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metI_3 metI_3 cusB_2 cusB_2 folK folK fhuB fhuB clcA clcA macA_1 macA_1 proX proX proW proW proV proV mdtE mdtE cysT cysT cysW cysW cysA cysA kpsT kpsT macB_4 macB_4 macA_3 macA_3 sfuC sfuC yesO yesO ugpC_2 ugpC_2 ycjO ycjO mntB_4 mntB_4 mntB_3 mntB_3 ecfA1 ecfA1 btuC btuC btuD btuD qacE qacE clcB clcB znuC znuC znuB znuB nuoJ nuoJ nuoL nuoL metI metI nuoM nuoM CH53_3706 CH53_3706 tpd tpd efeU_1 efeU_1 efeO efeO efeU_2 efeU_2 fbpC fbpC cbiO cbiO cbiQ cbiQ cbiN cbiN cbiM cbiM proV-2 proV-2 opuBC opuBC phnE-2 phnE-2 phnE phnE modF modF kdpA kdpA kdpB kdpB kdpC kdpC metN metN fhuC_2 fhuC_2 mntB_1 mntB_1 acrA acrA tolC_2 tolC_2 CH53_3023 CH53_3023 ttgA ttgA lptG lptG lptF lptF ywrO ywrO kefB kefB ywrO_2 ywrO_2 cydD cydD cydC cydC metN2 metN2 metI_2 metI_2 macB_5 macB_5 macA_5 macA_5 potH potH potG potG mdxE mdxE ugpA ugpA ugpE ugpE ugpC ugpC malG malG malF malF malE malE malK malK lptB lptB tolC_1 tolC_1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
metI_3Binding--dependent transport system inner membrane component family protein. (223 aa)
cusB_2RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (513 aa)
folKfolK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. (159 aa)
fhuBIron(3+)-hydroxamate import system permease protein fhuB; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (665 aa)
clcAH(+)/Cl(-) exchange transporter ClcA. (478 aa)
macA_1RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (391 aa)
proXSubstrate binding domain of ABC-type glycine betaine transport system family protein. (334 aa)
proWBinding--dependent transport system inner membrane component family protein. (393 aa)
proVproV: glycine betaine/L-proline transport ATP binding subunit. (399 aa)
mdtERND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (437 aa)
cysTSulfate ABC transporter, permease protein CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa)
cysWpermease_CysW: sulfate ABC transporter, permease protein CysW. (291 aa)
cysASulfate ABC transporter, ATP-binding family protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (363 aa)
kpsTABC transporter family protein. (221 aa)
macB_4ABC transporter family protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (660 aa)
macA_3RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (402 aa)
sfuCABC transporter family protein; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (349 aa)
yesOBacterial extracellular solute-binding family protein. (429 aa)
ugpC_2ABC transporter family protein; Belongs to the ABC transporter superfamily. (375 aa)
ycjOBinding--dependent transport system inner membrane component family protein. (296 aa)
mntB_4ABC 3 transport family protein. (297 aa)
mntB_3ABC 3 transport family protein. (294 aa)
ecfA1ABC transporter family protein. (296 aa)
btuCfecCD transport family protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. (335 aa)
btuDABC transporter family protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. (252 aa)
qacESmall Multidrug Resistance family protein. (110 aa)
clcBVoltage gated chloride channel family protein; Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response; Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily. (415 aa)
znuCABC transporter family protein; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (252 aa)
znuBABC 3 transport family protein. (261 aa)
nuoJNADH-quinone oxidoreductase subunit J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (181 aa)
nuoLNDH_I_L: proton-translocating NADH-quinone oxidoreductase, chain L family protein. (614 aa)
metID-methionine transport system permease protein metI. (217 aa)
nuoMNADH-quinone oxidoreductase subunit M. (507 aa)
CH53_3706YHS domain protein. (467 aa)
tpdFe2+ transport family protein. (175 aa)
efeU_1Iron permease FTR1 family protein. (644 aa)
efeOImelysin family protein. (375 aa)
efeU_2Iron permease FTR1 family protein. (282 aa)
fbpCABC transporter family protein; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (370 aa)
cbiOCobalt ABC transporter, ATP-binding family protein; Part of an ABC transporter complex. Responsible for energy coupling to the transport system. (271 aa)
cbiQcbiQ_TIGR: cobalt ABC transporter, permease protein CbiQ. (225 aa)
cbiNCobalt transport family protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (93 aa)
cbiMCobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (245 aa)
proV-2ABC transporter family protein. (312 aa)
opuBCSubstrate binding domain of ABC-type glycine betaine transport system family protein. (310 aa)
phnE-2phnE: phosphonate ABC transporter, permease protein PhnE. (301 aa)
phnEphnE: phosphonate ABC transporter, permease protein PhnE. (287 aa)
modFABC transporter family protein. (491 aa)
kdpAK+-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (562 aa)
kdpBK+-transporting ATPase, B subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (688 aa)
kdpCK+-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (200 aa)
metND-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
fhuC_2ABC transporter family protein. (245 aa)
mntB_1ABC 3 transport family protein. (285 aa)
acrAAcriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (395 aa)
tolC_2type_I_sec_TolC: type I secretion outer membrane, TolC family protein. (447 aa)
CH53_3023RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (368 aa)
ttgARND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (360 aa)
lptGlptG_lptG: LPS export ABC transporter permease LptG. (356 aa)
lptFlptF_YjgP: LPS export ABC transporter permease LptF. (364 aa)
ywrOGeneral stress protein 14. (174 aa)
kefBTransporter, monovalent cation:proton antiporter-2 family protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (602 aa)
ywrO_2NADPH-dependent FMN reductase family protein; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB. (183 aa)
cydDcydD: thiol reductant ABC exporter, CydD subunit. (588 aa)
cydCcydC: thiol reductant ABC exporter, CydC subunit. (574 aa)
metN2ABC transporter family protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (338 aa)
metI_2Binding--dependent transport system inner membrane component family protein. (219 aa)
macB_5ABC transporter family protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (649 aa)
macA_5RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (370 aa)
potHPutrescine transport system permease protein PotH. (321 aa)
potGPolyamine ABC transporter, ATP-binding family protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (377 aa)
mdxEBacterial extracellular solute-binding family protein. (439 aa)
ugpABinding--dependent transport system inner membrane component family protein. (295 aa)
ugpEBinding--dependent transport system inner membrane component family protein; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. (281 aa)
ugpCSn-glycerol-3-phosphate import ATP-binding protein UgpC; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family. (357 aa)
malGBinding--dependent transport system inner membrane component family protein. (296 aa)
malFBinding--dependent transport system inner membrane component family protein. (525 aa)
malEMaltose-binding periplasmic protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. Belongs to the bacterial solute-binding protein 1 family. (403 aa)
malKMaltose/maltodextrin import ATP-binding protein MalK; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (371 aa)
lptBLPS_export_lptB: LPS export ABC transporter ATP-binding protein. (241 aa)
tolC_1type_I_sec_TolC: type I secretion outer membrane, TolC family protein. (493 aa)
Your Current Organism:
Yersinia intermedia
NCBI taxonomy Id: 631
Other names: ATCC 29909, CCUG 11292, CIP 80.28, DSM 18517, JCM 7579, NCTC 11469, Y. intermedia, strain 3953, strain Bottone 48, strain Chester 48
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