(24 nodes) Activation of ATR in response to replication stress, and Unwinding of DNA network (Brugia malayi)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	bma-evl-18	BMA-EVL-18. (639 aa)
	bma-mcm-5	DNA helicase; Belongs to the MCM family. (738 aa)
	Bm1_46295	Bm10703. (307 aa)
	bma-orc-5	BMA-ORC-5. (406 aa)
	bma-mcm-7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (733 aa)
	bma-clsp-1	Bm3591, isoform b. (770 aa)
	bma-orc-1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (687 aa)
	Bma-cdc-7	BMA-CDC-7; Belongs to the protein kinase superfamily. (404 aa)
	bma-orc-4	BMA-ORC-4. (378 aa)
	Bm3422	Bm3422. (1006 aa)
	bma-tipn-1	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
	bma-psf-2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (191 aa)
	bma-mcm-6	DNA helicase; Belongs to the MCM family. (822 aa)
	bma-psf-3	BMA-PSF-3, isoform a; BMA-PSF-3, isoform b. (189 aa)
	Bm8682	Bm8682. (449 aa)
	Bm1_09210	BMA-PSF-1, isoform c. (205 aa)
	bma-cdc-6	BMA-CDC-6. (389 aa)
	A0A5S6PEL6	Uncharacterized protein. (324 aa)
	Bm1_34750	BMA-POLE-2, isoform a; BMA-POLE-2, isoform b. (274 aa)
	A0A5S6PN29	Uncharacterized protein. (448 aa)
	A0A5S6PNA8	Uncharacterized protein. (405 aa)
	Bm1_48490	DNA helicase. (813 aa)
	Bm1_20555	DNA replication complex GINS protein SLD5. (248 aa)
	BMBAC01P19.06	Probable DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. (190 aa)

Your Current Organism:

Brugia malayi

NCBI taxonomy Id: 6279
Other names: B. malayi, agent of lymphatic filariasis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5S6PEL6	A0A5S6PN29	A0A5S6PEL6	A0A5S6PN29	Uncharacterized protein.	Uncharacterized protein.	0.470
A0A5S6PEL6	A0A5S6PNA8	A0A5S6PEL6	A0A5S6PNA8	Uncharacterized protein.	Uncharacterized protein.	0.470
A0A5S6PEL6	BMBAC01P19.06	A0A5S6PEL6	Q8IHI1	Uncharacterized protein.	Probable DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication.	0.416
A0A5S6PEL6	Bm1_20555	A0A5S6PEL6	A0A5S6PUC4	Uncharacterized protein.	DNA replication complex GINS protein SLD5.	0.496
A0A5S6PEL6	Bm1_46295	A0A5S6PEL6	A0A0H5S9X9	Uncharacterized protein.	Bm10703.	0.768
A0A5S6PEL6	Bm1_48490	A0A5S6PEL6	A0A5S6PT53	Uncharacterized protein.	DNA helicase.	0.966
A0A5S6PEL6	Bm3422	A0A5S6PEL6	A0A0K0JA77	Uncharacterized protein.	Bm3422.	0.467
A0A5S6PEL6	Bm8682	A0A5S6PEL6	A0A0K0JWN9	Uncharacterized protein.	Bm8682.	0.904
A0A5S6PEL6	Bma-cdc-7	A0A5S6PEL6	A0A0J9Y6N2	Uncharacterized protein.	BMA-CDC-7; Belongs to the protein kinase superfamily.	0.802
A0A5S6PEL6	bma-cdc-6	A0A5S6PEL6	A0A1U7F1C4	Uncharacterized protein.	BMA-CDC-6.	0.905
A0A5S6PEL6	bma-clsp-1	A0A5S6PEL6	A0A0J9XRG2	Uncharacterized protein.	Bm3591, isoform b.	0.988
A0A5S6PEL6	bma-evl-18	A0A5S6PEL6	A0A0H5S3G4	Uncharacterized protein.	BMA-EVL-18.	0.904
A0A5S6PEL6	bma-mcm-5	A0A5S6PEL6	A0A0H5S7R6	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.836
A0A5S6PEL6	bma-mcm-6	A0A5S6PEL6	A0A0K0JSP7	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.863
A0A5S6PEL6	bma-mcm-7	A0A5S6PEL6	A0A0J9XQV4	Uncharacterized protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.847
A0A5S6PEL6	bma-orc-1	A0A5S6PEL6	A0A0J9XT83	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.817
A0A5S6PEL6	bma-orc-4	A0A5S6PEL6	A0A0J9Y9F2	Uncharacterized protein.	BMA-ORC-4.	0.662
A0A5S6PEL6	bma-orc-5	A0A5S6PEL6	A0A0I9R2W9	Uncharacterized protein.	BMA-ORC-5.	0.764
A0A5S6PEL6	bma-psf-2	A0A5S6PEL6	A0A0K0JBJ0	Uncharacterized protein.	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.416
A0A5S6PEL6	bma-psf-3	A0A5S6PEL6	A0A0K0JUI5	Uncharacterized protein.	BMA-PSF-3, isoform a; BMA-PSF-3, isoform b.	0.430