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nadC nadC nadR nadR deoD deoD nrdD nrdD nrdG nrdG pncB pncB cpdB cpdB CH53_1552 CH53_1552 dut dut sth sth cya cya udp udp nudC nudC cpdA cpdA ygdH ygdH ppnP ppnP adk adk gsk gsk ushA ushA nadD nadD CH53_3129 CH53_3129 yfkN yfkN nadA nadA pnuC pnuC cyaB cyaB cdd cdd udk udk dcd dcd nrdA nrdA nrdB nrdB ycbX_2 ycbX_2 yfaY yfaY CH53_3850 CH53_3850 yfbR yfbR tdk tdk add add amn amn yjjG yjjG pntB pntB pntA pntA CH53_4089 CH53_4089 cobB-2 cobB-2 upp upp ndk ndk nadE nadE nadB nadB ppnK ppnK nrdH nrdH nrdI nrdI nrdE nrdE nrdF nrdF ygaD ygaD rpoS rpoS nlpD_1 nlpD_1 pcm pcm surE surE truD truD pyrG pyrG mazG mazG relA relA rumA-2 rumA-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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nadCnadC: nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. (302 aa)
nadRTrifunctional NAD biosynthesis/regulator protein NadR. (424 aa)
deoDdeoD: purine nucleoside phosphorylase. (239 aa)
nrdDnrdD: anaerobic ribonucleoside-triphosphate reductase. (708 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (128 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (401 aa)
cpdBcycNucDiestase: 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. (655 aa)
CH53_1552HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. (226 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa)
sthPyridine nucleotide-disulfide oxidoreductase family protein; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (466 aa)
cyaAdenylate cyclase, class-I family protein. (848 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa)
nudCNADH pyrophosphatase-like rudimentary NUDIX domain protein; Belongs to the Nudix hydrolase family. NudC subfamily. (259 aa)
cpdACalcineurin-like phosphoesterase family protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)
ygdHHypothetical protein. (454 aa)
ppnPHypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (95 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
gskInosine-guanosine kinase. (434 aa)
ushAProtein UshA; Belongs to the 5'-nucleotidase family. (550 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (222 aa)
CH53_3129cAMP phosphodiesterases class-II family protein. (358 aa)
yfkNHypothetical protein; 5'-nucleotidase, C-terminal domain protein; Belongs to the 5'-nucleotidase family. (632 aa)
nadAQuinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (353 aa)
pnuCNMN_trans_PnuC: nicotinamide mononucleotide transporter PnuC family protein. (241 aa)
cyaBAdenylate cyclase 2. (179 aa)
cddCytidine and deoxycytidylate deaminase zinc-binding region family protein; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (297 aa)
udkUdk: uridine kinase. (213 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa)
nrdARibonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (761 aa)
nrdBRibonucleoside-diphosphate reductase 1 subunit beta. (376 aa)
ycbX_22Fe-2S iron-sulfur cluster binding domain protein. (85 aa)
yfaYMolyb_syn: molybdenum cofactor synthesis domain protein; Belongs to the CinA family. (397 aa)
CH53_3850Isochorismatase family protein. (216 aa)
yfbRHD domain protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (197 aa)
tdkThymidine kinase family protein. (199 aa)
addAden_deam: adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (332 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (486 aa)
yjjGyjjG/YfnB: noncanonical pyrimidine nucleotidase, YjjG family. (224 aa)
pntBNAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (463 aa)
pntANAD(P)(+) transhydrogenase (AB-specific), alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. (508 aa)
CH53_4089Hypothetical protein. (79 aa)
cobB-2Sir2 family protein; Belongs to the sirtuin family. Class III subfamily. (281 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (142 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (540 aa)
nadBL-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (533 aa)
ppnKATP-NAD kinase family protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (293 aa)
nrdHglrX_NrdH: glutaredoxin-like NrdH family protein. (78 aa)
nrdInrdI protein; Probably involved in ribonucleotide reductase function. (134 aa)
nrdERibonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (693 aa)
nrdFRibonucleotide reductase, small chain family protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (323 aa)
ygaDProtein YgaD; Belongs to the CinA family. (162 aa)
rpoSRNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (332 aa)
nlpD_1lysM domain protein. (321 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (208 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (250 aa)
truDtRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (349 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
mazGNucleoside triphosphate pyrophosphohydrolase. (280 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa)
rumA-223S rRNA (uracil-5-)-methyltransferase RumA; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (443 aa)
Your Current Organism:
Yersinia intermedia
NCBI taxonomy Id: 631
Other names: ATCC 29909, CCUG 11292, CIP 80.28, DSM 18517, JCM 7579, NCTC 11469, Y. intermedia, strain 3953, strain Bottone 48, strain Chester 48
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