(181 nodes) Ribosome biogenesis network (Brugia malayi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Bma-lpd-6	BMA-LPD-6. (404 aa)
	Bm4827	Bm4827. (651 aa)
	bma-lsm-6	BMA-LSM-6; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (84 aa)
	Bm1_49205	Bm5039. (378 aa)
	Bm1_41715	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (782 aa)
	bma-mac-1	BMA-MAC-1. (742 aa)
	bma-rpl-5	BMA-RPL-5. (295 aa)
	Bm2820	Bm2820. (377 aa)
	Bm8667	Bm8667, isoform a; Bm8667, isoform b. (992 aa)
	bma-rpl-7	BMA-RPL-7. (249 aa)
	bma-zhit-3	BMA-ZHIT-3. (497 aa)
	Bma-eef-1B.2	BMA-EEF-1B.2, isoform a; BMA-EEF-1B.2, isoform b; Belongs to the EF-1-beta/EF-1-delta family. (300 aa)
	Bm1_39105	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (236 aa)
	Bm1_41325	Bm13985. (378 aa)
	bma-nifk-1	Bm5527. (205 aa)
	Bm1_34560	Bm10503. (187 aa)
	bma-krr-1	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (350 aa)
	bma-mtr-4	Bm13791. (1052 aa)
	Bm1_12160	Bm4544. (528 aa)
	bma-exos-4.1	BMA-EXOS-4.1. (249 aa)
	bma-rha-2	BMA-RHA-2. (1154 aa)
	Bm1_15635	Bm13867. (278 aa)
	bma-abce-1	BMA-ABCE-1. (610 aa)
	Bm1_37955	Bm9652. (595 aa)
	Bma-tag-151	BMA-TAG-151. (776 aa)
	Bm6950	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (122 aa)
	Bm1_15540	Bm3645. (721 aa)
	bma-xpo-1	BMA-XPO-1. (1080 aa)
	Bm1_10910	Bm3450. (825 aa)
	bma-nsun-4	Bm6493; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (465 aa)
	bma-rrbs-1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (338 aa)
	Bma-lin-23	BMA-LIN-23. (625 aa)
	Bma-cku-80	BMA-CKU-80. (610 aa)
	Bma-exos-7	BMA-EXOS-7. (306 aa)
	Bm1_08400	Bm7937. (375 aa)
	Bm4703	Bm4703. (452 aa)
	Bm1_54155	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (306 aa)
	bma-exos-2	BMA-EXOS-2, isoform b; BMA-EXOS-2, isoform c. (295 aa)
	Bm1_41705	Bm13808. (124 aa)
	Bm1_06985	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (786 aa)
	bma-lpd-7	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (525 aa)
	Bm1_27550	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (501 aa)
	Bm1_47230	Bm14005. (341 aa)
	Bm14020	Bm14020. (259 aa)
	bma-rps-8	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
	Bm1_27835	Bm14042; Belongs to the universal ribosomal protein uS7 family. (214 aa)
	Bm1_18840	Bm14060. (150 aa)
	bma-rps-28	BMA-RPS-28. (66 aa)
	bma-nola-3.1	BMA-NOLA-3. (64 aa)
	Bm2125	Bm2125, isoform a. (280 aa)
	Bm1_49685	Bm2213. (175 aa)
	Bm2285	Bm2285. (301 aa)
	Bm1_20805	Bm2408. (389 aa)
	Bm1_35975	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
	Bm1_12395	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (219 aa)
	Bm3269	Bm3269. (175 aa)
	bma-rpl-33.1	Bm3270. (124 aa)
	Bm3356	Bm3356. (928 aa)
	Bm3707	Bm3707. (198 aa)
	Bm1_51345	Bm4311. (459 aa)
	Bma-byn-1	BMA-BYN-1. (438 aa)
	Bm4869	Bm4869. (593 aa)
	Bm4979	Bm4979. (914 aa)
	Bma-pro-1	BMA-PRO-1. (449 aa)
	Bm1_09155	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (364 aa)
	A0A0K0JJN8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (307 aa)
	A0A0K0JJN9	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (641 aa)
	Bm5857	Bm5857. (439 aa)
	Bm1_48555	Bm5947, isoform a. (411 aa)
	bma-sbds-1	BMA-SBDS-1. (253 aa)
	Bm1_12685	Bm6238. (440 aa)
	Bm1_14340	Bm6338. (564 aa)
	Bm1_21735	Bm6341. (265 aa)
	Bm6449	Bm6449. (232 aa)
	Bm1_23940	Bm6511. (561 aa)
	Bm1_09460	Bm6636. (381 aa)
	Bm6750	Bm6750. (781 aa)
	bma-nsun-5	Bm6754; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (434 aa)
	Bm1_19895	BMA-RIOK-2. (490 aa)
	Bm1_11590	Bm7388. (309 aa)
