(40 nodes) Mixed, incl. Transmembrane receptor protein tyrosine kinase signaling pathway, and Interleukin-3, Interleukin-5 and GM-CSF signaling network (Brugia malayi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	bma-vav-1	BMA-VAV-1. (931 aa)
	bma-shc-1	BMA-SHC-1. (315 aa)
	Bma-ptp-2	BMA-PTP-2. (635 aa)
	Bm1_46080	Bm10800. (281 aa)
	Bm1_39195	Bm11003. (221 aa)
	Bma-egl-17	BMA-EGL-17; Belongs to the heparin-binding growth factors family. (215 aa)
	bma-let-23	Receptor protein-tyrosine kinase. (1277 aa)
	Bm14739	Bm14739. (181 aa)
	Bm6668	Bm6668. (629 aa)
	bma-mlk-1	BMA-MLK-1, isoform a. (1178 aa)
	bma-rol-3	Bm2256, isoform f. (1766 aa)
	Bm1_07170	Bm8702. (295 aa)
	Bm1_06995	Bm10783. (433 aa)
	bma-pxl-1	BMA-PXL-1, isoform d; BMA-PXL-1, isoform q. (402 aa)
	bma-ist-1	BMA-IST-1. (970 aa)
	bma-src-2	Tyrosine-protein kinase. (507 aa)
	bma-scd-2	Tyrosine-protein kinase receptor. (1428 aa)
	Bm1_36280	BMA-CAV-1. (255 aa)
	bma-svh-2	BMA-SVH-2, isoform a; BMA-SVH-2, isoform c; Belongs to the protein kinase superfamily. Tyr protein kinase family. (911 aa)
	Bm6361	Bm6361. (1004 aa)
	bma-ced-2	BMA-CED-2, isoform a; BMA-CED-2, isoform b. (288 aa)
	bma-cdap-2	Bm6556. (434 aa)
	Bm1_36040	Tyrosine-protein kinase. (522 aa)
	Bm10233	Bm10233, isoform a; Bm11159. (430 aa)
	Bm2341	Bm2341, isoform c. (942 aa)
	Bma-egl-15	BMA-EGL-15, isoform c; BMA-EGL-15, isoform e; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1417 aa)
	Bm5314	Bm5314, isoform m. (152 aa)
	Bma-plc-3	Phosphoinositide phospholipase C. (1075 aa)
	Bma-sta-1	Signal transducer and activator of transcription. (701 aa)
	Bm1_22505	Uncharacterized protein. (1504 aa)
	A0A5S6PGW0	Bm2256, isoform f. (1992 aa)
	A0A5S6PGX1	Bm2256, isoform f. (2239 aa)
	Bm1_40365	BMA-SSR-2. (200 aa)
	A0A5S6PHK9	BMA-KIN-32, isoform i. (843 aa)
	Bm1_43090	BMA-PTP-2. (634 aa)
	A0A5S6PPN7	Bm5314, isoform m. (1291 aa)
	A0A5S6PST2	Bm6361. (946 aa)
	A0A5S6PW68	Uncharacterized protein. (1081 aa)
	Bm1_31385	Bm8554. (351 aa)
	A0A5S6PWA6	Uncharacterized protein. (936 aa)

Your Current Organism:

Brugia malayi

NCBI taxonomy Id: 6279
Other names: B. malayi, agent of lymphatic filariasis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5S6PGW0	A0A5S6PST2	A0A5S6PGW0	A0A5S6PST2	Bm2256, isoform f.	Bm6361.	0.409
A0A5S6PGW0	Bm1_36040	A0A5S6PGW0	A0A0K0JR93	Bm2256, isoform f.	Tyrosine-protein kinase.	0.400
A0A5S6PGW0	Bm1_43090	A0A5S6PGW0	A0A5S6PNC0	Bm2256, isoform f.	BMA-PTP-2.	0.409
A0A5S6PGW0	Bm6361	A0A5S6PGW0	A0A0K0JMU8	Bm2256, isoform f.	Bm6361.	0.409
A0A5S6PGW0	Bma-plc-3	A0A5S6PGW0	A0A1P6C5L9	Bm2256, isoform f.	Phosphoinositide phospholipase C.	0.425
A0A5S6PGW0	Bma-ptp-2	A0A5S6PGW0	A0A0H5S7P5	Bm2256, isoform f.	BMA-PTP-2.	0.409
A0A5S6PGW0	Bma-sta-1	A0A5S6PGW0	A0A1P6C8Z5	Bm2256, isoform f.	Signal transducer and activator of transcription.	0.489
A0A5S6PGW0	bma-ced-2	A0A5S6PGW0	A0A0K0JNG9	Bm2256, isoform f.	BMA-CED-2, isoform a; BMA-CED-2, isoform b.	0.435
A0A5S6PGW0	bma-ist-1	A0A5S6PGW0	A0A0K0J824	Bm2256, isoform f.	BMA-IST-1.	0.450
A0A5S6PGW0	bma-let-23	A0A5S6PGW0	A0A0I9N7Q7	Bm2256, isoform f.	Receptor protein-tyrosine kinase.	0.504
A0A5S6PGW0	bma-shc-1	A0A5S6PGW0	A0A0H5S3Y3	Bm2256, isoform f.	BMA-SHC-1.	0.502
A0A5S6PGX1	A0A5S6PST2	A0A5S6PGX1	A0A5S6PST2	Bm2256, isoform f.	Bm6361.	0.409
A0A5S6PGX1	Bm1_36040	A0A5S6PGX1	A0A0K0JR93	Bm2256, isoform f.	Tyrosine-protein kinase.	0.400
A0A5S6PGX1	Bm1_43090	A0A5S6PGX1	A0A5S6PNC0	Bm2256, isoform f.	BMA-PTP-2.	0.409
A0A5S6PGX1	Bm6361	A0A5S6PGX1	A0A0K0JMU8	Bm2256, isoform f.	Bm6361.	0.409
A0A5S6PGX1	Bma-plc-3	A0A5S6PGX1	A0A1P6C5L9	Bm2256, isoform f.	Phosphoinositide phospholipase C.	0.425
A0A5S6PGX1	Bma-ptp-2	A0A5S6PGX1	A0A0H5S7P5	Bm2256, isoform f.	BMA-PTP-2.	0.409
A0A5S6PGX1	Bma-sta-1	A0A5S6PGX1	A0A1P6C8Z5	Bm2256, isoform f.	Signal transducer and activator of transcription.	0.489
A0A5S6PGX1	bma-ced-2	A0A5S6PGX1	A0A0K0JNG9	Bm2256, isoform f.	BMA-CED-2, isoform a; BMA-CED-2, isoform b.	0.435
A0A5S6PGX1	bma-ist-1	A0A5S6PGX1	A0A0K0J824	Bm2256, isoform f.	BMA-IST-1.	0.450