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| | EEP69557.1 | RNA polymerase sigma-70 factor, TIGR02943 family; KEGG: reh:H16_B2413 1.2e-32 rpoE6; DNA-directed RNA polymerase sigma subunit (RpoE,sigma24) K00960; Psort location: Cytoplasmic, score: 8.96; Belongs to the sigma-70 factor family. ECF subfamily. (196 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa) |
| | hemL | Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: nma:NMA0592 1.4e-187 hemL; glutamate-1-semialdehyde 2,1-aminomutase K01845. (441 aa) |
| | nusG | Transcription termination/antitermination factor NusG; Participates in transcription elongation, termination and antitermination. (179 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1398 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1408 aa) |
| | EEP69611.1 | Hypothetical protein. (133 aa) |
| | EEP69620.1 | KEGG: saa:SAUSA300_2159 6.6e-96 aldo/keto reductase family protein K03378; Psort location: Cytoplasmic, score: 8.96. (282 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (235 aa) |
| | EEP68332.1 | Chorismate binding enzyme; KEGG: nma:NMA1247 6.6e-64 trpE; anthranilate synthase component I K01657; Psort location: Cytoplasmic, score: 8.96. (156 aa) |
| | hemB | Porphobilinogen synthase; KEGG: nme:NMB0801 1.2e-144 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 8.96; Belongs to the ALAD family. (335 aa) |
| | DnaE | KEGG: nme:NMB1827 0. DNA polymerase III, alpha subunit K02337; Psort location: Cytoplasmic, score: 9.97. (1156 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (206 aa) |
| | nusA | Transcription termination factor NusA; Participates in both transcription termination and antitermination. (500 aa) |
| | nadE | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (263 aa) |
| | FdhD | KEGG: eci:UTI89_C4482 2.0e-23 fdhD; formate dehydrogenase-N influencing protein K02379; Psort location: Cytoplasmic, score: 9.26. (101 aa) |
| | FdnG | Formate dehydrogenase, alpha subunit; KEGG: cvi:CV3839 0. fdnG; formate dehydrogenase K00123; Psort location: Periplasmic, score: 9.44; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1024 aa) |
| | RibF | KEGG: nma:NMA0621 3.1e-34 ribF; putative riboflavin kinase/FMN adenylyltransferase K00861:K00953. (122 aa) |
| | prs | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (342 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (398 aa) |
| | EEP68574.1 | FAD binding domain protein; KEGG: reu:Reut_B4589 3.0e-171 L-aspartate oxidase K00278; Psort location: Periplasmic, score: 9.44. (548 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (641 aa) |
| | EEP68599.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (407 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (323 aa) |
| | moaB | KEGG: hpa:HPAG1_0784 3.4e-12 molybdopterin biosynthesis protein. (239 aa) |
| | EEP68604.1 | Hypothetical protein. (190 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C. (164 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. (549 aa) |
| | queH | Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (230 aa) |
| | dnaX | KEGG: nme:NMB1443 1.3e-179 dnaX; DNA polymerase III subunits gamma and tau K00961. (820 aa) |
| | PurF | KEGG: nme:NMB0690 5.9e-127 amidophosphoribosyltransferase K00764; Psort location: Cytoplasmic, score: 8.96. (346 aa) |
| | folC | Bifunctional protein FolC; KEGG: nme:NMB0693 5.0e-130 folylpolyglutamate synthase / dihydrofolate synthase K01927:K01930; Psort location: CytoplasmicMembrane, score: 8.02. (803 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (116 aa) |
| | nadK | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (340 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (249 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | hemN | Coproporphyrinogen dehydrogenase; KEGG: ngo:NGO1580 1.5e-192 hemN; HemN K02495; Psort location: Cytoplasmic, score: 9.97; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (467 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa) |
| | PncC | Competence/damage-inducible domain protein CinA; Belongs to the CinA family. (158 aa) |
| | EEP68913.1 | BolA-like protein; Belongs to the BolA/IbaG family. (89 aa) |
| | ribE | KEGG: nma:NMA1416 6.3e-75 ribC; putative riboflavin synthase alpha subunit K00793. (205 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa) |
| | EEP68970.1 | Dihydroorotate dehydrogenase 1A; Catalyzes the conversion of dihydroorotate to orotate. (297 aa) |
| | serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (366 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (371 aa) |
| | rpoH | Alternative sigma factor RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (290 aa) |
| | hemD | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (241 aa) |
