STRINGSTRING
murA murA ADQ39836.1 ADQ39836.1 murB murB speH speH ADQ40062.1 ADQ40062.1 ADQ40063.1 ADQ40063.1 mrnC mrnC ADQ40065.1 ADQ40065.1 ADQ40070.1 ADQ40070.1 ADQ40071.1 ADQ40071.1 ADQ40072.1 ADQ40072.1 ADQ40073.1 ADQ40073.1 ddl ddl murI murI ADQ40076.1 ADQ40076.1 ADQ40078.1 ADQ40078.1 ADQ40079.1 ADQ40079.1 murA-2 murA-2 glmU glmU ADQ40281.1 ADQ40281.1 ADQ40378.1 ADQ40378.1 ADQ40745.1 ADQ40745.1 ADQ40771.1 ADQ40771.1 ADQ40779.1 ADQ40779.1 ADQ40781.1 ADQ40781.1 ADQ40782.1 ADQ40782.1 ADQ40783.1 ADQ40783.1 ADQ40784.1 ADQ40784.1 ADQ40785.1 ADQ40785.1 ADQ40786.1 ADQ40786.1 ADQ40787.1 ADQ40787.1 ADQ40788.1 ADQ40788.1 ADQ40789.1 ADQ40789.1 ADQ40790.1 ADQ40790.1 ADQ40791.1 ADQ40791.1 ADQ40792.1 ADQ40792.1 ADQ40793.1 ADQ40793.1 ADQ40794.1 ADQ40794.1 ADQ40795.1 ADQ40795.1 ADQ40796.1 ADQ40796.1 minC minC ADQ40798.1 ADQ40798.1 minE minE rodA rodA mgsA mgsA ADQ40802.1 ADQ40802.1 ADQ40803.1 ADQ40803.1 ADQ40804.1 ADQ40804.1 ADQ40805.1 ADQ40805.1 speE speE ADQ40807.1 ADQ40807.1 ADQ41082.1 ADQ41082.1 ADQ41083.1 ADQ41083.1 ADQ41084.1 ADQ41084.1 ADQ41213.1 ADQ41213.1 ADQ41257.1 ADQ41257.1 ADQ41258.1 ADQ41258.1 ADQ41270.1 ADQ41270.1 ftsZ ftsZ ADQ41409.1 ADQ41409.1 ADQ41410.1 ADQ41410.1 ADQ41411.1 ADQ41411.1 murA-3 murA-3 murG murG ADQ41414.1 ADQ41414.1 murD murD mraY mraY murF murF murE murE ADQ41419.1 ADQ41419.1 ADQ41420.1 ADQ41420.1 rsmH rsmH mraZ mraZ ADQ41423.1 ADQ41423.1 lgt lgt ADQ41425.1 ADQ41425.1 ADQ41426.1 ADQ41426.1 ADQ41427.1 ADQ41427.1 ADQ41428.1 ADQ41428.1 ADQ41519.1 ADQ41519.1 murC murC glmS glmS glmM glmM ADQ41796.1 ADQ41796.1 ADQ41797.1 ADQ41797.1 ADQ41950.1 ADQ41950.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (414 aa)
ADQ39836.1PFAM: LmbE family protein; KEGG: ate:Athe_0312 LmbE family protein. (487 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (314 aa)
speHS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (124 aa)
ADQ40062.1PFAM: MgtC/SapB transporter; KEGG: ate:Athe_2051 MgtC/SapB transporter. (216 aa)
ADQ40063.1PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: ate:Athe_2050 Orn/Lys/Arg decarboxylase major region. (493 aa)
mrnCRibonuclease III; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (146 aa)
ADQ40065.1PFAM: protein of unknown function DUF1646; KEGG: ate:Athe_2048 protein of unknown function DUF1646. (341 aa)
ADQ40070.1KEGG: ate:Athe_2043 RNA methyltransferase, TrmH family, group 3; TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (253 aa)
ADQ40071.1PFAM: protein of unknown function DUF901; KEGG: ate:Athe_2042 protein of unknown function DUF901. (168 aa)
ADQ40072.1RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: ate:Athe_2041 RNA polymerase factor sigma-70; TIGRFAM: RNA polymerase sigma-H factor; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (211 aa)
ADQ40073.1PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: ate:Athe_2040 phosphomannomutase. (467 aa)
ddlD-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (364 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (267 aa)
ADQ40076.1PFAM: Domain of unknown function DUF1934; KEGG: ate:Athe_2037 hypothetical protein. (146 aa)
ADQ40078.1KEGG: ate:Athe_2035 coenzyme F390 synthetase-like protein. (471 aa)
ADQ40079.1PFAM: ferredoxin-dependent glutamate synthase; KEGG: ate:Athe_2034 ferredoxin-dependent glutamate synthase. (529 aa)
murA-2UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (465 aa)
ADQ40281.1TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; KEGG: ate:Athe_1946 UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase. (385 aa)
ADQ40378.1TIGRFAM: nucleotide sugar dehydrogenase; KEGG: ate:Athe_1818 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (426 aa)
