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SLG_01790 SLG_01790 SLG_01800 SLG_01800 desB desB SLG_06630 SLG_06630 ligV ligV ligZ ligZ ligY ligY ligX ligX ligW ligW ligXc ligXc ligC ligC ligB ligB ligA-2 ligA-2 ligI ligI ligM ligM ligW2 ligW2 SLG_15980 SLG_15980 acyP acyP SLG_19020 SLG_19020 desZ desZ SLG_20880 SLG_20880 ligXd ligXd mdlC mdlC desA desA SLG_31300 SLG_31300 SLG_37520 SLG_37520 SLG_37530 SLG_37530
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SLG_01790Protocatechuate 4,5-dioxygenase alpha chain. (133 aa)
SLG_01800Protocatechuate 4,5-dioxygenase beta chain. (289 aa)
desBGallate dioxygenase. (418 aa)
SLG_06630Putative hydrolase. (346 aa)
ligVVanillin dehydrogenase; Belongs to the aldehyde dehydrogenase family. (480 aa)
ligZ2,2',3-trihydroxy-3'-methoxy-5, 5'-dicarboxybiphenyl dioxygenase. (336 aa)
ligY2,2',3-trihydroxy-3'-methoxy-5, 5'-dicarboxybiphenyl meta-cleavage compound hydrolase. (332 aa)
ligX2,2'-dihydroxy-3,3'-dimethoxy-5, 5'-dicarboxybiphenyl O-demethylase oxygenase subunit; Involved in the catabolism of 5,5'-dehydrodivanillate (DDVA), an intermediate in the biodegradation of lignin. Part of a three- component monooxygenase that catalyzes the O-demethylation of DDVA, leading to the formation of 2,2',3-trihydroxy-3'-methoxy-5,5'- dicarboxybiphenyl (OH-DDVA). (424 aa)
ligW5-carboxyvanillate decarboxylase. (334 aa)
ligXcFerredoxin; Involved in the catabolism of 5,5'-dehydrodivanillate (DDVA), an intermediate in the biodegradation of lignin. Part of a three- component monooxygenase that catalyzes the O-demethylation of DDVA, leading to the formation of 2,2',3-trihydroxy-3'-methoxy-5,5'- dicarboxybiphenyl (OH-DDVA). LigXc probably functions as an intermediate electron transfer protein between LigXd and LigXa. Belongs to the adrenodoxin/putidaredoxin family. (105 aa)
ligC4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase; Involved in the degradation of protocatechuate (PCA) via the PCA 4,5-cleavage pathway. Catalyzes the oxidation of the hemiacetal form of 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) to produce 2- pyrone-4,6-dicarboxylate (PDC). LigC has 10-times-higher affinity to NADP than to NAD. (315 aa)
ligBProtocatechuate 4,5-dioxygenase beta chain; Responsible for the aromatic ring fission of protocatechuate. (302 aa)
ligA-2Protocatechuate 4,5-dioxygenase alpha chain; Responsible for the aromatic ring fission of protocatechuate. (139 aa)
ligI2-pyrone-4,6-dicarboxylic acid hydrolase; Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway. Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions. Also catalyzes the reverse reaction. Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate. Belongs to the metallo-dependent hydrolases superfamily. PDC hydrola [...] (293 aa)
ligMvanillate/3-O-methylgallate O-demethylase; Involved in the catabolism of vanillate and syringate. Catalyzes the transfer of a methyl moiety from vanillate or 3-O- methylgallate (3MGA) to tetrahydrofolate, forming protocatechuate (PCA) or gallate, respectively, and methyl-tetrahydrofolate. Has similar activities with both substrates. Cannot use syringate. Uses an ordered, sequential kinetic mechanism. (471 aa)
ligW25-carboxyvanillate decarboxylase. (350 aa)
SLG_15980enoyl-CoA hydratase; Protein synonym:unsaturated acyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
acyPAcylphosphatase. (93 aa)
SLG_19020Aminocarboxymuconate-semialdehyde decarboxylase. (349 aa)
desZ3-O-methylgallate 3,4-dioxygenase. (330 aa)
SLG_20880Putative hydrolase. (431 aa)
ligXdFAD-dependent oxidoreductase; Involved in the catabolism of 5,5'-dehydrodivanillate (DDVA), an intermediate in the biodegradation of lignin. Part of a three- component monooxygenase that catalyzes the O-demethylation of DDVA, leading to the formation of 2,2',3-trihydroxy-3'-methoxy-5,5'- dicarboxybiphenyl (OH-DDVA). LigXd probably transfers the electrons from NADH to LigXc; Belongs to the FAD-dependent oxidoreductase family. (412 aa)
mdlCBenzoylformate decarboxylase; Belongs to the TPP enzyme family. (538 aa)
desASyringate O-demethylase; Involved in the catabolism of syringate. Catalyzes the conversion of syringate to 3-O-methylgallate (3MGA) in the presence of tetrahydrofolate. Has weak activity with vanillate and 3-O- methylgallate; Belongs to the GcvT family. (462 aa)
SLG_31300Putative hydrolase. (283 aa)
SLG_37520Protocatechuate 4,5-dioxygenase beta chain. (286 aa)
SLG_37530Protocatechuate 4,5-dioxygenase alpha chain. (124 aa)
Your Current Organism:
Sphingobium sp. SYK6
NCBI taxonomy Id: 627192
Other names: S. sp. SYK-6, Sphingobium sp. SYK-6
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