STRINGSTRING
Tagg_0106 Tagg_0106 Tagg_0024 Tagg_0024 Tagg_0008 Tagg_0008 Tagg_1373 Tagg_1373 Tagg_1369 Tagg_1369 Tagg_1237 Tagg_1237 Tagg_1203 Tagg_1203 Tagg_1183 Tagg_1183 Tagg_1157 Tagg_1157 tmk tmk Tagg_1147 Tagg_1147 Tagg_1081 Tagg_1081 nadK nadK Tagg_0970 Tagg_0970 Tagg_0923 Tagg_0923 cmk cmk Tagg_0777 Tagg_0777 thiM thiM Tagg_0735 Tagg_0735 adk adk Tagg_0682 Tagg_0682 Tagg_0655 Tagg_0655 Tagg_0644 Tagg_0644 mptE mptE Tagg_0571 Tagg_0571 Tagg_0553 Tagg_0553 Tagg_0532 Tagg_0532 Tagg_0486 Tagg_0486 thiL thiL Tagg_0374 Tagg_0374 mvk mvk Tagg_0307 Tagg_0307 pgk pgk Tagg_0192 Tagg_0192 Tagg_0139 Tagg_0139 Tagg_0132 Tagg_0132
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tagg_0106Protein of unknown function DUF120; COGs: COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon; InterPro IPR002834; KEGG: eba:ebA3131 hypothetical protein; PFAM: protein of unknown function DUF120; SPTR: B8D5C1 Riboflavin kinase; PFAM: Domain of unknown function DUF120. (143 aa)
Tagg_0024Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (227 aa)
Tagg_0008Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (199 aa)
Tagg_1373Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (161 aa)
Tagg_1369COGs: COG3642 Mn2+-dependent serine/threonine protein kinase; InterPro IPR018934:IPR002575:IPR002290:IPR000719; KEGG: hypothetical protein; K08851 TP53 regulating kinase; PFAM: RIO-like kinase; aminoglycoside phosphotransferase; SMART: serine/threonine protein kinase; SPTR: B8D6D5 Mn2+-dependent serine/threonine protein kinase; PFAM: RIO1 family. (225 aa)
Tagg_1237COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015794:IPR001697; KEGG: nis:NIS_1773 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: A3DMY9 Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (467 aa)
Tagg_1203COGs: COG0630 Type IV secretory pathway VirB11 protein involved in flagella biosynthesis; InterPro IPR001482; KEGG: dac:Daci_2070 type II secretion system protein E; PFAM: type II secretion system protein E; SPTR: Q9YAP7 Archaeal flagellar protein I homolog; PFAM: Type II/IV secretion system protein. (566 aa)
Tagg_1183ATP-NAD/AcoX kinase; COGs: COG3199 conserved hypothetical protein; InterPro IPR002504; KEGG: cja:CJA_2375 NAD(+)/NADH kinase; PFAM: ATP-NAD/AcoX kinase; SPTR: B8D5H1 ATP-NAD/AcoX kinase; PFAM: ATP-NAD kinase. (377 aa)
Tagg_1157COGs: COG1341 GTPase or GTP-binding protein; KEGG: Nol9; nucleolar protein 9; SPTR: B8D2S7 Putative GTPase or GTP-binding protein; PFAM: Molybdopterin guanine dinucleotide synthesis protein B. (416 aa)
tmkCOGs: COG0125 Thymidylate kinase; InterPro IPR000062:IPR018095:IPR018094; KEGG: xfn:XfasM23_1654 dTMP kinase; PFAM: thymidylate kinase; PRIAM: dTMP kinase; SPTR: B8D357 Thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase. (203 aa)
Tagg_1147ParB domain protein nuclease; InterPro IPR003115; KEGG: plu:plu1410 hypothetical protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; SPTR: A3DM02 ParB domain protein nuclease; PFAM: ParB-like nuclease domain. (286 aa)
Tagg_1081COGs: COG1608 kinase; InterPro IPR001048; KEGG: hypothetical protein; PFAM: aspartate/glutamate/uridylate kinase; SPTR: B8D6N7 Aspartate/glutamate/uridylate kinase; PFAM: Amino acid kinase family. (261 aa)
nadKATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (272 aa)
Tagg_0970RIO-like kinase; COGs: COG1718 Serine/threonine protein kinase involved in cell cycle control; InterPro IPR018934:IPR000687:IPR000719:IPR018935; KEGG: RIO1 family protein (EC:2.7.11.1); K07178 RIO kinase 1; PFAM: RIO-like kinase; SMART: protein of unknown function RIO1; SPTR: B8D5N2 Putative kinase; PFAM: RIO1 family. (270 aa)
Tagg_0923Phage shock protein C, PspC; COGs: COG1983 Putative stress-responsive transcriptional regulator protein; InterPro IPR007168; KEGG: cbc:CbuK_0644 stress-responsive transcriptional regulator; PFAM: PspC domain protein; SPTR: O58807 Putative uncharacterized protein PH1080; PFAM: PspC domain. (159 aa)
