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guaB guaB ribA ribA panD panD fhs fhs RibF RibF guaA guaA PurF PurF cvpA cvpA folC folC folB folB pyrF pyrF tmk tmk pyrE pyrE pyrC pyrC coaE coaE ribE ribE folP folP EEP68967.1 EEP68967.1 EEP68970.1 EEP68970.1 folD folD glyA glyA gmk gmk pyrG pyrG purC purC panB panB apt apt purE purE folA folA pdxJ pdxJ NrdB NrdB purA purA coaBC coaBC pyrD pyrD surE surE purL purL NrdA NrdA folK folK ribH ribH nusB nusB dut dut pyrI pyrI pyrB pyrB nrdD nrdD dcd dcd purM purM purH purH frp frp EEP67543.1 EEP67543.1 thyA thyA purN purN EEP67610.1 EEP67610.1 panC panC purB purB adk adk purK purK ribB ribB coaX coaX pdxH pdxH purD purD aphA aphA ribD ribD coaD coaD coaBC-2 coaBC-2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (235 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa)
fhsKEGG: ngo:NGO0062 2.9e-237 putative formate--tetrahydrofolate ligase K01938; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
RibFKEGG: nma:NMA0621 3.1e-34 ribF; putative riboflavin kinase/FMN adenylyltransferase K00861:K00953. (122 aa)
guaAGMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. (549 aa)
PurFKEGG: nme:NMB0690 5.9e-127 amidophosphoribosyltransferase K00764; Psort location: Cytoplasmic, score: 8.96. (346 aa)
cvpACvpA family protein; KEGG: cal:orf19.575 0.0051 HYR5; similar to HYR1 K01186; Psort location: CytoplasmicMembrane, score: 9.46. (259 aa)
folCBifunctional protein FolC; KEGG: nme:NMB0693 5.0e-130 folylpolyglutamate synthase / dihydrofolate synthase K01927:K01930; Psort location: CytoplasmicMembrane, score: 8.02. (803 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (116 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (249 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa)
pyrCDihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa)
ribEKEGG: nma:NMA1416 6.3e-75 ribC; putative riboflavin synthase alpha subunit K00793. (205 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa)
EEP68967.1Oxidoreductase NAD-binding domain protein; KEGG: tbd:Tbd_2563 2.1e-74 NAD(P)H-flavin reductase K00523. (340 aa)
EEP68970.1Dihydroorotate dehydrogenase 1A; Catalyzes the conversion of dihydroorotate to orotate. (297 aa)
folDTetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (606 aa)
purCKEGG: nma:NMA0968 5.2e-119 purC; putative phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; Belongs to the SAICAR synthetase family. (325 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (262 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (235 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)
pdxJPyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa)
NrdBRibonucleoside-diphosphate reductase, beta subunit; KEGG: ngo:NGO0615 6.8e-181 putative ribonucleoside diphosphate reductase I beta chain K00526; Psort location: Cytoplasmic, score: 8.96. (384 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
coaBCPhosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (494 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (333 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (252 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1297 aa)
NrdARibonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (757 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; KEGG: ngo:NGO0323 8.3e-41 HppK K00950. (159 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (152 aa)
nusBTranscription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (145 aa)
dutdUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa)
pyrIAspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa)
pyrBKEGG: nma:NMA0168 1.1e-132 pyrB; aspartate carbamoyltransferase catalytic chain K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
nrdDKEGG: ilo:IL0188 1.0e-255 oxygen-sensitive ribonucleoside-triphosphate reductase K00527; Psort location: Cytoplasmic, score: 8.96. (593 aa)
dcddCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa)
purMKEGG: nme:NMB1252 2.8e-159 phosphoribosylformylglycinamidine cyclo-ligase K01933. (345 aa)
purHKEGG: nme:NMB0983 2.1e-241 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602:K01492; Psort location: Cytoplasmic, score: 8.96. (525 aa)
frpKEGG: vpa:VPA1601 4.0e-57 NADPH-flavin oxidoreductase; Belongs to the flavin oxidoreductase frp family. (245 aa)
EEP67543.1Asparaginase; KEGG: nme:NMB1688 1.6e-76 L-asparaginase I K01424; Psort location: Cytoplasmic, score: 9.26. (332 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (209 aa)
EEP67610.1Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain protein; KEGG: nma:NMA0168 8.7e-46 pyrB; aspartate carbamoyltransferase catalytic chain K00609; Psort location: Cytoplasmic, score: 8.96; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (115 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (277 aa)
purBAdenylosuccinate lyase; KEGG: nma:NMA2203 2.8e-198 purB; adenylosuccinate lyase K01756; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (379 aa)
ribB3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (389 aa)
coaXbiotin--[acetyl-CoA-carboxylase] ligase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (569 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (210 aa)
purDKEGG: nma:NMA0238 8.8e-188 purD; phosphoribosylamine--glycine ligase K01945; Belongs to the GARS family. (423 aa)
aphAHAD phosphatase, family IIIB; KEGG: sag:SAG0635 2.1e-60 acid phosphatase, class B K03788. (242 aa)
ribDRiboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (359 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (170 aa)
coaBC-2Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (395 aa)
Your Current Organism:
Kingella oralis
NCBI taxonomy Id: 629741
Other names: K. oralis ATCC 51147, Kingella oralis ATCC 51147, Kingella oralis str. ATCC 51147, Kingella oralis strain ATCC 51147
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