoadipate (CHA, also named (2S)-2-hydroxy-4- oxobutane-1,2,4-tricarboxylate). Is involved in the catabolism of both vanillate and syringate. | 0.843 |
desB | ligK | SLG_03330 | SLG_12550 | Gallate dioxygenase. | 4-hydroxy-4-methyl-2-oxoadipate aldolase; Contributes to the degradation of lignin, being involved in the final step of the protocatechuate 4,5-cleavage pathway. Catalyzes the conversion of 4-carboxy-4-hydroxy-2-oxoadipate (CHA, also named 2- hydroxy-4-oxobutane-1,2,4-tricarboxylate) to pyruvate and oxaloacetate but also the decarboxylation of oxaloacetate to pyruvate and CO2. Is essential for catabolism and utilization of vanillate and syringate. Is also able to catalyze the formation of 4-hydroxy- 4-methyl-2-oxoglutarate (HMG) from two molecules of pyruvate ; Belongs to the LigK/PcmE [...] | 0.751 |
desB | ligM | SLG_03330 | SLG_12740 | Gallate dioxygenase. | vanillate/3-O-methylgallate O-demethylase; Involved in the catabolism of vanillate and syringate. Catalyzes the transfer of a methyl moiety from vanillate or 3-O- methylgallate (3MGA) to tetrahydrofolate, forming protocatechuate (PCA) or gallate, respectively, and methyl-tetrahydrofolate. Has similar activities with both substrates. Cannot use syringate. Uses an ordered, sequential kinetic mechanism. | 0.940 |
desB | pobA | SLG_03330 | SLG_16860 | Gallate dioxygenase. | P-hydroxybenzoate 3-monooxygenase. | 0.454 |
desZ | desA | SLG_19030 | SLG_25000 | 3-O-methylgallate 3,4-dioxygenase. | Syringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. | 0.932 |
desZ | desB | SLG_19030 | SLG_03330 | 3-O-methylgallate 3,4-dioxygenase. | Gallate dioxygenase. | 0.488 |
desZ | ligC | SLG_19030 | SLG_12490 | 3-O-methylgallate 3,4-dioxygenase. | 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase; Involved in the degradation of protocatechuate (PCA) via the PCA 4,5-cleavage pathway. Catalyzes the oxidation of the hemiacetal form of 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) to produce 2- pyrone-4,6-dicarboxylate (PDC). LigC has 10-times-higher affinity to NADP than to NAD. | 0.975 |
desZ | ligI | SLG_19030 | SLG_12570 | 3-O-methylgallate 3,4-dioxygenase. | 2-pyrone-4,6-dicarboxylic acid hydrolase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions. Also catalyzes the reverse reaction. Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate. Belongs to the metallo-dependent hydrolases superfamily. PDC hydrola [...] | 0.968 |
desZ | ligJ | SLG_19030 | SLG_12520 | 3-O-methylgallate 3,4-dioxygenase. | 4-oxalomesaconate hydratase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydration of the double bond of (3Z)-2-keto-4-carboxy-3-hexenedioate (KCH) to (4S)-4- carboxy-4-hydroxy-2-oxoadipate (CHA, also named (2S)-2-hydroxy-4- oxobutane-1,2,4-tricarboxylate). Is involved in the catabolism of both vanillate and syringate. | 0.807 |
desZ | ligK | SLG_19030 | SLG_12550 | 3-O-methylgallate 3,4-dioxygenase. | 4-hydroxy-4-methyl-2-oxoadipate aldolase; Contributes to the degradation of lignin, being involved in the final step of the protocatechuate 4,5-cleavage pathway. Catalyzes the conversion of 4-carboxy-4-hydroxy-2-oxoadipate (CHA, also named 2- hydroxy-4-oxobutane-1,2,4-tricarboxylate) to pyruvate and oxaloacetate but also the decarboxylation of oxaloacetate to pyruvate and CO2. Is essential for catabolism and utilization of vanillate and syringate. Is also able to catalyze the formation of 4-hydroxy- 4-methyl-2-oxoglutarate (HMG) from two molecules of pyruvate ; Belongs to the LigK/PcmE [...] | 0.618 |