ADQ40745.1PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: ate:Athe_1255 serine-type D-Ala-D-Ala carboxypeptidase. (451 aa)
ADQ40771.1KEGG: ate:Athe_1280 serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein. (387 aa)
ADQ40779.1KEGG: ate:Athe_1287 hypothetical protein. (183 aa)
ADQ40781.1TIGRFAM: hemolysin A; PFAM: RNA-binding S4 domain protein; ribosomal RNA methyltransferase RrmJ/FtsJ; KEGG: ate:Athe_1289 hemolysin A; SMART: RNA-binding S4 domain protein. (269 aa)
ADQ40782.1KEGG: ate:Athe_1290 hypothetical protein. (117 aa)
ADQ40783.1PFAM: ATP-binding region ATPase domain protein; KEGG: ate:Athe_1291 putative anti-sigma regulatory factor, serine/threonine protein kinase. (139 aa)
ADQ40784.1PFAM: Fe-S cluster domain protein; KEGG: ate:Athe_1292 Fe-S cluster domain protein. (443 aa)
ADQ40785.1KEGG: ate:Athe_1293 hypothetical protein. (116 aa)
ADQ40786.1KEGG: ate:Athe_1294 PHP domain protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein. (233 aa)
ADQ40787.1PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; KEGG: ate:Athe_1295 NADH dehydrogenase (ubiquinone) 24 kDa subunit. (160 aa)
ADQ40788.1KEGG: ate:Athe_1296 histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein. (185 aa)
ADQ40789.1KEGG: ate:Athe_1297 hypothetical protein. (129 aa)
ADQ40790.1KEGG: ate:Athe_1298 NADH dehydrogenase (quinone); PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding. (598 aa)
ADQ40791.1KEGG: ate:Athe_1299 hydrogenase, Fe-only; TIGRFAM: hydrogenase, Fe-only; PFAM: hydrogenase large subunit domain protein; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; iron hydrogenase small subunit. (579 aa)
ADQ40792.1Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (202 aa)
ADQ40793.1KEGG: ate:Athe_1301 rod shape-determining protein MreB; TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl. (343 aa)
ADQ40794.1Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. (283 aa)
ADQ40795.1KEGG: ate:Athe_1303 hypothetical protein. (174 aa)
ADQ40796.1KEGG: ate:Athe_1304 penicillin-binding protein 2; TIGRFAM: penicillin-binding protein 2; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. (700 aa)
minCSeptum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (215 aa)
ADQ40798.1TIGRFAM: septum site-determining protein MinD; KEGG: ate:Athe_1306 septum site-determining protein MinD. (266 aa)
minECell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (100 aa)
rodARod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (369 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (141 aa)
ADQ40802.1PFAM: Thiamin pyrophosphokinase catalytic domain-containing protein; KEGG: ate:Athe_1310 thiamin pyrophosphokinase catalytic region. (371 aa)
ADQ40803.1KEGG: ate:Athe_1311 hypothetical protein. (314 aa)
ADQ40804.1PFAM: glycosyl transferase family 2; KEGG: ate:Athe_1312 glycosyl transferase family 2. (222 aa)
ADQ40805.1KEGG: ate:Athe_1313 hypothetical protein. (282 aa)
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (278 aa)
ADQ40807.1Agmatinase; KEGG: ate:Athe_1315 agmatinase; TIGRFAM: agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (285 aa)
ADQ41082.1KEGG: ate:Athe_1559 serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein. (386 aa)
ADQ41083.1KEGG: ate:Athe_1560 spore cortex-lytic enzyme; TIGRFAM: spore cortex-lytic enzyme; PFAM: cell wall hydrolase SleB; Peptidoglycan-binding domain 1 protein. (225 aa)
ADQ41084.1KEGG: ate:Athe_1561 hypothetical protein. (101 aa)
ADQ41213.1PFAM: Polynucleotide adenylyltransferase region; KEGG: ate:Athe_1710 tRNA adenylyltransferase. (394 aa)