	Bm1_28555	Bm7473. (448 aa)
	Bm8127	Bm8127. (429 aa)
	Bm1_23420	Bm9353. (228 aa)
	Bm1_14190	Bm9476. (626 aa)
	bma-drsh-1	BMA-DRSH-1, isoform c; BMA-DRSH-1, isoform h. (1280 aa)
	Bma-rps-21	40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (84 aa)
	Bma-abcf-2	BMA-ABCF-2, isoform a. (634 aa)
	Bm13693	Bm13693, isoform a. (432 aa)
	Bm1_49315	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (493 aa)
	Bm14034	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (292 aa)
	Bm14055	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (129 aa)
	Bm1_25650	Bm14022. (176 aa)
	Bm8797	Bm8797, isoform b. (188 aa)
	Bm3300	Bm3300, isoform h. (116 aa)
	Bm1_44250	Bm4353, isoform c. (659 aa)
	bma-rps-25	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (126 aa)
	Bma-eri-1	BMA-ERI-1, isoform d. (391 aa)
	Bm1_54890	Bm5954, isoform f; Bm5954, isoform g. (870 aa)
	Bm6789	Bm6789, isoform h. (947 aa)
	Bm6740	Bm6740, isoform a. (739 aa)
	Bm6948	Bm6948, isoform c. (232 aa)
	Bm1_44720	Bm13952. (452 aa)
	Bm1_16165	Bm9239, isoform b. (265 aa)
	bma-rps-14	BMA-RPS-14, isoform b; Ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (151 aa)
	A0A5S6P792	RNA pseudouridylate synthase family protein. (450 aa)
	A0A5S6P7S8	Bm10673. (308 aa)
	A0A5S6P9J4	Bm12943. (1368 aa)
	A0A5S6P9K7	Bm12943. (1364 aa)
	A0A5S6PAR1	Bm13865, isoform a. (902 aa)
	Bm1_31670	Bm13982. (292 aa)
	A0A5S6PCJ3	Uncharacterized protein. (148 aa)
	A0A5S6PCQ0	Uncharacterized protein. (138 aa)
	Bm1_10080	Uncharacterized protein. (112 aa)
	A0A5S6PD87	Bm1733, isoform a. (406 aa)
	A0A5S6PDP9	Uncharacterized protein. (220 aa)
	Bm1_47815	Uncharacterized protein. (254 aa)
	A0A5S6PE35	Uncharacterized protein. (95 aa)
	A0A5S6PF34	Uncharacterized protein. (77 aa)
	A0A5S6PFD7	Uncharacterized protein. (181 aa)
	A0A5S6PFN7	Uncharacterized protein. (286 aa)
	Bm1_22410	RNA helicase. (547 aa)
	A0A5S6PGZ9	Bm2285. (337 aa)
	A0A5S6PJR6	Bm3300, isoform h. (204 aa)
	Bm1_09160	Bm3435. (360 aa)
	A0A5S6PKS5	Bm3707. (182 aa)
	A0A5S6PL84	Bm3782. (462 aa)
	Bm1_13250	BMA-EXOS-7. (308 aa)
	A0A5S6PLC9	Bm3782. (445 aa)
	Bm1_43415	Uncharacterized protein. (334 aa)
	A0A5S6PNH6	Bm4869. (598 aa)
	A0A5S6PNS3	BMA-LIN-23. (620 aa)
	A0A5S6PQ59	BMA-PRO-1. (430 aa)
	Bm1_15070	Bm5499. (459 aa)
	A0A5S6PS42	Bm6359. (780 aa)
	A0A5S6PS76	Bm6359. (773 aa)
	A0A5S6PSF7	Uncharacterized protein. (718 aa)
	A0A5S6PSH4	Bm6449. (157 aa)
	A0A5S6PSI4	Uncharacterized protein. (716 aa)
	A0A5S6PSR4	Uncharacterized protein. (772 aa)
	A0A5S6PSV5	Uncharacterized protein. (774 aa)
	Bm1_08360	Uncharacterized protein. (206 aa)
	A0A5S6PTH7	Bm6750. (751 aa)
	Bm1_00695	Nucleolar protein 6. (1410 aa)
	Bm1_54420	BMA-CKU-80. (605 aa)
	bma-pinn-4	Peptidyl-prolyl cis-trans isomerase. (126 aa)
	Bm1_36175	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (642 aa)
	Bm1_41245	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (301 aa)
	Bm1_47965	Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (433 aa)
	bma-frg-1	FRG1 protein homolog, putative. (273 aa)
	Bm1_57380	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (535 aa)
	bma-rla-0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (320 aa)
	Bm1_16265	Bm13686. (482 aa)
	Bm1_07190	BMA-EXOS-8. (276 aa)
	Bm10673	Bm10673. (350 aa)
	Bm1_17915	Protein MAK16 homolog; Belongs to the MAK16 family. (328 aa)
	bma-rps-7	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (197 aa)
	Bm1_14425	Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (424 aa)
	Bm2876	Bm2876, isoform b; Bm2876, isoform d. (408 aa)
