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SLG_01790 SLG_01790 SLG_01800 SLG_01800 paaH paaH SLG_07730 SLG_07730 SLG_07740 SLG_07740 SLG_11600 SLG_11600 SLG_12450 SLG_12450 ligC ligC ligB ligB ligA-2 ligA-2 ligJ ligJ ligK ligK SLG_12560 SLG_12560 ligI ligI pcaC pcaC SLG_15980 SLG_15980 SLG_16640 SLG_16640 SLG_16650 SLG_16650 pobA pobA SLG_19050 SLG_19050 SLG_19060 SLG_19060 pcaC-2 pcaC-2 SLG_20150 SLG_20150 SLG_21370 SLG_21370 fadJ fadJ SLG_24630 SLG_24630 SLG_24730 SLG_24730 SLG_27270 SLG_27270 pcaF pcaF SLG_31270 SLG_31270 SLG_31300 SLG_31300 SLG_31320 SLG_31320 SLG_31440 SLG_31440 SLG_37520 SLG_37520 SLG_37530 SLG_37530
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLG_01790Protocatechuate 4,5-dioxygenase alpha chain. (133 aa)
SLG_01800Protocatechuate 4,5-dioxygenase beta chain. (289 aa)
paaH3-hydroxybutyryl-CoA dehydrogenase. (289 aa)
SLG_07730Hypothetical protein. (223 aa)
SLG_07740Putative aldolase. (222 aa)
SLG_11600Putative tautomerase; Belongs to the 4-oxalocrotonate tautomerase family. (76 aa)
SLG_12450Conserved hypothetical protein. (149 aa)
ligC4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase; Involved in the degradation of protocatechuate (PCA) via the PCA 4,5-cleavage pathway. Catalyzes the oxidation of the hemiacetal form of 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) to produce 2- pyrone-4,6-dicarboxylate (PDC). LigC has 10-times-higher affinity to NADP than to NAD. (315 aa)
ligBProtocatechuate 4,5-dioxygenase beta chain; Responsible for the aromatic ring fission of protocatechuate. (302 aa)
ligA-2Protocatechuate 4,5-dioxygenase alpha chain; Responsible for the aromatic ring fission of protocatechuate. (139 aa)
ligJ4-oxalomesaconate hydratase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydration of the double bond of (3Z)-2-keto-4-carboxy-3-hexenedioate (KCH) to (4S)-4- carboxy-4-hydroxy-2-oxoadipate (CHA, also named (2S)-2-hydroxy-4- oxobutane-1,2,4-tricarboxylate). Is involved in the catabolism of both vanillate and syringate. (341 aa)
ligK4-hydroxy-4-methyl-2-oxoadipate aldolase; Contributes to the degradation of lignin, being involved in the final step of the protocatechuate 4,5-cleavage pathway. Catalyzes the conversion of 4-carboxy-4-hydroxy-2-oxoadipate (CHA, also named 2- hydroxy-4-oxobutane-1,2,4-tricarboxylate) to pyruvate and oxaloacetate but also the decarboxylation of oxaloacetate to pyruvate and CO2. Is essential for catabolism and utilization of vanillate and syringate. Is also able to catalyze the formation of 4-hydroxy- 4-methyl-2-oxoglutarate (HMG) from two molecules of pyruvate ; Belongs to the LigK/PcmE [...] (228 aa)
SLG_12560Hypothetical protein. (351 aa)
ligI2-pyrone-4,6-dicarboxylic acid hydrolase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions. Also catalyzes the reverse reaction. Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate. Belongs to the metallo-dependent hydrolases superfamily. PDC hydrola [...] (293 aa)
pcaC4-carboxymuconolactone decarboxylase. (124 aa)
SLG_15980enoyl-CoA hydratase; Protein synonym:unsaturated acyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
SLG_16640Aromatic-ring-hydroxylating dioxygenase alpha subunit. (450 aa)
SLG_16650Aromatic-ring-hydroxylating dioxygenase beta subunit. (170 aa)
pobAP-hydroxybenzoate 3-monooxygenase. (391 aa)
SLG_19050Putative aldolase. (217 aa)
SLG_19060Putative aldolase. (221 aa)
pcaC-24-carboxymuconolactone decarboxylase. (150 aa)
SLG_20150Putative cytochrome P450. (393 aa)
SLG_21370acetyl-CoA acyltransferase; Protein synonym:3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
fadJFatty oxidation complex alpha subunit; Protein synonym:3-hydroxyacyl-CoA dehydrogenase. (731 aa)
SLG_24630Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
SLG_24730Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
SLG_27270Beta-ketoadipate enol-lactone hydrolase. (267 aa)
pcaFProtein synonym:3-ketoacyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
SLG_31270Beta-ketoadipate enol-lactone hydrolase. (258 aa)
SLG_31300Putative hydrolase. (283 aa)
SLG_31320Conserved hypothetical protein. (171 aa)
SLG_31440Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
SLG_37520Protocatechuate 4,5-dioxygenase beta chain. (286 aa)
SLG_37530Protocatechuate 4,5-dioxygenase alpha chain. (124 aa)
Your Current Organism:
Sphingobium sp. SYK6
NCBI taxonomy Id: 627192
Other names: S. sp. SYK-6, Sphingobium sp. SYK-6
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