ADQ41257.1PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: ate:Athe_1752 phosphoglucomutase. (463 aa)
ADQ41258.1PFAM: major facilitator superfamily MFS_1; KEGG: csc:Csac_2298 major facilitator transporter. (394 aa)
ADQ41270.1PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Mur ligase middle domain protein; KEGG: ate:Athe_0527 Mur ligase middle domain protein. (741 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (360 aa)
ADQ41409.1PFAM: protein of unknown function DUF1290; KEGG: ate:Athe_0782 hypothetical protein. (120 aa)
ADQ41410.1PFAM: protein of unknown function DUF881; KEGG: ate:Athe_0781 protein of unknown function DUF881. (247 aa)
ADQ41411.1Polypeptide-transport-associated domain protein FtsQ-type; Essential cell division protein. (244 aa)
murA-3UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (442 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (369 aa)
ADQ41414.1KEGG: ate:Athe_0777 cell division protein FtsW; TIGRFAM: cell division protein FtsW; PFAM: cell cycle protein; Belongs to the SEDS family. (361 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (458 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (320 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (448 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa)
ADQ41419.1SMART: PASTA domain containing protein; TIGRFAM: stage V sporulation protein D; KEGG: ate:Athe_0772 stage V sporulation protein D; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PASTA domain containing protein. (719 aa)
ADQ41420.1PFAM: Septum formation initiator; KEGG: ate:Athe_0771 septum formation initiator. (166 aa)
rsmHS-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (307 aa)
mraZMraZ protein; KEGG: ate:Athe_0769 cell division protein MraZ; TIGRFAM: MraZ protein; PFAM: MraZ domain; Belongs to the MraZ family. (143 aa)
ADQ41423.1KEGG: ate:Athe_0768 hypothetical protein. (59 aa)
lgtProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (267 aa)
ADQ41425.1PFAM: peptidase M16 domain protein; KEGG: ate:Athe_0766 peptidase M16 domain protein. (433 aa)
ADQ41426.1PFAM: peptidase M16 domain protein; KEGG: ate:Athe_0765 peptidase M16 domain protein. (424 aa)
ADQ41427.1KEGG: csc:Csac_0912 HI0074 family nucleotidyltransferase substrate binding protein; TIGRFAM: nucleotidyltransferase substrate binding protein, HI0074 family; PFAM: Nucleotidyltransferase substrate binding protein HI0074. (133 aa)
ADQ41428.1PFAM: DNA polymerase beta domain protein region; KEGG: ate:Athe_0763 DNA polymerase beta domain protein region. (109 aa)
ADQ41519.1KEGG: ate:Athe_0096 N-acetylglucosamine-6-phosphate deacetylase; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; PFAM: amidohydrolase. (380 aa)
murCUDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (455 aa)
glmSGlucosamine/fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (611 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (449 aa)
ADQ41796.1KEGG: csc:Csac_0604 hypothetical protein. (432 aa)
ADQ41797.1KEGG: csc:Csac_0603 ATPase; PFAM: ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase. (783 aa)
ADQ41950.1KEGG: ate:Athe_2648 penicillin-binding protein, 1A family; TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase. (817 aa)
Your Current Organism:
Caldicellulosiruptor kristjanssonii
NCBI taxonomy Id: 632335
Other names: C. kristjanssonii I77R1B, Caldicellulosiruptor kristjanssonii DSM 12137, Caldicellulosiruptor kristjanssonii I77R1B, Caldicellulosiruptor kristjanssonii str. I77R1B, Caldicellulosiruptor kristjanssonii strain I77R1B
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