	bma-nol-58	BMA-NOL-5, isoform b. (486 aa)
	bma-rps-15	BMA-RPS-15; Belongs to the universal ribosomal protein uS19 family. (151 aa)
	Bm1_48075	Bm12847. (170 aa)
	bma-eif-6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa)
	bma-rpl-24.2	Bm13894. (161 aa)
	Bm1_23025	Bm14814. (423 aa)
	Bma-ddx-15	BMA-DDX-15, isoform b; BMA-DDX-15, isoform e. (742 aa)
	bma-rpl-1	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family. (216 aa)
	Bma-zhit-2	BMA-ZHIT-2. (179 aa)
	bma-mrpl-20	BMA-MRPL-20. (188 aa)
	bma-rpl-10.2	Bm13774, isoform a. (214 aa)
	bma-nol-16	Bm7439, isoform b; Bm7439, isoform d. (197 aa)
	bma-rpl-33.2	Bm408. (123 aa)
	Bm1_16465	Bm7533. (527 aa)
	Bm14713	Bm14713. (168 aa)
	Bm296	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (151 aa)
	Bm1_04800	Bm4425, isoform b; Belongs to the universal ribosomal protein uL23 family. (164 aa)
	Bm6339	RNA helicase. (801 aa)
	bma-rps-27	BMA-RPS-27. (84 aa)
	bma-rps-16	BMA-RPS-16; Belongs to the universal ribosomal protein uS9 family. (143 aa)
	bma-ncl-1	Bm7423, isoform b. (807 aa)
	Bm6577	Bm6577. (1313 aa)
	bma-rps-19.1	Bm12929. (150 aa)

Your Current Organism:

Brugia malayi

NCBI taxonomy Id: 6279
Other names: B. malayi, agent of lymphatic filariasis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0K0JJN8	A0A0K0JJN9	A0A0K0JJN8	A0A0K0JJN9	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.958
A0A0K0JJN8	A0A5S6P7S8	A0A0K0JJN8	A0A5S6P7S8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm10673.	0.669
A0A0K0JJN8	A0A5S6PAR1	A0A0K0JJN8	A0A5S6PAR1	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm13865, isoform a.	0.581
A0A0K0JJN8	A0A5S6PCQ0	A0A0K0JJN8	A0A5S6PCQ0	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.580
A0A0K0JJN8	A0A5S6PD87	A0A0K0JJN8	A0A5S6PD87	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm1733, isoform a.	0.551
A0A0K0JJN8	A0A5S6PF34	A0A0K0JJN8	A0A5S6PF34	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.447
A0A0K0JJN8	A0A5S6PFD7	A0A0K0JJN8	A0A5S6PFD7	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.665
A0A0K0JJN8	A0A5S6PFN7	A0A0K0JJN8	A0A5S6PFN7	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.575
A0A0K0JJN8	A0A5S6PGZ9	A0A0K0JJN8	A0A5S6PGZ9	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm2285.	0.779
A0A0K0JJN8	A0A5S6PJR6	A0A0K0JJN8	A0A5S6PJR6	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm3300, isoform h.	0.633
A0A0K0JJN8	A0A5S6PKS5	A0A0K0JJN8	A0A5S6PKS5	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm3707.	0.476
A0A0K0JJN8	A0A5S6PNH6	A0A0K0JJN8	A0A5S6PNH6	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm4869.	0.415
A0A0K0JJN8	A0A5S6PSF7	A0A0K0JJN8	A0A5S6PSF7	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.610
A0A0K0JJN8	A0A5S6PSH4	A0A0K0JJN8	A0A5S6PSH4	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm6449.	0.646
A0A0K0JJN8	A0A5S6PSI4	A0A0K0JJN8	A0A5S6PSI4	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.610
A0A0K0JJN8	A0A5S6PSR4	A0A0K0JJN8	A0A5S6PSR4	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.610
A0A0K0JJN8	A0A5S6PSV5	A0A0K0JJN8	A0A5S6PSV5	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.610
A0A0K0JJN8	A0A5S6PTH7	A0A0K0JJN8	A0A5S6PTH7	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm6750.	0.602
A0A0K0JJN8	Bm10673	A0A0K0JJN8	A0A0K0IP30	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm10673.	0.669
A0A0K0JJN8	Bm13693	A0A0K0JJN8	A0A1P6BLL2	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Bm13693, isoform a.	0.818