STRINGSTRING
secM secM setA setA hspQ hspQ yccT yccT trpR trpR slt slt helD helD CH53_1113 CH53_1113 sxy sxy matP matP CH53_1172 CH53_1172 CH53_1176 CH53_1176 CH53_1264 CH53_1264 bhsA_1 bhsA_1 ydgH_1 ydgH_1 CH53_1315 CH53_1315 ytfJ ytfJ ompF ompF CH53_1321 CH53_1321 CH53_1334 CH53_1334 kefA_1 kefA_1 CH53_1363 CH53_1363 mukB mukB yjdC yjdC mukE mukE mukF mukF smtA smtA CH53_142 CH53_142 CH53_143 CH53_143 yccS_1 yccS_1 tsgA tsgA damX damX igaA igaA CH53_1564 CH53_1564 uspB uspB uspA uspA cdh cdh lolA lolA yiaH yiaH yibL yibL CH53_1694 CH53_1694 CH53_1710 CH53_1710 CH53_1711 CH53_1711 viaA viaA ravA ravA bssS bssS yihD yihD CH53_1890 CH53_1890 zapB zapB CH53_2023 CH53_2023 CH53_2024 CH53_2024 CH53_2025 CH53_2025 CH53_2026 CH53_2026 yhhK yhhK CH53_206 CH53_206 psiE psiE pspG pspG panF panF CH53_2192 CH53_2192 aaeX aaeX yhcQ yhcQ yhcP_2 yhcP_2 yhcB yhcB lpoA lpoA CH53_2581 CH53_2581 zapA zapA CH53_2616 CH53_2616 CH53_263 CH53_263 ygdR ygdR CH53_2716 CH53_2716 rof rof yaeP yaeP tsaA tsaA rcsF rcsF frsA frsA crl crl ycgR ycgR CH53_2813 CH53_2813 pgpA pgpA CH53_2858 CH53_2858 sgrR_2 sgrR_2 hha hha tomB tomB capB capB CH53_3126 CH53_3126 CH53_3150 CH53_3150 ompC2 ompC2 ompX ompX CH53_3304 CH53_3304 ompC ompC yeeX yeeX yfaZ yfaZ uspA_1 uspA_1 CH53_3619 CH53_3619 pgsA pgsA ompD ompD CH53_3759 CH53_3759 ycdX ycdX ycdY ycdY yceB yceB yecM yecM mipA mipA hns hns yciU yciU cls cls yfbU yfbU yciC yciC mdoC mdoC yciN yciN pgpB pgpB bhsA bhsA ydgA ydgA tus tus ynfD ynfD ynfB ynfB yhjH_2 yhjH_2 ydgH ydgH blaSE blaSE CH53_4043 CH53_4043 mliC mliC lpp lpp yfeE yfeE ydjM ydjM CH53_4348 CH53_4348 yobD yobD yiiS yiiS CH53_4418 CH53_4418 lpoB lpoB ycfL ycfL CH53_4423 CH53_4423 yfeY yfeY CH53_567 CH53_567 speG speG CH53_653 CH53_653 CH53_672 CH53_672 CH53_744 CH53_744 yafD yafD CH53_804 CH53_804 ywaD ywaD CH53_985 CH53_985 CH53_989 CH53_989 ampE ampE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
secMSecretion monitor family protein; Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. Belongs to the SecM family. (179 aa)
setASugar efflux transporter A. (389 aa)
hspQHemimethylated DNA binding domain protein; Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress; Belongs to the HspQ family. (105 aa)
yccTHypothetical protein; Belongs to the UPF0319 family. (227 aa)
trpRTrp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. (132 aa)
sltSoluble lytic murein transglycosylase L domain protein. (639 aa)
helDHypothetical protein; uvrD/REP helicase N-terminal domain protein. (684 aa)
CH53_1113Bacterial virulence factor hemolysin family protein. (230 aa)
sxytfoX N-terminal domain protein. (211 aa)
matPOrganizer of macrodomain of Terminus of chromosome family protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. (151 aa)
CH53_1172Hypothetical protein. (160 aa)
CH53_1176Winged helix-turn-helix DNA-binding family protein. (81 aa)
CH53_1264Putative uPF0306 protein YPO3467/y0717/YP_0616; Belongs to the UPF0306 family. (147 aa)
bhsA_1Hypothetical protein. (87 aa)
ydgH_1Hypothetical protein. (87 aa)
CH53_1315Hypothetical protein. (70 aa)
ytfJHypothetical protein. (187 aa)
ompFGram-negative porin family protein. (375 aa)
CH53_1321Hypothetical protein; Opacity-associated A N-terminal motif family protein. (260 aa)
CH53_1334Hypothetical protein. (66 aa)
kefA_1Mechanosensitive ion channel family protein. (1098 aa)
CH53_1363Hypothetical protein. (114 aa)
mukBHypothetical protein; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily. (1485 aa)
yjdCHTH-type transcriptional regulator yjdC. (191 aa)
mukEChromosome partition protein mukE; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF. (242 aa)