| | EEP69050.1 | Putative hemY protein. (397 aa) |
| | dnaB | KEGG: cvi:CV2502 4.2e-69 dnaB; replicative DNA helicase K02314; Psort location: Cytoplasmic, score: 8.96. (454 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (69 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (606 aa) |
| | purC | KEGG: nma:NMA0968 5.2e-119 purC; putative phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; Belongs to the SAICAR synthetase family. (325 aa) |
| | rfbD | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (293 aa) |
| | EEP69191.1 | ACT domain protein; KEGG: spk:MGAS9429_Spy1852 2.4e-06 sdhB; L-serinedehydratase beta subunit K01752; Belongs to the UPF0237 family. (90 aa) |
| | NudB | Hydrolase, NUDIX family; KEGG: nme:NMB0642 1.8e-36 dATP pyrophosphohydrolase K08310. (182 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (235 aa) |
| | priB | Single-strand binding family protein; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (98 aa) |
| | EEP69228.1 | Tat pathway signal sequence domain protein; KEGG: rba:RB1639 5.8e-49 similar to monooxygenase K00492. (619 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (339 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa) |
| | trpF | KEGG: nma:NMA0890 2.6e-62 trpF; putative N-(5'-phosphoribosyl)anthranilate isomerase K01817; Psort location: Cytoplasmic, score: 8.96; Belongs to the TrpF family. (256 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa) |
| | NrdB | Ribonucleoside-diphosphate reductase, beta subunit; KEGG: ngo:NGO0615 6.8e-181 putative ribonucleoside diphosphate reductase I beta chain K00526; Psort location: Cytoplasmic, score: 8.96. (384 aa) |
| | dinB | Putative DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (360 aa) |
| | EEP69381.1 | Putative ACR, COG1678; Belongs to the UPF0301 (AlgH) family. (182 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (373 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (494 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (333 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (180 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1297 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | holA | DNA polymerase III, delta subunit; KEGG: ngo:NGO0283 5.1e-112 putative DNA polymerase K02340. (336 aa) |
| | dnaB-2 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa) |
| | glmU | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (455 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (475 aa) |
| | rpoA | KEGG: nme:NMB0168 1.9e-121 DNA-directed RNA polymerase, alpha subunit K03040; Psort location: Cytoplasmic, score: 9.97. (278 aa) |
| | EEP67282.1 | Isochorismatase family protein; KEGG: nma:NMA0244 2.1e-76 pncA; putative nicotinamidase K01440. (215 aa) |
| | dnaN | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa) |
| | EEP67313.1 | Putative TIGR00701 family protein; Psort location: CytoplasmicMembrane, score: 9.46. (136 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; KEGG: ngo:NGO0323 8.3e-41 HppK K00950. (159 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (152 aa) |
| | nusB | Transcription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (145 aa) |
| | dut | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa) |
| | EEP67354.1 | KEGG: cvi:CV0499 1.1e-29 probable 5-formyltetrahydrofolate cyclo-ligase K01934; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (216 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | pyrB | KEGG: nma:NMA0168 1.1e-132 pyrB; aspartate carbamoyltransferase catalytic chain K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | dcd | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | purM | KEGG: nme:NMB1252 2.8e-159 phosphoribosylformylglycinamidine cyclo-ligase K01933. (345 aa) |
| | purH | KEGG: nme:NMB0983 2.1e-241 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602:K01492; Psort location: Cytoplasmic, score: 8.96. (525 aa) |
| | EEP67515.1 | Hypothetical protein. (287 aa) |
| | EEP67527.1 | Hypothetical protein; KEGG: pfo:Pfl_1206 2.4e-05 ABC transporter-like K02028. (408 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (321 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (209 aa) |
| | EEP67610.1 | Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain protein; KEGG: nma:NMA0168 8.7e-46 pyrB; aspartate carbamoyltransferase catalytic chain K00609; Psort location: Cytoplasmic, score: 8.96; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (115 aa) |
| | trpC | KEGG: nme:NMB0275 3.7e-93 indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 8.96; Belongs to the TrpC family. (260 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (316 aa) |
| | holB | KEGG: ngo:NGO0347 1.2e-101 putative DNA polymerase III, delta' subunit K02341. (326 aa) |