cmkCOGs: COG1102 Cytidylate kinase; InterPro IPR011892; KEGG: similar to UMP-CMP kinase (Cytidylate kinase) (Deoxycytidylate kinase) (Cytidine monophosphate kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Uridine monophosphate kinase); PRIAM: Cytidylate kinase; SPTR: B8D5U4 Cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Adenylate kinase; TIGRFAM: cytidylate kinase, putative. (180 aa)
Tagg_0777Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR013749:IPR004399; KEGG: sfu:Sfum_1692 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: B8D4K9 Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase. (290 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (274 aa)
Tagg_0735PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR002139:IPR011611; KEGG: hiq:CGSHiGG_05785 ribokinase; PFAM: PfkB domain protein; SPTR: A3DLR5 PfkB domain protein; PFAM: pfkB family carbohydrate kinase. (315 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (223 aa)
Tagg_0682Hypothetical protein; KEGG: mxa:MXAN_0768 PfkB family kinase; SPTR: A3DP83 Putative uncharacterized protein; PFAM: pfkB family carbohydrate kinase. (284 aa)
Tagg_0655COGs: COG1829 kinase (sugar kinase superfamily); SPTR: B8D3I2 Kinase (Sugar kinase superfamily)-like protein. (279 aa)
Tagg_0644Aminoglycoside phosphotransferase; COGs: COG3281 Uncharacterized protein probably involved in trehalose biosynthesis; InterPro IPR002575; KEGG: gem:GM21_0117 trehalose synthase; PFAM: aminoglycoside phosphotransferase; SPTR: B8D3J4 Alpha amylase. (478 aa)
mptEProtein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (246 aa)
Tagg_0571Hypothetical protein. (224 aa)
Tagg_0553COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR002139:IPR011611:IPR002173; KEGG: gbm:Gbem_2483 PfkB domain protein; PFAM: PfkB domain protein; SPTR: B8D4B0 ATP-dependent 6-phosphofructokinase; PFAM: pfkB family carbohydrate kinase. (306 aa)
Tagg_0532Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (830 aa)
Tagg_0486ROK family protein; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600:IPR006025; KEGG: rlt:Rleg2_5489 ROK family protein; PFAM: ROK family protein; SPTR: B8D441 Glucokinase (ROK family protein); PFAM: ROK family. (322 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa)
Tagg_0374COGs: COG0630 Type IV secretory pathway VirB11 protein involved in flagella biosynthesis; InterPro IPR001482; KEGG: sfu:Sfum_1498 type II secretion system protein E; PFAM: type II secretion system protein E; SPTR: B8D2U6 Type II secretion system protein E; PFAM: Type II/IV secretion system protein. (559 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (307 aa)
Tagg_0307COGs: COG0549 Carbamate kinase; InterPro IPR003964:IPR001048:IPR000623; KEGG: sat:SYN_01213 carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; SPTR: B8D366 Carbamate kinase-like carbamoyl phosphate synthetase; TIGRFAM: carbamate kinase; PFAM: Amino acid kinase family; TIGRFAM: carbamate kinase. (323 aa)
pgkCOGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576:IPR015911; KEGG: phosphoglycerate kinase; K00927 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: B8D2W5 Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (411 aa)
Tagg_0192COGs: COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain; InterProIPR015285:IPR018934:IPR000687:IPR008266:IPR 000719; KEGG: similar to S. cerevisiae YNL207W; K07179 RIO kinase 2; PFAM: RIO-like kinase; RIO2 kinase, winged helix domain protein; SMART: protein of unknown function RIO1; SPTR: A3DP27 Putative uncharacterized protein; PFAM: RIO1 family; Rio2, N-terminal. (292 aa)
Tagg_0139Ribose-phosphate pyrophosphokinase; COGs: COG0462 Phosphoribosylpyrophosphate synthetase; InterPro IPR000836:IPR002375:IPR006034:IPR005946; KEGG: wsu:WS1635 ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; PRIAM: Ribose-phosphate diphosphokinase; SPTR: A3DNX0 Ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (304 aa)
Tagg_0132COGs: COG2112 Ser/Thr protein kinase; SPTR: B8D3G5 Ser/Thr protein kinase-like protein. (253 aa)
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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