mukFChromosome partition protein mukF; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. (440 aa)
smtAProtein smtA; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family. (261 aa)
CH53_142Hypothetical protein. (255 aa)
CH53_143Fructosamine kinase family protein. (297 aa)
yccS_1YCCS_YHJK: integral membrane, YccS/YhfK family protein. (710 aa)
tsgAMajor Facilitator Superfamily protein. (394 aa)
damXSporulation related domain protein; Non-essential cell division protein. (335 aa)
igaAIntracellular growth attenuator IgaA family protein. (708 aa)
CH53_1564Hypothetical protein. (87 aa)
uspBUniversal stress protein B. (111 aa)
uspAUniversal stress protein A. (148 aa)
cdhCDP-diacylglycerol pyrophosphatase family protein. (261 aa)
lolAOuter membrane lipocarrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (203 aa)
yiaHInner membrane protein YiaH; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. (330 aa)
yibLHypothetical protein. (118 aa)
CH53_1694Hypothetical protein. (239 aa)
CH53_1710Hypothetical protein. (112 aa)
CH53_1711Hypothetical protein; Dipeptidyl peptidase IV (DPP IV) N-terminal region family protein. (434 aa)
viaAVWA domain containing CoxE-like family protein. (488 aa)
ravAAAA domain family protein; Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone; Belongs to the RavA family. (502 aa)
bssSbssS family protein. (84 aa)
yihDProtein yihD. (89 aa)
CH53_1890Hypothetical protein. (201 aa)
zapBCell division protein ZapB; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (79 aa)
CH53_2023yhhN-like family protein. (208 aa)
CH53_2024Hypothetical protein. (106 aa)
CH53_2025Hypothetical protein. (127 aa)
CH53_2026Hypothetical protein. (90 aa)
yhhKAcetyltransferase domain protein; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion; Belongs to the PanZ/PanM family. (130 aa)
CH53_206Bacterial sensory transduction regulator family protein. (161 aa)
psiEProtein psiE. (135 aa)
pspGphageshock_pspG: phage shock protein G. (72 aa)
panFpanF: sodium/pantothenate symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (484 aa)
CH53_2192Hypothetical protein. (80 aa)
aaeXHypothetical protein. (67 aa)
yhcQEfflux transporter, RND family, MFP subunit; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (311 aa)
yhcP_2Aluminum activated malate transporter family protein; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell; Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. (654 aa)
yhcBHypothetical protein. (134 aa)
lpoAlppC lipofamily protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (659 aa)
CH53_2581Hypothetical protein. (246 aa)
zapACell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (109 aa)
CH53_2616ygfB_yecA: yecA family protein; Belongs to the UPF0149 family. (192 aa)
CH53_263yejG-like family protein. (115 aa)
ygdRHypothetical protein. (73 aa)
CH53_2716Hypothetical protein; Belongs to the UPF0325 family. (129 aa)
rofProtein rof. (86 aa)
yaePHypothetical protein. (66 aa)
tsaAtRNA_TsaA: tRNA-Thr(GGU) m(6)t(6)A37 methyltransferase TsaA. (235 aa)
rcsFPutative protein rcsF; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (135 aa)
frsAAlpha/beta hydrolase family protein; Belongs to the UPF0255 family. (415 aa)
crlSigma factor-binding protein crl; Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32; Belongs to the Crl family. (133 aa)
ycgRFlagellar brake protein YcgR; Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility. (249 aa)
CH53_2813Hypothetical protein. (89 aa)
pgpAPhosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (165 aa)