| | EEP67746.1 | Zinc-binding domain of primase-helicase; KEGG: sty:STY4832 1.0e-20 Bacteriophage P4 DNA primase. (180 aa) |
| | EEP67747.1 | Hypothetical protein. (165 aa) |
| | EEP67751.1 | Hypothetical protein. (571 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (353 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (594 aa) |
| | rpoN | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (453 aa) |
| | purB | Adenylosuccinate lyase; KEGG: nma:NMA2203 2.8e-198 purB; adenylosuccinate lyase K01756; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | EEP67080.1 | KEGG: nme:NMB1451 3.7e-86 DNA polymerase III, epsilon subunit K02342; Psort location: Cytoplasmic, score: 8.96. (464 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (260 aa) |
| | EEP67000.1 | Acetyltransferase, GNAT family; KEGG: ctc:CTC01168 1.2e-25 acetyltransferase K02348; Psort location: Cytoplasmic, score: 8.96. (147 aa) |
| | pyrH | UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa) |
| | ribB | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (389 aa) |
| | rfaD | ADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (333 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (379 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (253 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (332 aa) |
| | EEP68218.1 | ThiF family protein; KEGG: rme:Rmet_0249 2.9e-63 UBA/ThiF-type NAD/FAD binding fold. (247 aa) |
| | folE | GTP cyclohydrolase folE2; Converts GTP to 7,8-dihydroneopterin triphosphate. (254 aa) |
| | thiL | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa) |
| | EEP68130.1 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (392 aa) |
| | cmk | Cytidylate kinase; KEGG: nme:NMB1300 2.2e-72 cytidylate kinase K00945. (220 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa) |
| | EEP68017.1 | Oxidoreductase, aldo/keto reductase family protein; KEGG: cgl:NCgl1003 5.5e-76 cgl1048; aldo/keto reductase K03378. (306 aa) |
| | rpoD | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (654 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (359 aa) |
| | EEP68005.1 | CBS domain protein; KEGG: eci:UTI89_C0656 9.2e-58 ybeX; putative transport protein K06189; Psort location: Cytoplasmic, score: 8.96. (289 aa) |
| | EEP67971.1 | Hypothetical protein; KEGG: mpa:MAP1956 9.5e-10 sucB; dihydrolipoamide succinyltransferase K00658. (294 aa) |
| | EEP67945.1 | Tat pathway signal sequence domain protein; KEGG: rle:RL1457 0.0091 putative electron transfer flavoprotein-ubiquinone oxidoreductase K00311. (611 aa) |
| | EEP66524.1 | Initiator RepB protein. (337 aa) |
| | coaBC-2 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (395 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (170 aa) |
| | EEP66731.1 | Purine/pyrimidine phosphoribosyltransferase family protein; KEGG: sso:SSO2424 9.0e-12 gpt-2; purine phosphoribosyltransferase (gpt-2); Psort location: Cytoplasmic, score: 8.96. (179 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (359 aa) |
| | queC | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (217 aa) |
| | EEP66694.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (119 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (145 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (465 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (515 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (182 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (166 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (78 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (288 aa) |
| | EEP66571.1 | Putative membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (226 aa) |
| | queF | preQ(1) synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (157 aa) |
| | akr5f | Organophosphate reductase; KEGG: eci:UTI89_C0320 2.2e-111 2,5-diketo-D-gluconic acid reductase A K00100. (284 aa) |
| | purD | KEGG: nma:NMA0238 8.8e-188 purD; phosphoribosylamine--glycine ligase K01945; Belongs to the GARS family. (423 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (210 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (422 aa) |
| | EEP66852.1 | Hypothetical protein. (136 aa) |
| | polA | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (930 aa) |
| | coaX | biotin--[acetyl-CoA-carboxylase] ligase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (569 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (244 aa) |
| | serS | serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | EEP67108.1 | Putative molybdopterin converting factor, subunit 1. (78 aa) |
| | moaE | Molybdopterin converting factor, subunit 2. (146 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (771 aa) |
