node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEP68599.1 | moaA | GCWU000324_00502 | GCWU000324_00503 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | 0.965 |
EEP68599.1 | moaB | GCWU000324_00502 | GCWU000324_00504 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. | KEGG: hpa:HPAG1_0784 3.4e-12 molybdopterin biosynthesis protein. | 0.990 |
EEP68599.1 | moaC | GCWU000324_00502 | GCWU000324_00511 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. | Molybdenum cofactor biosynthesis protein C. | 0.928 |
EEP68599.1 | moaE | GCWU000324_00502 | GCWU000324_02679 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. | Molybdopterin converting factor, subunit 2. | 0.931 |
NudB | folE | GCWU000324_01112 | GCWU000324_02445 | Hydrolase, NUDIX family; KEGG: nme:NMB0642 1.8e-36 dATP pyrophosphohydrolase K08310. | GTP cyclohydrolase folE2; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.913 |
folA | folB | GCWU000324_01166 | GCWU000324_00641 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.424 |
folA | folC | GCWU000324_01166 | GCWU000324_00638 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional protein FolC; KEGG: nme:NMB0693 5.0e-130 folylpolyglutamate synthase / dihydrofolate synthase K01927:K01930; Psort location: CytoplasmicMembrane, score: 8.02. | 0.935 |
folA | folK | GCWU000324_01166 | GCWU000324_01594 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; KEGG: ngo:NGO0323 8.3e-41 HppK K00950. | 0.415 |
folA | folP | GCWU000324_01166 | GCWU000324_00861 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.626 |
folB | folA | GCWU000324_00641 | GCWU000324_01166 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.424 |
folB | folC | GCWU000324_00641 | GCWU000324_00638 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Bifunctional protein FolC; KEGG: nme:NMB0693 5.0e-130 folylpolyglutamate synthase / dihydrofolate synthase K01927:K01930; Psort location: CytoplasmicMembrane, score: 8.02. | 0.818 |
folB | folK | GCWU000324_00641 | GCWU000324_01594 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; KEGG: ngo:NGO0323 8.3e-41 HppK K00950. | 0.995 |
folB | folP | GCWU000324_00641 | GCWU000324_00861 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.995 |
folB | ribB | GCWU000324_00641 | GCWU000324_02563 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.579 |
folC | folA | GCWU000324_00638 | GCWU000324_01166 | Bifunctional protein FolC; KEGG: nme:NMB0693 5.0e-130 folylpolyglutamate synthase / dihydrofolate synthase K01927:K01930; Psort location: CytoplasmicMembrane, score: 8.02. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.935 |
folC | folB | GCWU000324_00638 | GCWU000324_00641 | Bifunctional protein FolC; KEGG: nme:NMB0693 5.0e-130 folylpolyglutamate synthase / dihydrofolate synthase K01927:K01930; Psort location: CytoplasmicMembrane, score: 8.02. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.818 |
folC | folK | GCWU000324_00638 | GCWU000324_01594 | Bifunctional protein FolC; KEGG: nme:NMB0693 5.0e-130 folylpolyglutamate synthase / dihydrofolate synthase K01927:K01930; Psort location: CytoplasmicMembrane, score: 8.02. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; KEGG: ngo:NGO0323 8.3e-41 HppK K00950. | 0.690 |
folC | folP | GCWU000324_00638 | GCWU000324_00861 | Bifunctional protein FolC; KEGG: nme:NMB0693 5.0e-130 folylpolyglutamate synthase / dihydrofolate synthase K01927:K01930; Psort location: CytoplasmicMembrane, score: 8.02. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.987 |
folC | ribB | GCWU000324_00638 | GCWU000324_02563 | Bifunctional protein FolC; KEGG: nme:NMB0693 5.0e-130 folylpolyglutamate synthase / dihydrofolate synthase K01927:K01930; Psort location: CytoplasmicMembrane, score: 8.02. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.574 |
folE | NudB | GCWU000324_02445 | GCWU000324_01112 | GTP cyclohydrolase folE2; Converts GTP to 7,8-dihydroneopterin triphosphate. | Hydrolase, NUDIX family; KEGG: nme:NMB0642 1.8e-36 dATP pyrophosphohydrolase K08310. | 0.913 |