CH53_2858Hypothetical protein. (192 aa)
sgrR_2Bacterial extracellular solute-binding s, 5 Middle family protein. (567 aa)
hhaHemolysin expression-modulating protein. (67 aa)
tomBBiofilm formation regulator YbaJ family protein. (122 aa)
capBPutative cold-shock protein. (159 aa)
CH53_3126Hypothetical protein. (68 aa)
CH53_3150cyd_oper_ybgE: cyd operon protein YbgE. (97 aa)
ompC2Gram-negative porin family protein; Belongs to the Gram-negative porin family. (371 aa)
ompXOuter membrane protein X. (175 aa)
CH53_3304asmA family protein. (615 aa)
ompCOuter membrane protein C; Belongs to the Gram-negative porin family. (368 aa)
yeeXHypothetical protein; Belongs to the UPF0265 family. (105 aa)
yfaZyfaZ family protein. (180 aa)
uspA_1Universal stress family protein. (139 aa)
CH53_3619Hypothetical protein. (74 aa)
pgsACDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa)
ompDGram-negative porin family protein. (361 aa)
CH53_3759Hypothetical protein. (90 aa)
ycdXPHP domain protein; Belongs to the PHP family. (245 aa)
ycdYNitrate reductase delta subunit. (184 aa)
yceBHypothetical protein. (187 aa)
yecMProtein yecM. (186 aa)
mipAmltA-interacting protein. (256 aa)
hnsDNA-binding protein H-NS; Belongs to the histone-like protein H-NS family. (135 aa)
yciUHypothetical protein; Belongs to the UPF0263 family. (107 aa)
clsCardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (486 aa)
yfbUHypothetical protein; Belongs to the UPF0304 family. (164 aa)
yciCHypothetical protein. (255 aa)
mdoCAcyltransferase family protein; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. (387 aa)
yciNProtein yciN. (83 aa)
pgpBPAP2 superfamily protein. (255 aa)
bhsAMultiple stress resistance protein BhsA. (86 aa)
ydgAHypothetical protein. (508 aa)
tusDNA replication terminus site-binding protein; Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence; Belongs to the Tus family. (310 aa)
ynfDHypothetical protein. (81 aa)
ynfBHypothetical protein; Belongs to the UPF0482 family. (121 aa)
yhjH_2EAL domain protein. (230 aa)
ydgHProtein ydgH. (317 aa)
blaSETrypsin family protein; Belongs to the peptidase S1B family. (279 aa)
CH53_4043Hypothetical protein. (101 aa)
mliCMembrane-bound lysozyme-inhibitor of c-type lysozyme family protein. (105 aa)
lppMajor outer membrane lipoprotein Lpp. (78 aa)
yfeEyniB-like family protein. (184 aa)
ydjMInner membrane protein ydjM. (182 aa)
CH53_4348Hypothetical protein; Belongs to the UPF0181 family. (85 aa)
yobDHypothetical protein. (153 aa)
yiiSHypothetical protein. (98 aa)
CH53_4418Hypothetical protein; Belongs to the UPF0227 family. (180 aa)
lpoBHypothetical protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. (192 aa)
ycfLHypothetical protein. (129 aa)
CH53_4423HIT domain protein. (117 aa)
yfeYHypothetical protein. (202 aa)
CH53_567Hypothetical protein. (65 aa)
speGSpermidine N(1)-acetyltransferase. (181 aa)
CH53_653PRD domain protein. (427 aa)
CH53_672Haloacid dehalogenase-like hydrolase family protein. (234 aa)
CH53_744Hypothetical protein. (111 aa)
yafDendonuclease/Exonuclease/phosphatase family protein. (260 aa)
CH53_804Hypothetical protein. (255 aa)
ywaDPeptidase M20/M25/M40 family protein. (351 aa)
CH53_985Bacterial chaperone lipo family protein. (115 aa)
CH53_989Hypothetical protein; Belongs to the UPF0231 family. (120 aa)
ampEProtein AmpE. (284 aa)
Your Current Organism:
Yersinia intermedia
NCBI taxonomy Id: 631
Other names: ATCC 29909, CCUG 11292, CIP 80.28, DSM 18517, JCM 7579, NCTC 11469, Y. intermedia, strain 3953, strain Bottone 48, strain Chester 48
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